Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly
15 páginas, 6 figuras, 1 tabla.
Structure-based analyses of Salmonella RcsB variants unravel new features of the Rcs regulon
18 páginas, 7 figuras, 2 tablas
Peptides as Versatile Platforms for Quantum Computing
The pursuit of novel functional building blocks for the emerging field of quantum computing is one of the most appealing topics in the context of quantum technologies. Herein we showcase the urgency of introducing peptides as versatile platforms for quantum computing. In particular, we focus on lanthanide-binding tags, originally developed for the study of protein structure. We use pulsed electronic paramagnetic resonance to demonstrate quantum coherent oscillations in both neodymium and gadolinium peptidic qubits. Calculations based on density functional theory followed by a ligand field analysis indicate the possibility of influencing the nature of the spin qubit states by means of contro…
Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis
9 p.-5 fig.
Conformational dynamism for DNA interaction in the Salmonella RcsB response regulator
17 páginas, 7 figuras, 1 tabla
Structural and Functional Characterization of Autophosphorylation in Bacterial Histidine Kinases
Autophosphorylation of histidine kinases (HK) is the first step for signal transduction in bacterial two-component signalling systems. As HKs dimerize, the His residue is phosphorylated in cis or trans depending on whether the ATP molecule used in the reaction is bound to the same or the neighboring subunit, respectively. The cis or trans autophosphorylation results from an alternative directionality in the connection between helices α1 and α2 in the HK DHp domain, in such a way that α2 could be oriented almost 90° counterclockwise or clockwise with respect to α1. Sequence and length variability of this connection appears to lie behind the different directionality and is implicated in partn…
The malate sensing two-component system MaeKR is a non-canonical class of sensory complex for C4-dicarboxylates
16 páginas, 7 figuras, 2 tablas
Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly. Corrigendum
The article by Casino et al. [IUCrJ (2018). 5, 765–779] is corrected.
Structural analysis and biochemical properties of laccase enzymes from two Pediococcus species
Summary Prokaryotic laccases are emergent biocatalysts. However, they have not been broadly found and characterized in bacterial organisms, especially in lactic acid bacteria. Recently, a prokaryotic laccase from the lactic acid bacterium Pediococcus acidilactici 5930, which can degrade biogenic amines, was discovered. Thus, our study aimed to shed light on laccases from lactic acid bacteria focusing on two Pediococcus laccases, P. acidilactici 5930 and Pediococcus pentosaceus 4816, which have provided valuable information on their biochemical activities on redox mediators and biogenic amines. Both laccases are able to oxidize canonical substrates as ABTS, ferrocyanide and 2,6‐DMP, and non‐…
Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases
13 páginas, 6 figuras, 3 tablas
Structural and functional role of Domain I for the insecticidal activity of the Vip3Aa protein from Bacillus thuringiensis
12 p.-4 fig.-2 tab.