0000000000256077

AUTHOR

Renzo Ruzziconi

showing 4 related works from this author

Frontispiece: Fluorine‐Containing Drugs Approved by the FDA in 2018

2019

Substitution reactionChemistryOrganic ChemistryHuman immunodeficiency virus (HIV)Cancerchemistry.chemical_elementFluorine containingGeneral Chemistrymedicine.diseasemedicine.disease_causeCombinatorial chemistryCatalysismedicineFluorineChemistry – A European Journal
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Recent progress in the application of fluorinated chiral sulfinimine reagents

2018

Abstract The development of synthetic methodology allowing for a strategic incorporation of fluorine into target compounds is in a high demand in many areas of the chemical and pharmaceutical industries. In this regard, application of fluorinated chiral sulfinimine reagents, in particularly, N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimine, is one of the most general and practical approaches for preparation of compounds containing pharmacophoric fluoro-amino-keto/hydroxy moieties. This article provides a timely and comprehensive overview of the recent synthetic applications of fluorinated chiral sulfinimine reagents for asymmetric synthesis of fluoro-containing polyfunctional amino-compound…

010405 organic chemistryChemistryOrganic ChemistryEnantioselective synthesisAsymmetric synthesisFluoro-imineAmino compounds010402 general chemistry01 natural sciencesBiochemistryCombinatorial chemistry0104 chemical sciencesInorganic ChemistrySulfinimineReagentEnvironmental ChemistryPhysical and Theoretical ChemistryAmino compounds; Asymmetric synthesis; Fluoro-imine; Sulfinimine; Biochemistry; Environmental Chemistry; Physical and Theoretical Chemistry; Organic Chemistry; Inorganic ChemistryJournal of Fluorine Chemistry
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Chemistry of detrifluoroacetylativelyin situgenerated fluoro-enolates

2018

This review article comprehensively profiles all literature reports (2015-2018) related to the detrifluoroacetylative in situ generation of fluorine-containing enolates and their reactions with electrophilic reagents. The innovative facets of this unconventional methodology and its synthetic generality for the preparation of fluorine-containing compounds of high medicinal value are highlighted.

In situ010405 organic chemistryChemistryOrganic Chemistry010402 general chemistryfloroorganic compound01 natural sciencesBiochemistryCombinatorial chemistryalfa-fluoroenolates0104 chemical sciencesElectrophileDetrifluoroacetylationPhysical and Theoretical ChemistryValue (mathematics)Detrifluoroacetylation floroorganic compound alfa-fluoroenolates.Organic & Biomolecular Chemistry
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Fluorine-Containing Drugs Approved by the FDA in 2018

2019

Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster drugs) contain fluorine atoms. In this review, we profile 17 fluorine-containing drugs approved by the food and drug administration (FDA) in 2018. The newly approved pharmaceuticals feature several types of aromatic F and CF3 , as well as aliphatic (CF2 ) substitution, offering advances in the treatment of various diseases, including cancer, HIV, malarial and smallpox infections.

010405 organic chemistryChemistryUnited States Food and Drug AdministrationOrganic ChemistryHuman immunodeficiency virus (HIV)Fluorine containingGeneral ChemistryPharmacology010402 general chemistrymedicine.disease_causesynthesis:01 natural sciencesCatalysisUnited Statesdrugs0104 chemical sciencesFood and drug administrationfluorinemedicineHumansfluorine; synthesis: drugs
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