6533b7d6fe1ef96bd126722b
RESEARCH PRODUCT
Drug resistance is widespread among children who receive long-term antiretroviral treatment at a rural Tanzanian hospital
Svein Gunnar GundersenJohan N. BruunJohan N. BruunJohan N. BruunMona Holberg-petersenEzra NamanSokoine KivuyoVidar OrmaasenClara Sofie BratholmAsgeir Johannessensubject
MaleRural Populationsub-Saharan AfricaMicrobiology (medical)medicine.medical_specialtyAdolescentGenotypeantiretroviral therapyPopulationVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Communicable diseases: 776Drug resistanceTanzaniaPharmacotherapyAcquired immunodeficiency syndrome (AIDS)Drug Resistance ViralAntimicrobial chemotherapyPrevalencemedicineHumansPharmacology (medical)educationOriginal ResearchPharmacologychildeducation.field_of_studyVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801biologybusiness.industryHIVLamivudineViral Loadbiology.organism_classificationmedicine.diseaseHospitalsCross-Sectional StudiesInfectious DiseasesTanzaniaAnti-Retroviral AgentsChild PreschoolFamily medicineImmunologyFemaleVDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801Rural areabusinessHIV infectionsmedicine.drugdescription
Published version of an article from the journal: Journal of Antimicrobial Chemotherapy. Also available from the publisher: htttp://dx.doi.org/10.1093/jac/dkq234 Objectives: To assess long-term virological efficacy and the emergence of drug resistance in children who receive antiretroviral treatment (ART) in rural Tanzania. Patients and methods: Haydom Lutheran Hospital has provided ART to HIV-infected individuals since 2003. From February through May 2009, a cross-sectional virological efficacy survey was conducted among children (, 15 years) who had completed >= 6 months of first-line non-nucleoside reverse transcriptase inhibitor (NNRTI)-based ART. Genotypic resistance was determined in those with a viral load of >200 copies/mL. Results: Virological response was measured in 19 of 23 eligible children; 8 of 19 were girls and median age at ART initiation was 5 years (range 2-14 years). Median duration of ART at the time of the survey was 40 months (range 11-61 months). Only 8 children were virologically suppressed (50% harboured drug resistance. Results for children were markedly poorer than for adults attending the same programme, underscoring the need for improved treatment strategies for children in resource-limited settings.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-01-01 | Journal of Antimicrobial Chemotherapy |