0000000000003658

AUTHOR

Luigi Atzori

showing 3 related works from this author

1H-NMR-Based Metabolomics in Autism Spectrum Disorder and Pediatric Acute-Onset Neuropsychiatric Syndrome

2022

We recently described a unique plasma metabolite profile in subjects with pediatric acute-onset neuropsychiatric syndrome (PANS), suggesting pathogenic models involving specific patterns of neurotransmission, neuroinflammation, and oxidative stress. Here, we extend the analysis to a group of patients with autism spectrum disorder (ASD), as a consensus has recently emerged around its immune-mediated pathophysiology with a widespread involvement of brain networks. This observational case-control study enrolled patients referred for PANS and ASD from June 2019 to May 2020, as well as neurotypical age and gender-matched control subjects. Thirty-four PANS outpatients, fifteen ASD outpatients, an…

autism spectrum disorderGeneral Medicinebiomarkers’ evaluationpediatric acute-onset neuropsychiatric syndromepathways analysisSettore MED/39 - Neuropsichiatria Infantileautism spectrum disorder; pediatric acute-onset neuropsychiatric syndrome; metabolomics; biomarkers’ evaluation; pathways analysismetabolomicJournal of Clinical Medicine; Volume 11; Issue 21; Pages: 6493
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Urinary (1)H-NMR and GC-MS metabolomics predicts early and late onset neonatal sepsis.

2014

The purpose of this article is to study one of the most significant causes of neonatal morbidity and mortality: neonatal sepsis. This pathology is due to a bacterial or fungal infection acquired during the perinatal period. Neonatal sepsis has been categorized into two groups: early onset if it occurs within 3-6 days and late onset after 4-7 days. Due to the not-specific clinical signs, along with the inaccuracy of available biomarkers, the diagnosis is still a major challenge. In this regard, the use of a combined approach based on both nuclear magnetic resonance (H-1-NMR) and gas-chromatography-mass spectrometry (GC-MS) techniques, coupled with a multivariate statistical analysis, may hel…

Malemedicine.medical_specialtyPathologyMagnetic Resonance SpectroscopySepsiUrinary systemLate onsetMetabolomicDiseaseMass SpectrometrySepsisSettore MED/38 - Pediatria Generale E SpecialisticaInternal medicineSepsismedicineMetabolomeHumansNeonatal sepsisbusiness.industryCase-control studyInfant NewbornObstetrics and Gynecologymedicine.diseaseNewbornPrognosisCase-Control StudiesPediatrics Perinatology and Child HealthMetabolomePopulation studyFemalebusinessNeonatal infectionBiomarkersEarly human development
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Urinary metabolomics of bronchopulmonary dysplasia (BPD): preliminary data at birth suggest it is a congenital disease

2014

Abstract Objective: Bronchopulmonary dysplasia (BPD) or chronic lung disease is one of the principal causes of mortality and morbidity in preterm infants. Early identification of infants at the greater risk of developing BPD may allow a targeted approach for reducing disease severity and complications. The trigger cause of the disease comprehends the impairment of the alveolar development and the increased angiogenesis. Nevertheless, the molecular pathways characterizing the disease are still unclear. Therefore, the use of the metabolomics technique, due to the capability of identifying instantaneous metabolic perturbation, might help to recognize metabolic patterns associated with the cond…

MalePediatricsmedicine.medical_specialtyNeonatal intensive care unitBirth weightUrinary systemProton Magnetic Resonance SpectroscopymetaboliteGestational AgeDiseaseMetabolomicsSettore MED/38 - Pediatria Generale E SpecialisticaIntensive Care Units NeonatalmedicineHumansInfant Very Low Birth WeightMetabolomicsmultivariate statistical analysisbusiness.industryInfant Newborn1H-NMRObstetrics and GynecologyGestational agemedicine.diseaseBronchopulmonary dysplasiaLow birth weightBronchopulmonary dysplasiaPediatrics Perinatology and Child HealthMetabolomeFemalemedicine.symptombusinessBiomarkersInfant Prematuremetabolomic
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