0000000000006381

AUTHOR

Clara Sofie Bratholm

showing 2 related works from this author

Drug resistance is widespread among children who receive long-term antiretroviral treatment at a rural Tanzanian hospital

2010

Published version of an article from the journal: Journal of Antimicrobial Chemotherapy. Also available from the publisher: htttp://dx.doi.org/10.1093/jac/dkq234 Objectives: To assess long-term virological efficacy and the emergence of drug resistance in children who receive antiretroviral treatment (ART) in rural Tanzania. Patients and methods: Haydom Lutheran Hospital has provided ART to HIV-infected individuals since 2003. From February through May 2009, a cross-sectional virological efficacy survey was conducted among children (, 15 years) who had completed >= 6 months of first-line non-nucleoside reverse transcriptase inhibitor (NNRTI)-based ART. Genotypic resistance was determined in …

MaleRural Populationsub-Saharan AfricaMicrobiology (medical)medicine.medical_specialtyAdolescentGenotypeantiretroviral therapyPopulationVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Communicable diseases: 776Drug resistanceTanzaniaPharmacotherapyAcquired immunodeficiency syndrome (AIDS)Drug Resistance ViralAntimicrobial chemotherapyPrevalencemedicineHumansPharmacology (medical)educationOriginal ResearchPharmacologychildeducation.field_of_studyVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801biologybusiness.industryHIVLamivudineViral Loadbiology.organism_classificationmedicine.diseaseHospitalsCross-Sectional StudiesInfectious DiseasesTanzaniaAnti-Retroviral AgentsChild PreschoolFamily medicineImmunologyFemaleVDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801Rural areabusinessHIV infectionsmedicine.drugJournal of Antimicrobial Chemotherapy
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Drug resistance is widespread among children who receive long-term antiretroviral treatment at a rural Tanzanian hospital

2010

Drug resistance is widespread among children who receive long-term antiretroviral treatment in rural Tanzania. Objectives: Long-term virological response to pediatric antiretroviral treatment (ART) in rural Africa is poorly described. We examined virological efficacy and genotypic resistance in children who received first-line ART for up to 5 years in rural Tanzania. Methods: Haydom Lutheran Hospital has provided ART to HIV-infected children since 2003. A combination of stavudine or zidovudine with lamivudine and either nevirapine or efavirenz is the standard regimen; however, fixed-dose combinations for children have not been available until recently. From February through May 2009 we carr…

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