0000000000289222

AUTHOR

Sokoine Kivuyo

showing 2 related works from this author

Drug resistance is widespread among children who receive long-term antiretroviral treatment at a rural Tanzanian hospital

2010

Published version of an article from the journal: Journal of Antimicrobial Chemotherapy. Also available from the publisher: htttp://dx.doi.org/10.1093/jac/dkq234 Objectives: To assess long-term virological efficacy and the emergence of drug resistance in children who receive antiretroviral treatment (ART) in rural Tanzania. Patients and methods: Haydom Lutheran Hospital has provided ART to HIV-infected individuals since 2003. From February through May 2009, a cross-sectional virological efficacy survey was conducted among children (, 15 years) who had completed >= 6 months of first-line non-nucleoside reverse transcriptase inhibitor (NNRTI)-based ART. Genotypic resistance was determined in …

MaleRural Populationsub-Saharan AfricaMicrobiology (medical)medicine.medical_specialtyAdolescentGenotypeantiretroviral therapyPopulationVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Communicable diseases: 776Drug resistanceTanzaniaPharmacotherapyAcquired immunodeficiency syndrome (AIDS)Drug Resistance ViralAntimicrobial chemotherapyPrevalencemedicineHumansPharmacology (medical)educationOriginal ResearchPharmacologychildeducation.field_of_studyVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801biologybusiness.industryHIVLamivudineViral Loadbiology.organism_classificationmedicine.diseaseHospitalsCross-Sectional StudiesInfectious DiseasesTanzaniaAnti-Retroviral AgentsChild PreschoolFamily medicineImmunologyFemaleVDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801Rural areabusinessHIV infectionsmedicine.drugJournal of Antimicrobial Chemotherapy
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Virological efficacy and emergence of drug resistance in adults on antiretroviral treatment in rural Tanzania

2009

Background Virological response to antiretroviral treatment (ART) in rural Africa is poorly described. We examined virological efficacy and emergence of drug resistance in adults receiving first-line ART for up to 4 years in rural Tanzania. Methods Haydom Lutheran Hospital has provided ART to HIV-infected patients since October 2003. A combination of stavudine or zidovudine with lamivudine and either nevirapine or efavirenz is the standard first-line regimen. Nested in a longitudinal cohort study of patients consecutively starting ART, we carried out a cross-sectional virological efficacy survey between November 2007 and June 2008. HIV viral load was measured in all adults who had completed…

AdultMalemedicine.medical_specialtyNevirapineEfavirenzTime FactorsAnti-HIV AgentsHIV InfectionsVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Communicable diseases: 776Drug resistanceTanzanialcsh:Infectious and parasitic diseasesCohort StudiesZidovudinechemistry.chemical_compoundInternal medicineDrug Resistance ViralmedicineHumanslcsh:RC109-216Viremiabusiness.industryStavudineLamivudineResistance mutationVirologyInfectious DiseasesCross-Sectional StudieschemistryHIV-1FemalebusinessViral loadmedicine.drugResearch Article
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