6533b834fe1ef96bd129e259
RESEARCH PRODUCT
The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012
Giuseppe SampietroAlessio GiliAnselmo MadedduCinzia GasparottiChiara PanatoIvan ComettiSalvatore VaccarellaSilvano PifferMartina TaborelliLuigino Dal MasoFabio FalciniMaria MichiaraDiego SerrainoEugenia SpataWalter MazzuccoStefano FerrettiAlessandra RavaioliAntonietta TorrisiRosanna CusimanoD PirinoMario FuscoGiulio BarigellettiSanto ScalziLuca Cavalieri D'oroSusanna BuscoMichele MagoniMassimo VarvaràPaolo RicciGianmaria PennelliS PatriarcaLuciana GattiMassimo VicentiniClaudia CirilliGiorgia StoppaAnna Luisa CaiazzoAndreas BulatkoM UsalaManuel ZorziAntonio RussoStefano RossoGiuseppina CandelaLucia MangoneRoberto RizzelloSilvia LeiteRosario TuminoRosaria CesaraccioA.c. FanettiGiovanna TagliabueAdele CaldarellaGuido MazzoleniA. PuppoPier Carlo VercellinoCarlotta BuzzoniF TisanoFrancesco CuccaroLinda GuardaMaria Francesca VitaleGianfranco ManneschiFabio PannozzoRoberto ZanettiFrancesca GaspariniAnna MelcarneGiovanna Maria SiniPaolo SgargiUgo FedeliRosa FilibertiPaolo CollarileArturo IannelliSimona CaroneKatia VallaElisabetta BorcianiG GolaSilvia Franceschisubject
MaleCancer ResearchMedical OveruseSettore MED/42 - Igiene Generale E Applicata0302 clinical medicineRegistriesYoung adultOverdiagnosisChildThyroid cancerAged 80 and overeducation.field_of_studyIncidence (epidemiology)IncidenceThyroidTime trendsMiddle Agedmedicine.anatomical_structureOncologyItaly030220 oncology & carcinogenesisChild PreschoolFemalemedicine.symptomAdultIncidence; Italy; Mortality; Overdiagnosis; Thyroid cancer; Time trends; Oncology; Cancer ResearchOverdiagnosisAdolescentPopulationSocio-culturale030209 endocrinology & metabolismAsymptomaticThyroid cancer03 medical and health sciencesYoung AdultmedicineHumansThyroid NeoplasmsMortalityeducationEpidemicsAgedbusiness.industryInfant NewbornCancerInfantmedicine.diseaseOverdiagnosibusinessDemographydescription
Aims: In Italy, incidence rates of thyroid cancer (TC) are among the highest world- wide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attribut- able to overdiagnosis. Methods: Data on TC cases reported to Italian cancer registries during 1998e2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region. Results: In Italy between 1998e2002 and 2008e2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC (þ91% in women, þ120% in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998e2012 in Italy, we estimated that overdiagnosis accounted for 75% of cases in women and 63% in men and increased over the study period leading to overdiagnosis of 79% in women and 67% in men in 2008e2012. Notably, overdiagnosis was over 80% among women aged <55 years, and substantial variations were documented across Italian regions, in both genders. Conclusion(s): Incidence rates of TC are steadily increasing in Italy and largely due to over- diagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels. a 2018 Elsevier Ltd. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |