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RESEARCH PRODUCT
Fluorine-Containing Drugs Approved by the FDA in 2018
Mercedes Medio-simónSantos FusteroDaniel M. SedgwickHaibo MeiJianlin HanClaudio SantiRenzo RuzziconiVadim A. SoloshonokVadim A. Soloshonoksubject
010405 organic chemistryChemistryUnited States Food and Drug AdministrationOrganic ChemistryHuman immunodeficiency virus (HIV)Fluorine containingGeneral ChemistryPharmacology010402 general chemistrymedicine.disease_causesynthesis:01 natural sciencesCatalysisUnited Statesdrugs0104 chemical sciencesFood and drug administrationfluorinemedicineHumansfluorine; synthesis: drugsdescription
Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster drugs) contain fluorine atoms. In this review, we profile 17 fluorine-containing drugs approved by the food and drug administration (FDA) in 2018. The newly approved pharmaceuticals feature several types of aromatic F and CF3 , as well as aliphatic (CF2 ) substitution, offering advances in the treatment of various diseases, including cancer, HIV, malarial and smallpox infections.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-04-22 |