Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy

Objective: To evaluate the trends of colorectal cancer (CRC) incidence and mortality rates from 2003 to 2014 in Italy by age groups and regions. Methods: We used the data of 48 cancer registries from 17 Italian regions to estimate standardized incidence and mortality rates overall and by sex, age groups (<50, 50–69, 70+ years), and geographic area (northwest, northeast, center, south, and islands). Time trends were expressed as annual percent change in rates (APC) with 95% confidence intervals (95% CI). Results: Incidence rates decreased from 104.3 (2003) to 89.9 × 100,000 (2014) in men and from 64.3 to 58.4 × 100,000 in women. Among men, incidence decreased during 2007–2010 (APC −4.0, 9…

Appendix_1_-_Cancer_incidence_and_mortality_trends_in_the_Italy_revised – Supplemental material for Cancer incidence and mortality trends from 2003 to 2014 in Italy

Supplemental material, Appendix_1_-_Cancer_incidence_and_mortality_trends_in_the_Italy_revised for Cancer incidence and mortality trends from 2003 to 2014 in Italy by Carlotta Buzzoni, Emanuele Crocetti, Stefano Guzzinati, Luigino Dal Maso, Silvia Francisci, G Mazzoleni, MA Ferrara, E Caputo, E Coviello, R Galasso, A Citarella, G Sampietro, M Magoni, A Ardizzone, A D’Argenzio, A Sutera Sardo, A Giorno, G La Greca, P Ricci, S Ferretti, F Palma, D Serraino, S Iacovacci, A Melcarne, A Puppo, S Sciacca, AG Russo, Bianca Caruso, L Cavalieri d’Oro, G D’Orsi, M Fusco, M Usala, F Vitale, R Cusimano, M Michiara, L Boschetti, G Chiaranda, S Rosso, R Tumino, L Mangone, S Valenti Clemente, F Falcini, A…

The EUROCARE-5 study on cancer survival in Europe 1999-2007: Database, quality checks and statistical analysis methods

Abstract Background Since 25 years the EUROCARE study monitors the survival of cancer patients in Europe through centralised collection, quality check and statistical analysis of population-based cancer registries (CRs) data. The European population covered by the study increased remarkably in the latest round. The study design and statistical methods were also changed to improve timeliness and comparability of survival estimates. To interpret the EUROCARE-5 results on adult cancer patients better here we assess the impact of these changes on data quality and on survival comparisons. Methods In EUROCARE-5 the survival differences by area were studied applying the complete cohort approach to…

RISK OF HEMOLYMPHOPOIETIC NEOPLASM BEFORE AND AFTER THYROID CANCER. A POPULATION‐BASED STUDY IN ITALY, 1998‐2012

The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012

Aims: In Italy, incidence rates of thyroid cancer (TC) are among the highest world- wide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attribut- able to overdiagnosis. Methods: Data on TC cases reported to Italian cancer registries during 1998e2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region. Results: In Italy between 1998e2002 and 2008e2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (fro…

Italian cancer figures, report 2013: Multiple tumours

This collaborative study, based on data collected by the network of Italian association of cancer registries (AIRTUM), provides updated estimates on the incidence risk of multiple primary cancer (MP). The objective is to highlight and quantify the bidirectional associations between different oncological diseases. The quantification of the excess or decreased risk of further cancers in cancer patients, in comparison with the general population, may contribute to understand the aetiology of cancer and to address clinical follow-up.Data herein presented were provided by AIRTUM population-based cancer registries, which cover nowadays 48% of the Italian population. This monograph utilizes the AI…

Risk of thyroid as a first or second primary cancer. A population-based study in Italy, 1998–2012

Abstract Background The number of patients living after a cancer diagnosis is increasing, especially after thyroid cancer (TC). This study aims at evaluating both the risk of a second primary cancer (SPC) in TC patients and the risk of TC as a SPC. Methods We analyzed two population‐based cohorts of individuals with TC or other neoplasms diagnosed between 1998 and 2012, in 28 Italian areas covered by population‐based cancer registries. Standardized incidence ratios (SIRs) of SPC were stratified by sex, age, and time since first cancer. Results A total of 38,535 TC patients and 1,329,624 patients with other primary cancers were included. The overall SIR was 1.16 (95% CI: 1.12–1.21) for SPC i…

Cancer incidence and mortality trends from 2003 to 2014 in Italy.

Objective: To evaluate short-term (2003–2014) cancer incidence and mortality trends in Italy. Methods: Italian Cancer Registries data, available in the AIRTUM database, from 17 out of 20 regions were used. The number of incident cases and deaths were estimated for those registries and those years with incomplete information. Age-standardized rates, overall and stratified by geographic area, region, sex, cancer site, and major age group, were computed. Time trends were expressed as annual percent change of rates. Results: In Italy, among males, incidence rates for all cancers showed during 2003–2014, a significant decrease (−0.9%/year), with stronger reductions in the northwest (−1.3%/year) …

Supplement-Figure-1.DPI_300 – Supplemental material for Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy

Supplemental material, Supplement-Figure-1.DPI_300 for Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy by Manuel Zorzi, Luigino Dal Maso, Silvia Francisci, Carlotta Buzzoni, Massimo Rugge, Stefano Guzzinati, G. Mazzoleni, E. Coviello, R. Galasso, G. Sampietro, M. Magoni, A. Ardizzone, A. D‘Argenzio, A. Sutera Sardo, A. Giorno, G. La Greca, P. Ricci, S. Ferretti, F. Palma, D. Serraino, S. Iacovacci, A. Melcarne, A. Puppo, S. Sciacca, A.G. Russo, B. Caruso, L. Cavalieri d’Oro, G. D‘Orsi, M. Fusco, M. Usala, F. Vitale, R. Cusimano, M. Michiara, L. Boschetti, G. Chiaranda, S. Rosso, R. Tumino, L. Mangone, F. Falcini, A.L. Caiazzo, R. Cesaraccio, F. Tisano, A…

Supplement-Figure-2.DPI_300 – Supplemental material for Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy

Supplemental material, Supplement-Figure-2.DPI_300 for Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy by Manuel Zorzi, Luigino Dal Maso, Silvia Francisci, Carlotta Buzzoni, Massimo Rugge, Stefano Guzzinati, G. Mazzoleni, E. Coviello, R. Galasso, G. Sampietro, M. Magoni, A. Ardizzone, A. D‘Argenzio, A. Sutera Sardo, A. Giorno, G. La Greca, P. Ricci, S. Ferretti, F. Palma, D. Serraino, S. Iacovacci, A. Melcarne, A. Puppo, S. Sciacca, A.G. Russo, B. Caruso, L. Cavalieri d’Oro, G. D‘Orsi, M. Fusco, M. Usala, F. Vitale, R. Cusimano, M. Michiara, L. Boschetti, G. Chiaranda, S. Rosso, R. Tumino, L. Mangone, F. Falcini, A.L. Caiazzo, R. Cesaraccio, F. Tisano, A…