0000000000008757

AUTHOR

Eric Ceballos

showing 2 related works from this author

Enantioselective addition of terminal alkynes to N-(diphenylphosphinoyl)imines catalyzed by Zn–BINOL complexes

2012

Abstract Chiral nonracemic N-(diphenylphosphinoyl)-protected propargylic amines have been prepared by addition of terminal alkynes to N-(diphenylphosphinoyl)aldimines in the presence of dimethylzinc and 3,3′-dibromo-BINOL as catalyst. The reaction works with a variety of aromatic and heteroaromatic aldimines and with different alkynes, providing the expected products in generally good yields and enantiomeric excesses (up to 96%).

chemistry.chemical_classificationAldiminechemistry.chemical_compoundchemistryOrganic ChemistryDrug DiscoveryDimethylzincEnantioselective synthesisEnantiomerBiochemistryMedicinal chemistryCatalysisTetrahedron
researchProduct

ChemInform Abstract: Enantioselective Addition of Terminal Alkynes to N-(Diphenylphosphinoyl)imines Catalyzed by Zn-BINOL Complexes.

2012

Abstract Chiral nonracemic N-(diphenylphosphinoyl)-protected propargylic amines have been prepared by addition of terminal alkynes to N-(diphenylphosphinoyl)aldimines in the presence of dimethylzinc and 3,3′-dibromo-BINOL as catalyst. The reaction works with a variety of aromatic and heteroaromatic aldimines and with different alkynes, providing the expected products in generally good yields and enantiomeric excesses (up to 96%).

chemistry.chemical_classificationAldimineAddition reactionchemistry.chemical_compoundchemistryDimethylzincEnantioselective synthesisOrganic chemistryGeneral MedicineEnantiomerMedicinal chemistryCatalysisChemInform
researchProduct