0000000000009410
AUTHOR
Gudrun Bernhard
Does endoscopic follow-up improve the outcome of patients with benign gastric ulcers and gastric cancer?
This study investigated whether an endoscopic surveillance program for patients with "benign" gastric ulcers and gastric cancer leads to early detection of neoplasms and improves survival. The clinical course of all patients diagnosed between 1977 and 1986 as having either gastric ulcers or gastric cancer was followed for a minimum of 3 years. Of 597 patients with initially benign gastric ulcers, 452 (76%) returned for the recommended endoscopic follow-up examinations. In eight patients (1.8%), repeated biopsies disclosed malignant neoplasms; four of these patients (0.9%) had become asymptomatic. Survival curves were nearly identical in patients who complied and those who did not. Of 241 pa…
Multiple Hypotheses Testing
The paper is mainly concerned with multiple testing procedures which control a given multiple level α. General concepts for this purpose are the closure test and a modification which is independent of the special structure of hypotheses and tests. We consider improvements of this modification using information about the logical dependences (redundancies) within the system of hypotheses and present an efficient algorithm. Finally, we discuss some problems which are specific for hierarchical systems of hypotheses, e.g. in model search.
Prospektive Beobachtungsstudie zur operativen Therapie des renalen Hyperparathyreoidismus
In einer prospektiven Beobachtungsstudie bei Patienten mit renalem Hyperparathyreoidismus wurden nach Eingriffen an den Nebenschilddrusen der Verlauf und die Abhangigkeit der Symptomatik von praoperativ ermittelten Laborparametern analysiert. Zwischen dem 1. 8. 1987 und dem 31. 12. 1995 wurden 79 Patienten operiert. Bei 72 Patienten erfolgten erstmalige Eingriffe an den Nebenschilddrusen. Bevorzugtes Operationsverfahren war die totale Parathyreoidektomie mit autologer Epithelkorperchenreplantation (n = 67). Informationen zum postoperativen Verlauf liegen von allen Patienten vor. Bei 74 der 79 Patienten erfolgten regelmasige Nachuntersuchungen (1–9, Median = 4) mit einer Nachbeobachtungszeit…
Global and multiple test procedures using ordered p-values—a review
This paper reviews global and multiple tests for the combination ofn hypotheses using the orderedp-values of then individual tests. In 1987, Rohmel and Streitberg presented a general method to construct global level α tests based on orderedp-values when there exists no prior knowledge regarding the joint distribution of the corresponding test statistics. In the case of independent test statistics, construction of global tests is available by means of recursive formulae presented by Bicher (1989), Kornatz (1994) and Finner and Roters (1994). Multiple test procedures can be developed by applying the closed test principle using these global tests as building blocks. Liu (1996) proposed represe…
Analysis of risk factors for restenosis after PTCA
To identify risk factors for restenosis, we evaluated data in 473 patients with single-vessel percutaneous transluminal coronary angioplasty (PTCA) and control angiography after 6 months. Restenosis, defined as (1) loss greater than 50% of the initial gain, and (2) stenosis greater than 50% was found in 138 patients (29.2%). Univariate analysis revealed eight factors related to restenosis: (1) duration of symptoms less than 1 month (P = 0.005), (2) unstable angina (P = 0.004), (3) high-grade stenosis before PTCA (P = 0.014), (4) large residual stenosis after PTCA (P = 0.001), (5) insufficient improvement of stenosis (P = 0.042), (6) prolonged single inflation time (P = 0.017), (7) prolonged…
Prospektive Evaluierung von Parathormongradienten (PTH-intakt) nach totaler Parathyreoidektomie und heterotoper Nebenschilddrüsenreplantation beim renalen Hyperparathyreoidismus
Grundlagen: In einer prospektiven Beobachtungsstudie nach totaler Parathyreoidektomie mit autologer Epithelkorperchenreplantation bei Patienten mit renalem Hyperparathyreoidismus wurden durch bilaterale Kubitalvenenblutentnahme ermittelte Parathormongradienten evaluiert.
Anorectal function and morphology in patients with sporadic proctalgia fugax
PURPOSE: The pathophysiology of sporadic proctalgia fugax remains unknown. This study investigates whether patients with this syndrome exhibit alterations in anal function and morphology. METHODS: Eighteen patients with sporadic proctalgia fugax and 18 sex-matched and age-matched healthy controls were studied. Manometric studies investigated anal resting and squeeze pressures, the rectoanal inhibitory reflex, rectal compliance, and smooth muscle response to edrophonium chloride administration. External and internal sphincter thickness was measured endosonographically. RESULTS: Patients had slightly higher (P=0.0291) anal resting pressures (65.5±11.4 mmHg) than controls (56±9.9 mmHg). Howeve…
Treatment of soft tissue sarcoma in childhood and adolescence: A report of the german cooperative soft tissue sarcoma study
Background In the first German soft tissue sarcoma (STS) study, CWS-81, 344 patients younger than 19 years of age who had previously untreated soft tissue sarcoma were studied. For this analysis, there were 218 patients with chemosensitive STS (Group A: rhabdomyosarcoma [RMS], synovial sarcoma, extraosseous Ewing sarcoma, leiomyosarcoma, undifferentiated sarcoma, and malignant peripheral neuroectodermal tumor) who could be studied for a minimum potential follow-up time of 6 years. Methods A staging system based on the postoperative extent of the disease was used. The chemotherapy for Stage I-III disease consisted of vincristine, dactinomycin, cyclophosphamide, and doxorubicin (VACA). Patien…