0000000000003652

AUTHOR

Serafina Lacerenza

showing 3 related works from this author

Exposure to Gastric Acid Inhibitors Increases the Risk of Infection in Preterm Very Low Birth Weight Infants but Concomitant Administration of Lactof…

2018

Objective: To investigate whether exposure to inhibitors of gastric acidity, such as H2 blockers or proton pump inhibitors, can independently increase the risk of infections in very low birth weight (VLBW) preterm infants in the neonatal intensive care unit. Study design: This is a secondary analysis of prospectively collected data from a multicenter, randomized controlled trial of bovine lactoferrin (BLF) supplementation (with or without the probiotic Lactobacillus rhamnosus GG) vs placebo in prevention of late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) in preterm infants. Inhibitors of gastric acidity were used at the recommended dosages/schedules based on the clinical judgmen…

ColonizationProton Pump InhibitorNeonatal intensive care unitAdministration OralHistamine H2 AntagonistProbioticGastroenterologyPediatricsH2 blocker0302 clinical medicineRisk FactorsInfant Very Low Birth Weight030212 general & internal medicineCandidaVLBW neonateLacticaseibacillus rhamnosusGestational agePerinatology and Child HealthHistamine H2 AntagonistsItalyNecrotizing enterocolitismedicine.symptomInfectionInfant PrematureHumanmedicine.medical_specialtyBirth weightGastric AcidSepsis03 medical and health sciencesEnterocolitis NecrotizingIntensive Care Units NeonatalSepsis030225 pediatricsInternal medicinemedicineH2 blockersHumansDietary Supplementbusiness.industryRisk FactorProbioticsInfant NewbornProton Pump Inhibitorsmedicine.diseaseLow birth weightLactoferrinConcomitantDietary SupplementsPediatrics Perinatology and Child HealthVLBW neonatesCandida; Colonization; H2 blockers; Infection; Lactoferrin; VLBW neonates; Pediatrics Perinatology and Child HealthGastric acidLactobacillus rhamnosubusinessNew Zealand
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Urinary (1)H-NMR and GC-MS metabolomics predicts early and late onset neonatal sepsis.

2014

The purpose of this article is to study one of the most significant causes of neonatal morbidity and mortality: neonatal sepsis. This pathology is due to a bacterial or fungal infection acquired during the perinatal period. Neonatal sepsis has been categorized into two groups: early onset if it occurs within 3-6 days and late onset after 4-7 days. Due to the not-specific clinical signs, along with the inaccuracy of available biomarkers, the diagnosis is still a major challenge. In this regard, the use of a combined approach based on both nuclear magnetic resonance (H-1-NMR) and gas-chromatography-mass spectrometry (GC-MS) techniques, coupled with a multivariate statistical analysis, may hel…

Malemedicine.medical_specialtyPathologyMagnetic Resonance SpectroscopySepsiUrinary systemLate onsetMetabolomicDiseaseMass SpectrometrySepsisSettore MED/38 - Pediatria Generale E SpecialisticaInternal medicineSepsismedicineMetabolomeHumansNeonatal sepsisbusiness.industryCase-control studyInfant NewbornObstetrics and Gynecologymedicine.diseaseNewbornPrognosisCase-Control StudiesPediatrics Perinatology and Child HealthMetabolomePopulation studyFemalebusinessNeonatal infectionBiomarkersEarly human development
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Urinary metabolomics of bronchopulmonary dysplasia (BPD): preliminary data at birth suggest it is a congenital disease

2014

Abstract Objective: Bronchopulmonary dysplasia (BPD) or chronic lung disease is one of the principal causes of mortality and morbidity in preterm infants. Early identification of infants at the greater risk of developing BPD may allow a targeted approach for reducing disease severity and complications. The trigger cause of the disease comprehends the impairment of the alveolar development and the increased angiogenesis. Nevertheless, the molecular pathways characterizing the disease are still unclear. Therefore, the use of the metabolomics technique, due to the capability of identifying instantaneous metabolic perturbation, might help to recognize metabolic patterns associated with the cond…

MalePediatricsmedicine.medical_specialtyNeonatal intensive care unitBirth weightUrinary systemProton Magnetic Resonance SpectroscopymetaboliteGestational AgeDiseaseMetabolomicsSettore MED/38 - Pediatria Generale E SpecialisticaIntensive Care Units NeonatalmedicineHumansInfant Very Low Birth WeightMetabolomicsmultivariate statistical analysisbusiness.industryInfant Newborn1H-NMRObstetrics and GynecologyGestational agemedicine.diseaseBronchopulmonary dysplasiaLow birth weightBronchopulmonary dysplasiaPediatrics Perinatology and Child HealthMetabolomeFemalemedicine.symptombusinessBiomarkersInfant Prematuremetabolomic
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