Data structures and algorithms for topological analysis
International audience; One of the steps of geometric modeling is to know the topology and/or the geometry of the objects considered. This paper presents different data structures and algorithms used in this study. We are particularly interested by algebraic structures, eg homotopy and homology groups, the Betti numbers, the Euler characteristic, or the Morse-Smale complex. We have to be able to compute these data structures, and for (homotopy and homology) groups, we also want to compute their generators. We are also interested in algorithms CIA and HIA presented in the thesis of Nicolas DELANOUE, which respectively compute the connected components and the homotopy type of a set defined by…
Unveiling Sex-Based Differences in the Effects of Alcohol Abuse: A Comprehensive Functional Meta-Analysis of Transcriptomic Studies
AbstractThe abuse of alcohol, one of the most popular psychoactive substances, can cause several pathological and psychological consequences, including alcohol use disorder (AUD). An impaired ability to stop or control alcohol intake despite adverse health or social consequences characterize AUD. While AUDs predominantly occur in men, growing evidence suggests the existence of distinct cognitive and biological consequences of alcohol dependence in women. The molecular and physiological mechanisms participating in these differential effects remain unknown. Transcriptomic technology permits the detection of the biological mechanisms responsible for such sex-based differences, which supports t…
Reference genome assessment from a population scale perspective: an accurate profile of variability and noise.
Abstract Motivation Current plant and animal genomic studies are often based on newly assembled genomes that have not been properly consolidated. In this scenario, misassembled regions can easily lead to false-positive findings. Despite quality control scores are included within genotyping protocols, they are usually employed to evaluate individual sample quality rather than reference sequence reliability. We propose a statistical model that combines quality control scores across samples in order to detect incongruent patterns at every genomic region. Our model is inherently robust since common artifact signals are expected to be shared between independent samples over misassembled regions …