A combined treatment regimen for desquamative gingivitis in patients with oral lichen planus

Background:  Chronic desquamative gingivitis (DG) is a condition characterized by erythema, ulceration, and desquamation of the free and attached gingiva, usually expression of a district-systemic disease, such as oral lichen planus (OLP). Methods:  A combined protocol of oral hygiene and topic corticosteroid therapy was applied in 30 patients with DG associated with OLP. Plaque index (PI) and bleeding on probing (BoP) were evaluated at baseline and after 3 months. Results:  PI scoring was significantly lower after treatment in anterior, posterior, and all sites (P < 0.0001) as well as in vestibular and lingual ones (P < 0.0001 and P = 0.0001, respectively). BoP measures were found to be re…

Malattia parodontale:fattore di rischio per insorgenza delle cardiopatie.Protocollo di indagine e risultati preliminari di uno studio multicentrico

The effects of an amine fluoride/stannous fluoride and an essential oil mouthrinse on supragingival plaque regrowth

Effect of desquamative gingivitis on periodontal status: a pilot study

Objective:  Desquamative gingivitis (DG) represents the gingival manifestation associated with several mucocutaneous disorders and systemic conditions. Little is known of whether or not DG could influence the onset or progression of plaque-related periodontitis. In this study, the potential impact of DG on plaque-related attachment loss and pocket formation has been evaluated. Methods:  A cross-sectional evaluation of 12 patients with DG [eight oral lichen planus (OLP), four mucous membrane pemphigoid (MMP)], never treated for DG lesions or plaque-related periodontitis, was carried out. Probing depth (PD), clinical attachment loss (CAL), full-mouth plaque (FMPS), and bleeding (FMBS) scores …

Periodontal medicine: ruolo della proteina C reattiva (C-RP) nella possibile associazione tra malattia parodontale e malattia cardiovascolare. Risultati preliminari di uno studio multicentrico.

Efficacia di un collutorio contenente fluoruro amminico/fluoruro stannoso nel management della gengivite desquamativa: studio pilota

Obiettivi: L’utilizzo prolungato di un agente chimico antiplacca potrebbe essere utile nella gestione clinica dei pazienti affetti da lesioni gengivali desquamative (LGD), associate a patologie muco-cutanee autoimmuni. Scopo di questo studio pilota è stato quello di valutare l’efficacia di un collutorio contenente fluoruro amminico/fluoruro stannoso (ASF) (Meridol, GABA) in pazienti affetti da LGD e sottoposti a terapia parodontale di mantenimento (PST). Materiali e metodi: Sono stati selezionati ed inclusi nello studio 18 pazienti di razza caucasica (15:3, F:M) di età compresa tra 42 e 78 anni, aventi manifestazioni cliniche orali riconducibili a LGD. La diagnosi istopatologica effettuata …

Halitosis and HCV-related liver disease:true association

Carico precoce su overdenture, valutazione a cinque anni.

La malattia parodontale necrotizzante:un aggiornamento

.Sco po di qu es to lavo ro è qu ello di pr esentare un aggio rnam ento su lla malatti aparodo nta le ne cro ti zza nt e (NPD). Attr averso laba nca dat i ME DLINE /Pu bMed, sono stati selezi onati i lav ori orig inali pubblicati in lingua inglese sull ’arg omento da gennaio 2002 a dicembre 2007. Altre fonti sono state seleziona te da i riferimenti bibliografici citati nei lavori consultati. La NPD è caratterizzata sul piano clinico da necrosi e ulcera zione del margine gengivale e della papilla interdentale, associat e ad alitosi, dolore, sanguinamento gengi vale spontaneo, malessere generale e talvolta febbre. La malattia è particolarmente diffusa nei paesi in via di sviluppo, ma può inso…

Diagnostic pathways and clinical significance of desquamative gingivitis:a review

The term desquamative gingivitis (DG) refers to a clinical manifestation that can be caused by several disorders. Many of them are immunologically mediated; in addition to the oral cavity, they can affect extraoral mucocutaneous sites, e.g., larynx, conjunctiva, esophagus, nasal and genital mucosa, and the skin. The degree of oral, periodontal, and systemic involvement determines the overall morbidity and, sometimes, the mortality of these disorders. We comprehensively review disorders commonly associated with DG and highlight diagnostic pathways, guidelines for differential diagnosis, and oral, periodontal, and systemic implications. More rare conditions are reviewed as well. Mucous membra…

Istiocitosi a cellule di Langerhans. Report di un caso a localizzazione mandibolare. Ruolo dell'odontoiatra nella diagnosi e nel managment clinico.

