0000000000009772
AUTHOR
Jhunlyn Lorenzo
Identification of Synaptic Integration Mode in CA3 Pyramidal Neuron Model
International audience; A morphologically realistic and anisotropic model of CA3 pyramidal neuron was developed to determine the synaptic integration modes the neuron is able to perform. Linearity and nonlinearity were identified in different synaptic locations with varying active mechanisms such as the presence of ionic channels in the dendritic arbor and the types of receptors in the synapse. Quantification of synaptic integration was performed using paired-pulse stimulation protocol and subthreshold input/output (sI/O) transformation. Results show that the mode of synaptic integration is location-dependent while the linearity or nonlinearity in the integration is mainly influenced by the…
Modeling of neuron-astrocyte interaction : application to signal and image processing
The introduction of the tripartite synapse and the discovery of calcium wave propagation motivated our research to explore the potential of astrocytes as active components in brain circuits. For decades, astrocytes have been considered passive cells whose primary function is metabolic and structural support to neurons; however, recent physiological measurements suggest that astrocytes modulate neural communication, strengthen synaptic efficacy, enhance synchronization, and promote homeostasis. Inspired by these biological functions, this research aimed to implement astrocytes in artificial spiking networks for deep learning applications. First, we modeled the biological interaction between …