6533b85bfe1ef96bd12ba960
RESEARCH PRODUCT
ChemInform Abstract: Enantioselective Addition of Terminal Alkynes to N-(Diphenylphosphinoyl)imines Catalyzed by Zn-BINOL Complexes.
José R. PedroAlicia MonleonEric CeballosGonzalo Blaysubject
chemistry.chemical_classificationAldimineAddition reactionchemistry.chemical_compoundchemistryDimethylzincEnantioselective synthesisOrganic chemistryGeneral MedicineEnantiomerMedicinal chemistryCatalysisdescription
Abstract Chiral nonracemic N-(diphenylphosphinoyl)-protected propargylic amines have been prepared by addition of terminal alkynes to N-(diphenylphosphinoyl)aldimines in the presence of dimethylzinc and 3,3′-dibromo-BINOL as catalyst. The reaction works with a variety of aromatic and heteroaromatic aldimines and with different alkynes, providing the expected products in generally good yields and enantiomeric excesses (up to 96%).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-07-03 | ChemInform |