The effects of an amine fluoride/stannous fluoride and an antimicrobial host protein mouthrinse on supragingival plaque regrowth.

BACKGROUND: Chlorhexidine (CHX)-containing mouthrinses are recommended as adjuncts to mechanical oral hygiene. The problem associated with side effects, however, has stimulated the search for alternative antiplaque agents. The aim of this study was to investigate the plaque inhibitory effects of two mouthrinses containing amine fluoride/stannous fluoride (ASF) and antimicrobial host proteins (lactoperoxidase, lysozyme and lactoferrin; LLL), respectively. METHODS: The study was an observer-masked, randomized 4x4 Latin square cross-over design balanced for carryover effects, involving 12 healthy volunteers in a 4-day plaque regrowth model. A 0.12% CHX mouthrinse and a saline solution served a…

Istiocitosi a cellule di Langherans.report di un caso a localizzazione mandibolare.ruolo dell'odontoiatra nella diagnosi e nel management clinico

Effect of hormone replacement therapy (HRT) on periodontal status of postmenopausal women.

Summary Background The risks/benefits balance of hormone replacement therapy (HRT) is controversial. The aim of this study was to assess the periodontal status of a postmenopausal women group receiving HRT and to determine the effects of HRT on clinical measures of periodontal disease. Material/Methods Ninety-one postmenopausal women, 52 taking HRT (HRT+) and 39 not taking HRT (HRT−), completed the study. Clinical parameters measured included visible supragingival plaque, probing pocket depth (PD) and clinical attachment level (CAL). Gingival status was recorded as gingival bleeding on probing (BOP). Previous oral contraceptive use and current and past smoking status were also assessed. Res…

Rationale and advantages of chemical and mechanical plaque control in no plaque-related gingivitis. A combined protocol.

Ortopantomografia nel sospetto diagnostico di osteoporosi

The effects of antimicrobial sprays and mouthrinses on supragingival plaque regrowth: a comparative study.

BACKGROUND: Due to the side effects of chlorhexidine digluconate (CHX) mouthrinsing, a spray has been proposed as an alternative method of CHX delivery to the oral cavity. The aim of this study was to investigate the plaque inhibitory effects of CHX, cetylpyridinium chloride (CPC), and triclosan (TRN) delivered by sprays and mouthrinses. METHODS: The study was an observer-masked, randomized cross-over design balanced for carryover effects, involving 15 healthy volunteers in a 4-day plaque regrowth model. Products being tested (0.2% CHX, 0.12% CHX, 0.05% CPC, and 0.03% TRN) were used both as sprays and mouthrinses. A saline solution served as a negative control. On day 1, subjects received p…

Periodontal disease and systemic diseases: interrelationships and interactions

The focal infection theory, which for almost half a century justified indiscriminate extraction of teeth to cure focal infections, since the end of the 1940s has become progressively a discarded concept. In parallel with the declining importance assigned to pulp and periapical infections in the pathogenesis of focal diseases, over the last decade there has been increasing interest in the possible relationship between periodontal infection and systemic diseases. Periodontal pathogens and their products, as well as inflammatory mediators produced in gingival tissue, might enter the bloodstream through ulcerated pocket epithelium, causing systemic effects (focal diseases). On the basis of this…

Gengivite cronica desquamativa: approccio multidisciplinare in pazienti con lichen planus orale. Risultati di un open clinical trial.

