0000000000004397
AUTHOR
Minafra S.
Modulation of neoplastic phenotype by Extracellular Matrix components.
Proteomic modulation of breast cancer cells (8701-BC) cocultured with normal human fibroblasts.
Breast cancer proteomics: from research to clinical applications.
The exponentially increasing volume of information extracted from genomic and proteomic applications on cancer, while providing new insights into molecular composition of cancer cells and tissues, imposes new challenges on data rationalization as a tool for clinically relevant biomarker discovery. Breast cancer represents the most frequent and potentially aggressive type of cancer and, moreover, it is one of the most enigmatic and poorly predictable in its evolution, likely because it includes several different forms that behave differently among patients. Current clinical parameters for breast cancer diagnosis and cure are: tumour size, axillary lymph node status, histological grading and …