Search results for "Pharmacology"
showing 10 items of 8885 documents
Multiple Solutions for Fractional Boundary Value Problems
2018
Variational methods and critical point theorems are used to discuss existence and multiplicity of solutions for fractional boundary value problem where Riemann–Liouville fractional derivatives and Caputo fractional derivatives are used. Some conditions to determinate nonnegative solutions are presented. An example is given to illustrate our results.
Corrosion of Welded Metal Structures of Mining Equipment
2018
Mining equipment made of welded metal structures is strongly affected by the corrosion phenomenon due to the working conditions. Initial research has shown that the corrosion phenomenon is most pronounced in the area of cross-welded joints and welded T-shaped joints. In the researches, there was made a chemical analysis of the welded construction material used respectively of the new material and it was observed a reduction in carbon concentration in the material used, but also a substantial increase in the sulfur concentration compared to the new material. The pronounced corrosion of the metallic structure is influenced by the chemical composition change because the sulfur is a grafitizin…
Fluorine-Containing Drugs Approved by the FDA in 2018
2019
Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster drugs) contain fluorine atoms. In this review, we profile 17 fluorine-containing drugs approved by the food and drug administration (FDA) in 2018. The newly approved pharmaceuticals feature several types of aromatic F and CF3 , as well as aliphatic (CF2 ) substitution, offering advances in the treatment of various diseases, including cancer, HIV, malarial and smallpox infections.
Diabetes and renin-angiotensin-aldosterone system: Implications for covid-19 patients with diabetes treatment management
2020
In the context of the COVID-19 continuous spreading, this paper focuses on the increased risk of diabetic patients regarding the metabolic control and the uncertainties related to SARS-CoV-2 infection. Chronic hyperglycaemia negatively affects the immune system, which triggers an increase of morbidity and mortality for viral infections. A key aspect of COVID-19 resides in the involvement of renin-angiotensin-aldosterone (RAAS) system that causes a cascade of reactions mediated by vasoactive peptides with implications in vasoconstriction, vascular permeability, oxidative stress remodelling and tissue injuries. Activation of RAAS at pulmonary level, is responsible for the local damage. Many q…
Du Néolithique récent à l’âge du Bronze dans le Centre Nord de la France : les étapes de l’évolution chrono-culturelle
2011
Die seit 2001 im Rahmen eines PCR (Programme Collectif Régional) durchgeführte Gemeinschaftsarbeit über das Ende des Neolithikums und den Beginns der Bronzezeit im Zentrum Nordfrankreichs führt heute zu einer neuen Periodisierung der Zeit zwischen 3600 und 1800 v. Chr. in acht Etappen. Obwohl, insbesondere bezüglich der Transition zwischen dem Mittel-und dem Jungneolithikum einerseits und dem Jung-und dem Endneolithikum andererseits, auch weiterhin einige Lücken bestehen, erlaubt dieser präzisere Rahmen die Hauptetappen im Zentrum Nordfrankreichs mit denen der benachbarten Regionen zu synchronisieren, um eine dynamischere Vision der kulturellen Phänomene vorzuschlagen.
La tombe à chars d'Évergnicourt (Aisne), "Le Tournant du Chêne"
2005
Lambot Bernard, Méniel Patrice. La tombe à chars d'Évergnicourt (Aisne), "Le Tournant du Chêne". In: Revue archéologique de Picardie. Numéro spécial 22, 2005. Hommages à Claudine Pommepuy. pp. 327-354.
Cnidarian Interaction with Microbial Communities: From Aid to Animal’s Health to Rejection Responses
2018
The phylum Cnidaria is an ancient branch in the tree of metazoans. Several species exert a remarkable longevity, suggesting the existence of a developed and consistent defense mechanism of the innate immunity capable to overcome the potential repeated exposure to microbial pathogenic agents. Increasing evidence indicates that the innate immune system in Cnidarians is not only involved in the disruption of harmful microorganisms, but also is crucial in structuring tissue-associated microbial communities that are essential components of the Cnidarian holobiont and useful to the animal’s health for several functions, including metabolism, immune defense, development, and behavior. Someti…
Neurosporaxanthin Overproduction by Fusarium fujikuroi and Evaluation of Its Antioxidant Properties
2020
17 Páginas.-- 5 Figuras
Lipid Nanoparticles as Potential Gene Therapeutic Delivery Systems for Oral Administration.
2017
Background Gene therapy has experimented an increasing attention in the last decades, due to its enormous potential applications in the medical field. It can be defined as the use of genes or genetic material (DNA, RNA, oligonucleotides) to treat or prevent a disease state, generally a geneticbased one. Application Other applications, like treating viral, bacterial or parasite infections or development of vaccines are gaining also interest. Efficient gene therapy is mainly dependent on the ability of the highly labile genetic material to reach the therapeutic target. For this purpose, different delivery systems have been designed and extensively investigated. Nanoparticles offer a broad ran…
2021
Environmental heterogeneity is a central component influencing the virulence and epidemiology of infectious diseases. The number and distribution of susceptible hosts determines disease transmission opportunities, shifting the epidemiological threshold between the spread and fadeout of a disease. Similarly, the presence and diversity of other hosts, pathogens and environmental microbes, may inhibit or accelerate an epidemic. This has important applied implications in farming environments, where high numbers of susceptible hosts are maintained in conditions of minimal environmental heterogeneity. We investigated how the quantity and quality of aquaculture enrichments (few vs. many stones; cl…