Malattia parodontale e malattia cardiovascolare: correlazione o semplice coincidenza? Revisione della letteratura

The present paper reviews relationship between chronic periodontitis and cardiovascular diseases. Original papers on this subject, published in English in the period between 2001 and the first semester 2006, were located in the MEDLINE/PubMed database. Additional studies were obtained by searching reference lists of previously published papers. Periodontal infection provides a chronic reservoir of inflammatory mediators and cytokines, lipopolysaccharide, which contribute to the formation of atheroma. Moreover, periodontal pathogens can penetrate the epithelial barrier of the periodontal tissues and reach the blood stream, carrying out a local atherogenic activity. Some studies indicated tha…

GENGIVITE DESQUAMATIVA.IGIENISTA DENTALE E PROTOCOLLO DI IGIENE ORALE DOMICILIARE AD HOC

Diagnostic Pathways and Clinical Significance of Desquamative Gingivitis

The term desquamative gingivitis (DG) refers to a clinical manifestation that can be caused by several disorders. Many of them are immunologically mediated; in addition to the oral cavity, they can affect extraoral mucocutaneous sites, e.g., larynx, conjunctiva, esophagus, nasal and genital mucosa, and the skin. The degree of oral, periodontal, and systemic involvement determines the overall morbidity and, sometimes, the mortality of these disorders. We comprehensively review disorders commonly associated with DG and highlight diagnostic pathways, guidelines for differential diagnosis, and oral, periodontal, and systemic implications. More rare conditions are reviewed as well. Mucous membra…

ALITOSI ed EPATOPATIE: vera associazione o luogo comune? Studio pilota

Bifocal manifestation of eosinophilic granuloma in a paediatric patient-A case report

Background: Eosinophilic granuloma (EG) is a clinical variant of the Langerhans cell histiocytosis (LCH) characterized by unifocal or multifocal bone lesions which predominantly affects children, adolescents, and young adults. Case Report: A case is reported of a 13-year-old Caucasian boy who presented unifocal EG in the mandible as the first clinic manifestation. Radiographic examination and skeletal scintigraphy revealed a further localization with an osteolytic lesion in the right femur. The therapeutic protocol used for the mandibular lesion included causal periodontal therapy, extraction of the compromised teeth, alveolar curettage, and intralesional injections of corticosteroids, in c…

Report di localizzazione mandibolare dell'istiocitosi a cellule di Langherans

Maxillary angiosarcoma: case report

Effetto sulla formazione della placca batterica di alcuni chewing gum sugar-free. Indagine comparativa in vivo.

The effects of sugar-free chewing gums on dental plaque regrowth: a comparative study

Abstract Sugar-free chewing gum has been claimed to be a useful means of reducing dental plaque accumulation. The incorporation of additives, such as enzymes, abrasives and divalent metal ions, into gum formulations might improve their antiplaque activity, particularly at the buccal and lingual surfaces of the teeth. Objectives The aim of this study was to investigate the plaque inhibitory effects of three sugar-free chewing gums each containing lactoperoxidase (LP), micro granules of silicon dioxide (SD), and zinc gluconate (ZG). Methods The study was an observer-masked, randomized cross-over design balanced for carryover effects, involving 12 healthy volunteers in a 4-day plaque regrowth …

La malattia parodontale come fattore di rischio per l'insorgenza delle cardiopatie associate ad aterosclerosi. Risultati preliminari

Altosi ed Epatopatie: vera associazione o luogo comune?Studio pilota

Dentistry and internal medicine: from the focal infection theory to the periodontal medicine concept

Abstract During past decades the relationship between dentistry and internal medicine and especially the concept of the so-called focal infection theory have long been a matter of debate. The pathogenesis of focal diseases has been classically attributed to dental pulp pathologies and periapical infections. Nonetheless, in recent years, their role is being dismissed while increasing interest is being devoted to the possible associations between periodontal infection and systemic diseases. In fact, periodontal pathogens and their products, as well as inflammatory mediators produced in periodontal tissues, might enter the bloodstream, causing systemic effects and/or contributing to systemic d…

Periodontal status in postmenopausal women receiving hormone replacement therapy (HRT)

Epidemiology of desquamative gingivitis: evaluation of 125 patients and review of the literature

Background  Desquamative gingivitis (DG) is a descriptive term used to indicate epithelial desquamation, erythema, erosions, and/or vesiculobullous lesions of the gingiva. DG is commonly associated with several mucocutaneous disorders and systemic conditions that may carry a poor prognosis and high morbidity; however, there are no clear data concerning the frequency of these disease associations. Methods  We investigated the epidemiologic features of DG in 125 patients and compared our findings with information from a literature review. Results  In our series, 88% of patients with DG had one of the following three disorders: oral lichen planus (OLP), mucous membrane pemphigoid (MMP), or pem…

Pathophysiology of age-related diseases

Abstract A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy on 7-8 April 2009. Three lectures from that Symposium by G. Campisi, L. Ginaldi and F. Licastro are here summarized. Ageing is a complex process which negatively impacts on the development of various bodily systems and its ability to function. A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Thus, a better understanding of the pathophysiology of age-related diseases is urgently required to improve our understanding of maintaining good health in the elderly and to program possible therapeutic intervention.

