Chemistry of detrifluoroacetylativelyin situgenerated fluoro-enolates

6533b7dafe1ef96bd126e14a

RESEARCH PRODUCT

Chemistry of detrifluoroacetylativelyin situgenerated fluoro-enolates

Jianlin Han Vadim A. Soloshonok Vadim A. Soloshonok Santos Fustero Raquel Román Haibo Mei Jiang Liu Renzo Ruzziconi

subject

In situ 010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry floroorganic compound 01 natural sciences Biochemistry Combinatorial chemistry alfa-fluoroenolates 0104 chemical sciences Electrophile Detrifluoroacetylation Physical and Theoretical Chemistry Value (mathematics)Detrifluoroacetylation floroorganic compound alfa-fluoroenolates.

description

This review article comprehensively profiles all literature reports (2015-2018) related to the detrifluoroacetylative in situ generation of fluorine-containing enolates and their reactions with electrophilic reagents. The innovative facets of this unconventional methodology and its synthetic generality for the preparation of fluorine-containing compounds of high medicinal value are highlighted.

year	journal	country	edition	language
2018-12-24	Organic & Biomolecular Chemistry

https://doi.org/10.1039/c8ob02843e

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