0000000000006381
AUTHOR
Clara Sofie Bratholm
Drug resistance is widespread among children who receive long-term antiretroviral treatment at a rural Tanzanian hospital
Published version of an article from the journal: Journal of Antimicrobial Chemotherapy. Also available from the publisher: htttp://dx.doi.org/10.1093/jac/dkq234 Objectives: To assess long-term virological efficacy and the emergence of drug resistance in children who receive antiretroviral treatment (ART) in rural Tanzania. Patients and methods: Haydom Lutheran Hospital has provided ART to HIV-infected individuals since 2003. From February through May 2009, a cross-sectional virological efficacy survey was conducted among children (, 15 years) who had completed >= 6 months of first-line non-nucleoside reverse transcriptase inhibitor (NNRTI)-based ART. Genotypic resistance was determined in …
Drug resistance is widespread among children who receive long-term antiretroviral treatment at a rural Tanzanian hospital
Drug resistance is widespread among children who receive long-term antiretroviral treatment in rural Tanzania. Objectives: Long-term virological response to pediatric antiretroviral treatment (ART) in rural Africa is poorly described. We examined virological efficacy and genotypic resistance in children who received first-line ART for up to 5 years in rural Tanzania. Methods: Haydom Lutheran Hospital has provided ART to HIV-infected children since 2003. A combination of stavudine or zidovudine with lamivudine and either nevirapine or efavirenz is the standard regimen; however, fixed-dose combinations for children have not been available until recently. From February through May 2009 we carr…