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RESEARCH PRODUCT
Diabetes and renin-angiotensin-aldosterone system: Implications for covid-19 patients with diabetes treatment management
Antonio CerielloViorel JingaGabriela IorgulescuCristian SerafinceanuDenisa Ioana UdeanuDoina CatrinoiuAnca Pantea-stoianIon-bogdan DumitrescuNicola MontanoManfredi RizzoManfredi Rizzosubject
010405 organic chemistrybusiness.industry030209 endocrinology & metabolismContext (language use)Vascular permeabilityACEi ARBs COVID-19 Diabetes Of renin-angiotensin-aldosterone system RAAS SARS-CoV-2medicine.diseasemedicine.disease_causeBioinformatics01 natural sciences0104 chemical sciences03 medical and health sciences0302 clinical medicineImmune systemMetabolic control analysisDiabetes mellitusRenin–angiotensin systemmedicineGeneral Pharmacology Toxicology and Pharmaceuticsmedicine.symptombusinessVasoconstrictionOxidative stressdescription
In the context of the COVID-19 continuous spreading, this paper focuses on the increased risk of diabetic patients regarding the metabolic control and the uncertainties related to SARS-CoV-2 infection. Chronic hyperglycaemia negatively affects the immune system, which triggers an increase of morbidity and mortality for viral infections. A key aspect of COVID-19 resides in the involvement of renin-angiotensin-aldosterone (RAAS) system that causes a cascade of reactions mediated by vasoactive peptides with implications in vasoconstriction, vascular permeability, oxidative stress remodelling and tissue injuries. Activation of RAAS at pulmonary level, is responsible for the local damage. Many questions regarding the treatment with ACE inhibitors and angiotensin receptor blockers were raised considering the correlation between RAAS and viral infection in diabetic patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-06-22 |