Allergic contact dermatitis from anthrarobin.

Bilateral indolent epidermotropic CD8-positive lymphoid proliferations of the ear

Klinik und Therapie der fr�hen lepromat�sen Lepra an einem Fallbeispiel

Taking into account the increase in worldwide human migration, leprosy is of growing importance in the differential diagnosis of dermatological diseases encountered in Central Europe. We report on the case of a young man from Ghana who developed hypopigmented maculae and plaques on his trunk and proximal limbs. The diagnosis of lepromatous leprosy could be made in consideration of the histological pattern of infiltrating leucocytes and detection of numerous acid-fast mycobacteria on skin biopsy. The results of the physical examination as well as routine laboratory and immunological parameters were consistent with this form of leprosy. Due to glucose-6-phosphate-dehydrogenase deficiency, tre…

Establishment and Characterization of an Angiosarcoma-Derived Cell Line, AS-M

A novel human endothelial cell line, AS-M, has been established from a cutaneous angiosarcoma on the scalp. The cells expressing platelet endothelial cell adhesion molecule-1 (CD31) were isolated using magnetic beads and subsequently cultured for a year. To date, the cells have undergone more than 100 population doublings (PDs). The AS-M cells manifested endothelial characteristics, such as active uptake of acetylated low-density lipoprotein labeled with 1,1'-dioctadecyl 3,3,3',3'-tetramethylindocarbocyanine perchlorate (Dil-Ac-LDL), capacity to bind the Ulex europeaus agglutin-I (UEA-I), and expression of von Willebrand factor (vWF) and CD31. The single cell-derived clone, AS-M.5, showed a…

Pruritus und Gallens�uren. Bestimmung von Sulfalithocholylglycin und Cholylglycin in der Saugblasenfl�ssigkeit und im Serum

Ob die Gallensauren im Organismus ursachlich bei dem zumeist ausgepragten Juckreiz bei Patienten mit Cholestase eine Rolle spielen, ist bislang ungeklart. Nachdem eine Korrelation zwischen Serumspiegel und Juckreiz nicht gefunden werden konnte, wurde eine Anreicherung von Gallensauren in der Haut fur den hepatogenen Pruritus verantwortlich gemacht. Dies konnte jedoch in Hauthomogenisaten nicht nachgewiesen werden, wogegen sich Gallensauren in den Oberflachenlipiden der Haut vermehrt fanden. Deshalb wurden in den vorliegenden Untersuchungen die Gallensauren Cholylglycin und Sulfalithocholylglycin in der Flussigkeit experimentell erzeugter subepidermaler Blasen sowie im Serum bestimmt. In der…

Granuloma anulare disseminatum als seltene Nebenwirkung von Allopurinol

During long-term therapy of hyperuricaemia with allopurinol (300 mg/d) two patients developed generalized granuloma annulare. The diagnoses were confirmed by histology; concomitant diseases, especially diabetes mellitus, were not detectable. Following discontinuation of allopurinol therapy, cutaneous granulomas healed without relapse. Hyperuricaemia could be controlled by low-purine diet and medication avoiding allopurinol. The clinical history of our two patients suggested a causal connection between allopurinol therapy and generalized granuloma annulare. For this reason we rate the development of this disease in both cases as a rare but significant side effect of allopurinol. This should …

Development of oil cysts after subcutaneous injection of interferon-α and interleukin-2

Beidseitige indolente epidermotrope CD8-positive lymphoide Proliferation der Ohrhelix

30 Jahre Verlaufsbeobachtung eines kongenitalen Dermatofibrosarcoma protuberans

The Man Behind the Eponym: Hans Biberstein and Follicular Hyperplasia Overlying Dermatofibroma

Hans Biberstein first described the basaloid follicular hyperplasia overlying dermatofibromas in 1923 and published his extensive observations on the subject in 1931. Part of Josef Jadassohn's department in Breslau, he was forced to leave German by the National Socialist regime and spent the rest of his career in New York. After a hiatus of 30 years, the dermatopathologic literature once again began addressing his seminal finding but never gave him proper credit. We suggest Biberstein's sign as an appropriate term for basaloid follicular hyperplasia overlying a dermatofibroma and as a small tribute to a pioneer dermatopathologist.

Successful treatment of adult multisystemic Langerhans cell histiocytosis with psoralen-UV-A, prednisolone, mercaptopurine, and vinblastine.

Background Langerhans cell histiocytosis (LCH) is a rare disease with a peak incidence in childhood. There is limited experience with treatment options for adult patients having multisystemic LCH involvement. We report successful treatment of a 70-year-old woman with adult onset of LCH and multisystem disease (diabetes insipidus centralis, bone marrow infiltration, and lung and skin involvement). Observations A 70-year-old woman with erythematous plaques and papules of the submammary and inguinal skin attended our outpatient clinic and was diagnosed as having LCH. Organ involvement was found in the infundibulum of the pituitary gland, associated with diabetes insipidus centralis, bone marro…