Cancer cure for 32 cancer types: results from the EUROCARE-5 study

Abstract Background Few studies have estimated the probability of being cured for cancer patients. This study aims to estimate population-based indicators of cancer cure in Europe by type, sex, age and period. Methods 7.2 million cancer patients (42 population-based cancer registries in 17 European countries) diagnosed at ages 15–74 years in 1990–2007 with follow-up to 2008 were selected from the EUROCARE-5 dataset. Mixture-cure models were used to estimate: (i) life expectancy of fatal cases (LEF); (ii) cure fraction (CF) as proportion of patients with same death rates as the general population; (iii) time to cure (TTC) as time to reach 5-year conditional relative survival (CRS) >95…

Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy

Objective: To evaluate the trends of colorectal cancer (CRC) incidence and mortality rates from 2003 to 2014 in Italy by age groups and regions. Methods: We used the data of 48 cancer registries from 17 Italian regions to estimate standardized incidence and mortality rates overall and by sex, age groups (<50, 50–69, 70+ years), and geographic area (northwest, northeast, center, south, and islands). Time trends were expressed as annual percent change in rates (APC) with 95% confidence intervals (95% CI). Results: Incidence rates decreased from 104.3 (2003) to 89.9 × 100,000 (2014) in men and from 64.3 to 58.4 × 100,000 in women. Among men, incidence decreased during 2007–2010 (APC −4.0, 9…

RISK OF HEMOLYMPHOPOIETIC NEOPLASM BEFORE AND AFTER THYROID CANCER. A POPULATION‐BASED STUDY IN ITALY, 1998‐2012

The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012

Aims: In Italy, incidence rates of thyroid cancer (TC) are among the highest world- wide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attribut- able to overdiagnosis. Methods: Data on TC cases reported to Italian cancer registries during 1998e2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region. Results: In Italy between 1998e2002 and 2008e2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (fro…

Patterns of care and cost profiles of women with breast cancer in Italy: EPICOST study based on real world data

Objectives To estimate total direct health care costs associated to diagnosis and treatment of women with breast cancer in Italy, and to investigate their distribution by service type according to the disease pathway and patient characteristics. Methods Data on patients provided by population-based Cancer Registries are linked at individual level with data on health-care services and corresponding claims from administrative databases. A combination of cross-sectional approach and a threephase of care decomposition model with initial, continuing and final phases-of-care defined according to time occurred since diagnosis and disease outcome is adopted. Direct estimation of cancer-related cost…

Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000–14 (CONCORD-3): analysis of individual data from 258 cancer registries in 61 countries

BACKGROUND Leukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed data for children (aged 0-14 years) and adults (aged 15-99 years) diagnosed with a haematological malignancy during 2000-14 in 61 countries. Here, we aimed to examine worldwide trends in survival from leukaemia, by age and morphology, in young patients (aged 0-24 years). METHODS We analysed data from 258 population-based cancer registries in 61 countries participating in CONCORD-3 that submitted data on patients diagnosed with leukaemia. We grouped patients by age as children (0-14 years), adolescents (15-19 years), and young adults (20-24 years). We categorised leukaemia subtypes a…

Risk of thyroid as a first or second primary cancer. A population-based study in Italy, 1998–2012

Abstract Background The number of patients living after a cancer diagnosis is increasing, especially after thyroid cancer (TC). This study aims at evaluating both the risk of a second primary cancer (SPC) in TC patients and the risk of TC as a SPC. Methods We analyzed two population‐based cohorts of individuals with TC or other neoplasms diagnosed between 1998 and 2012, in 28 Italian areas covered by population‐based cancer registries. Standardized incidence ratios (SIRs) of SPC were stratified by sex, age, and time since first cancer. Results A total of 38,535 TC patients and 1,329,624 patients with other primary cancers were included. The overall SIR was 1.16 (95% CI: 1.12–1.21) for SPC i…

Impact of screening programme using the faecal immunochemical test on stage of colorectal cancer: Results from the IMPATTO study

To evaluate the impact of faecal immunochemical test (FIT) screening on stage distribution at diagnosis, and to estimate relative incidence rates by stage in screened at first and subsequent rounds vs. unscreened. We included all incident cases occurring in 2000-2008 in 50- to 71-year-olds residing in areas with an FIT-screening programme. Multinomial logistic models were computed to estimate the relative risk ratio (RRR) of stages I and IV, compared to stage II + III, adjusting for age, sex, geographical area, and incidence year. Proportions were then used to estimate incidence rate ratios (IRR) by stage for screened subjects at the first and at subsequent rounds vs. unscreened subjects, a…

Supplement-Figure-1.DPI_300 – Supplemental material for Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy

Supplemental material, Supplement-Figure-1.DPI_300 for Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy by Manuel Zorzi, Luigino Dal Maso, Silvia Francisci, Carlotta Buzzoni, Massimo Rugge, Stefano Guzzinati, G. Mazzoleni, E. Coviello, R. Galasso, G. Sampietro, M. Magoni, A. Ardizzone, A. D‘Argenzio, A. Sutera Sardo, A. Giorno, G. La Greca, P. Ricci, S. Ferretti, F. Palma, D. Serraino, S. Iacovacci, A. Melcarne, A. Puppo, S. Sciacca, A.G. Russo, B. Caruso, L. Cavalieri d’Oro, G. D‘Orsi, M. Fusco, M. Usala, F. Vitale, R. Cusimano, M. Michiara, L. Boschetti, G. Chiaranda, S. Rosso, R. Tumino, L. Mangone, F. Falcini, A.L. Caiazzo, R. Cesaraccio, F. Tisano, A…

Supplement-Figure-2.DPI_300 – Supplemental material for Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy

Supplemental material, Supplement-Figure-2.DPI_300 for Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy by Manuel Zorzi, Luigino Dal Maso, Silvia Francisci, Carlotta Buzzoni, Massimo Rugge, Stefano Guzzinati, G. Mazzoleni, E. Coviello, R. Galasso, G. Sampietro, M. Magoni, A. Ardizzone, A. D‘Argenzio, A. Sutera Sardo, A. Giorno, G. La Greca, P. Ricci, S. Ferretti, F. Palma, D. Serraino, S. Iacovacci, A. Melcarne, A. Puppo, S. Sciacca, A.G. Russo, B. Caruso, L. Cavalieri d’Oro, G. D‘Orsi, M. Fusco, M. Usala, F. Vitale, R. Cusimano, M. Michiara, L. Boschetti, G. Chiaranda, S. Rosso, R. Tumino, L. Mangone, F. Falcini, A.L. Caiazzo, R. Cesaraccio, F. Tisano, A…