0000000000011377

AUTHOR

Lilian Parra

showing 2 related works from this author

Alkylation of lithium dienediolates of butenoic acids. Regioselectivity effects of structure and leaving group of the alkylating agent

1998

Abstract Regioselectivity of alkylation of but-2-enoic acids 1 and 2 by alkyl halides strongly depends on the reactivity of the electrophile. High α selectivity results for saturated alkyl halides, whereas poor α-selectivity is obtained for highly reactive allyl and benzyl halides. For reactive alkylating halides selectivity is partly governed by the ion pairing aggregates of the dienediolates. Lithium bromide and the carboxylate generated in the ongoing reaction cause opposite effects on regioselectivity.

chemistry.chemical_classificationOrganic ChemistryLeaving groupRegioselectivityAlkylationBiochemistryMedicinal chemistrychemistry.chemical_compoundchemistryDrug DiscoveryElectrophileOrganic chemistrylipids (amino acids peptides and proteins)Reactivity (chemistry)CarboxylateSelectivityAlkylTetrahedron
researchProduct

ChemInform Abstract: Alkylation of Lithium Dienediolates of Butenoic Acids. Regioselectivity Effects of Structure and Leaving Group of the Alkylating…

2010

Abstract Regioselectivity of alkylation of but-2-enoic acids 1 and 2 by alkyl halides strongly depends on the reactivity of the electrophile. High α selectivity results for saturated alkyl halides, whereas poor α-selectivity is obtained for highly reactive allyl and benzyl halides. For reactive alkylating halides selectivity is partly governed by the ion pairing aggregates of the dienediolates. Lithium bromide and the carboxylate generated in the ongoing reaction cause opposite effects on regioselectivity.

chemistry.chemical_classificationChemistryLeaving groupRegioselectivityGeneral MedicineAlkylationMedicinal chemistrychemistry.chemical_compoundElectrophilelipids (amino acids peptides and proteins)Reactivity (chemistry)CarboxylateSelectivityAlkylChemInform
researchProduct