0000000000004338

AUTHOR

Tom F. Lue

showing 3 related works from this author

The effect of intracavernosal growth differentiation factor-5 therapy in a rat model of cavernosal nerve injury.

2006

OBJECTIVE To determine whether the intracavernosal application of growth differentiation factor-5 (GDF-5) influences nerve regeneration and erectile function after cavernosal nerve injury in a rat model. MATERIALS AND METHODS Thirty-two male Sprague-Dawley rats were randomly divided into four equal groups: eight had a sham operation (uninjured controls), while 24 had bilateral cavernosal nerve crush. The crush-injury groups were treated at the time of injury with an impregnated collagen sponge implanted into the right corpus cavernosum. The sponge contained no GDF-5 (injured controls), 2 µg (low concentration), or 20 µg GDF-5 (high concentration). Erectile function was assessed by cavernosa…

NephrologyMalemedicine.medical_specialtyUrologyRat modelUrologyStimulationRats Sprague-DawleyRandom AllocationErectile DysfunctionGrowth Differentiation Factor 5Internal medicinemedicineAnimalsTrauma Nervous Systembusiness.industryGrowth differentiation factorNerve injurymedicine.diseaseNerve RegenerationRatsErectile dysfunctionEndocrinologyCollagen spongeNerve crushBone Morphogenetic Proteinsmedicine.symptombusinessPenisBJU international
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Hypertension and Impotence

1991

In a group of 472 impotent patients who were evaluated with pharmacologic duplex sonography, 117 patient (24.8%) had a history of hypertension, 26 of them (22.2%) for more than 10 years. Objective data about the changes in pulsation, diameter and blood flow velocity of the penile arteries after papaverine injection and the resulting erectile response allowed indirect assessment of the penile venous function. Varying degrees of impaired arterial function were diagnosed in 85% of the patients. The duration of hypertension had less deteriorating effects on the penile arterial system than second risk factors such as diabetes mellitus (n = 31) or smoking (n = 26). Patients on antihypertensive me…

MaleVenous leakmedicine.medical_specialtyUrologyErectile tissueVasodilationDiabetes ComplicationsErectile DysfunctionRisk FactorsPapaverineInternal medicineDiabetes mellitusmedicineHumansAntihypertensive AgentsPapaverinebusiness.industryPenile ErectionSmokingBlood flowMiddle Agedmedicine.diseaseSurgeryCompliance (physiology)medicine.anatomical_structureBlood pressureRegional Blood FlowHypertensionCardiologybusinessPenismedicine.drugEuropean Urology
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Castration and Erection

1988

Castrated dogs (n = 3) need a much higher threshold level of energy to induce erection by electrical stimulation of the cavernous nerve than noncastrated animals (n = 24). In addition the resulting quality of erection, measured as maximal intracavernous pressure (pCC) versus peak systolic blood pressure (BP), was weaker in castrated dogs (pCC = 57% of BP on average) than in noncastrated dogs (pCC = 80% of BP on average). A high venous outflow from the corpora cavernosa in castrated dogs can also explain the shorter duration of erection. This experimental model excludes the interference of subjective factors, such as erotic stimuli and libido on erection, and it seems that androgen deficienc…

Libidomedicine.medical_specialtybusiness.industryUrologyStimulationIntracavernous pressuremedicine.diseasechemistry.chemical_compoundEndocrinologyBlood pressureCastrationchemistrySmooth muscleInternal medicineAndrogen deficiencyMedicineAnimal studybusinessEuropean Urology
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