Time-dependent alignment of molecules trapped in octahedral crystal fields.

The hindered rotational states of molecules confined in crystal fields of octahedral symmetry, and their time-dependent alignment obtained by pulsed nonresonant laser fields, are studied computationally. The control over the molecular axis direction is discussed based on the evolution of the rotational wave packet generated in the cubic crystal-field potential. The alignment degree obtained in a cooperative case, where the alignment field is applied in a favorable crystal-field direction, or in a competitive direction, where the crystal field has a saddle point, is presented. The investigation is divided into two time regimes where the pulse duration is either ultrashort, leading to nonadia…

Melanoma-Reactive Class I-Restricted Cytotoxic T Cell Clones Are Stimulated by Dendritic Cells Loaded with Synthetic Peptides, but Fail to Respond to Dendritic Cells Pulsed with Melanoma-Derived Heat Shock Proteins In Vitro

Abstract Immunization with heat shock proteins (hsp) isolated from cancer cells has been shown to induce a protective antitumor response. The mechanism of hsp-dependent cellular immunity has been attributed to a variety of immunological activities mediated by hsp. Hsp have been shown to bind antigenic peptides, trim the bound peptides by intrinsic enzymatic activity, improve endocytosis of the chaperoned peptides by APCs, and enhance the ability of APCs to stimulate peptide-specific T cells. We have investigated the potential capacity of hsp70 and gp96 to function as a mediator for Ag-specific CTL stimulation in an in vitro model for human melanoma. Repetitive stimulation of PBLs by autolog…

First experimental study of photon polarization in radiative B0s decays.

The polarization of photons produced in radiative $B^{0}_{s}$ decays is studied for the first time. The data are recorded by the LHCb experiment in $pp$ collisions corresponding to an integrated luminosity of 3fb$^{-1}$ at center-of-mass energies of $7$ and $8$TeV. A time-dependent analysis of the $B^{0}_{s} \to \phi \gamma$ decay rate is conducted to determine the parameter ${\mathcal{A}}^\Delta$, which is related to the ratio of right- over left-handed photon polarization amplitudes in $b \to s \gamma$ transitions. A value of ${\mathcal{A}}^\Delta=-0.98^{\,+0.46\,+0.23}_{\,-0.52\,-0.20}$ is measured. This result is consistent with the Standard Model prediction within two standard deviatio…

Measurement of CP asymmetries in two-body B(s)0 -meson decays to charged pions and kaons

The time-dependent CP asymmetries in B0→π+π− and B0s→K+K− decays are measured using a data sample of p p collisions corresponding to an integrated luminosity of 3.0  fb−1, collected with the LHCb detector at center-of-mass energies of 7 and 8 TeV. The same data sample is used to measure the time-integrated CP asymmetries in B0→K+π− and B0s→π+K− decays. The results are Cπ+π−=−0.34±0.06±0.01, Sπ+π−=−0.63±0.05±0.01, CK+K−=0.20±0.06±0.02, SK+K−=0.18±0.06±0.02, AΔΓK+K−=−0.79±0.07±0.10, AB0CP=−0.084±0.004±0.003, and AB0sCP=0.213±0.015±0.007, where the first uncertainties are statistical and the second systematic. Evidence for CP violation is found in the B0s→K+K− decay for the first time.

Coherence and control of molecular dynamics in rare gas matrices

Requirements of Exogenous Protein Antigens for Presentation to CD4+ T lymphocytes By MHC Class II-Positive APC

The antigen-specific activation of CD4-positive T helper cells depends on the recognition of a complex of MHC class II molecules and an antigen-derived peptide on the surface of antigen-presenting cells (APC). For most antigens generation of this MHC/peptide complex requires the uptake of the respective antigen by APC, followed by intracellular processing. The latter leads to suitable peptides of the antigen which are able to bind to MHC class ll-molecules. Subsequently the resulting complexes are transported to the cell surface. Evidence supporting this concept came mainly from the finding that agents such as chloroquine1, interfering with the function of endosomes and lysosomes, can block…

Observation of the rare B(s)(0) + decay from the combined analysis of CMS and LHCb data.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported licence.-- et al.

Amplitude analysis ofB+→J/ψϕK+decays

The first full amplitude analysis of B+→J/ψϕK+ with J/ψ→μ+μ−, ϕ→K+K− decays is performed with a data sample of 3 fb−1 of pp collision data collected at s√=7 and 8 TeV with the LHCb detector. The data cannot be described by a model that contains only excited kaon states decaying into ϕK+, and four J/ψϕ structures are observed, each with significance over 5 standard deviations. The quantum numbers of these structures are determined with significance of at least 4 standard deviations. The lightest is best described as a D±sD∗∓s cusp, but a resonant interpretation is also possible with mass consistent with, but width much larger than, previous measurements of the claimed X(4140) state. The mode…

Measurement of the W boson mass

The W boson mass is measured using proton-proton collision data at root s = 13 TeV corresponding to an integrated luminosity of 1.7fb(-1) recorded during 2016 by the LHCb experiment. With a simultaneous fit of the muon q/p(T) distribution of a sample of W ->mu y decays and the phi* distribution of a sample of Z -> mu mu decays the W boson mass is determined to be

Observation of Bc+→J/ψD(*)K(*) decays

A search for the decays B + c → J / ψ D ( * ) 0 K + and B + c → J / ψ D ( * ) + K * 0 is performed with data collected at the LHCb experiment corresponding to an integrated luminosity of 3     fb − 1 . The decays B + c → J / ψ D 0 K + and B + c → J / ψ D * 0 K + are observed for the first time, while first evidence is reported for the B + c → J / ψ D * + K * 0 and B + c → J / ψ D + K * 0 decays. The branching fractions of these decays are determined relative to the B + c → J / ψ π + decay. The B + c mass is measured, using the J / ψ D 0 K + final state, to be 6274.28 ± 1.40 ( stat ) ± 0.32 ( syst )     MeV / c 2 . This is the most precise single measurement of the B + c mass to date.