Efficacia di un protocollo terapeutico multidisciplinare per la gengivite cronica desquamativa.

Salute parodontale e terapia ormonale sostitutiva (HRT): indagine su un campione di donne in menopausa

Aging and Oral Health: Effects in Hard and Soft Tissues

Changing demographics, including an increase in life expectancy and the growing numbers of elderly has recently focused attention on the need for geriatric dental care. Ageing affects oral tissues in addition to other parts of the human body, and oral health (including oral mucosa, lips, teeth and associated structures, and their functional activity) is an integral component of general health; indeed, oral disease can cause pain, difficulty in speaking, mastication, swallowing, maintaining a balanced diet, not to mention aesthetical considerations and facial alterations leading to anxiety and depression. The World Health Organization recommends the adoption of certain strategies for improvi…

Osteoporosis, jawbones and periodontal disease

The association between osteoporosis and jawbones remains an argument of debate. Both osteoporosis and periodontal diseases are bone resorptive diseases; it has been hypothesized that osteoporosis could be a risk factor for the progression of periodontal disease and vice versa. Hypothetical models linking the two conditions exist: in particular, it is supposed that the osteoporosis-related bone mass density reduction may accelerate alveolar bone resorption caused by periodontitis, resulting in a facilitated periodontal bacteria invasion. Invading bacteria, in turn, may alter the normal homeostasis of bone tissue, increasing osteoclastic activity and reducing local and systemic bone density …

Langerhans's cell histiocytosis in old subjects: two rare case reports and review of the literature

Background: Langerhans cell histiocytosis (LCH) is a proliferative disease of histiocyte-like cells that generally affects children; LCH onset is rare in adults; immunohistochemistry is essential to obtain the correct diagnosis, and treatment protocols are controversial. Objective: To describe two new cases of adult onset oral LCH. Case reports: Case 1: a 71-year-old woman, complaining of diffuse oral pain, presented with erythematous mucosal lesions; the panoramic radiograph and CT scan showed multiple mandible radiolucent areas. Immunohistochemical assay for S-100, CD1a and langerin test was essential in reaching the correct diagnosis. Case 2: a 77-year-old female patient presented with a…

Management del paziente con gengivite desquamativa. Studio caso controllo

Carico precoce su overdenture: valutazione a due anni (case report).

Report di localizzazione mandibolare dell'istiocitosi a cellule di Langerhans

Efficacia di un protocollo terapeutico multidisciplinare per la gengivite desquamativa

Gengivite desquamativa: studio pilota sull'efficacia di un collutorio contenente fluoruro amminico/fluoruro stannoso

Efficacia clinica di un collutorio contenente fluoruro amminico/fluoruro stannoso (ASF) in pazienti con lesioni gengivali desquamative (LGD)

The association between periodontal disease and cardiovascolar disesea.A narrative review

Langerhans’s cell histiocytosis in old subjects: two rare case reports and review of the literature

doi: 10.1111/j.1741-2358.2012.00629.x Langerhans’s cell histiocytosis in old subjects: two rare case reports and review of the literature Background:  Langerhans cell histiocytosis (LCH) is a proliferative disease of histiocyte-like cells that generally affects children; LCH onset is rare in adults; immunohistochemistry is essential to obtain the correct diagnosis, and treatment protocols are controversial. Objective:  To describe two new cases of adult onset oral LCH. Case reports:  Case 1: a 71-year-old woman, complaining of diffuse oral pain, presented with erythematous mucosal lesions; the panoramic radiograph and CT scan showed multiple mandible radiolucent areas. Immunohistochemical a…

Effetto sulla formazione della placca batterica in vivo di collutori contenenti fluoruro amminico/fluoruro stannoso e oli essenziali