0000000000011447

AUTHOR

Claudio Sangregorio

0000-0002-2655-3901

showing 2 related works from this author

Cell uptake enhancement of folate targeted polymer coated magnetic nanoparticles.

2013

Dual targeted drug delivery systems represent a potential platform for developing efficient vector to tumor sites. In this study we evaluated a folate- and magnetic-targeted nanocarriers based on 10 nm iron oxide nanodomais coated with the properly synthesized and characterized folic acid (FA)-functionalized amphiphilic copolymer PHEA-PLA-PEG-FA. FA was chemically conjugated to one end of diamino-polyethylene glycol of 2000 Da, in order to ensure its exposition on the polymer coated magnetic nanoparticles (MNPs-FA). The prepared nanoparticles have been exhaustively characterized by different methods, including DLS, SEM, FT-IR and magnetic measurements. Magnetic nanoparticles showed dimensio…

IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; COPOLYMERSPolymersmedia_common.quotation_subjectBiomedical EngineeringPharmaceutical ScienceMedicine (miscellaneous)NanoparticleBioengineeringFolic AcidCoated Materials BiocompatibleCell Line TumorMaterials TestingHumansGeneral Materials ScienceViability assayMolecular Targeted TherapyInternalizationMagnetite Nanoparticlesmedia_commonChemistryNeoplasms Experimentalequipment and suppliesTreatment OutcomeTargeted drug deliveryCancer cellBiophysicsMCF-7 CellsMagnetic nanoparticlesNanocarriershuman activitiesFolate Targeting; Magnetic Nanoparticles; Cell Uptake; Ferrozine Assay; Polymer CoatingSuperparamagnetismJournal of biomedical nanotechnology
researchProduct

A novel dimer of oxo-di(acetato)-bridged manganese(III) dimers complex of potential biological significance

2000

[EN] Assembly of the tetranuclear oxomanganese(III) acetato cluster [Mn4O2(O2CMe)(7)(phen)(2)](BF4) from the dinuclear oxo-di(acetato)bridged manganese(III) species [Mn2O(O2CMe)(2)(H2O)(2)(phen)(2)](BF4)(2) . 3H(2)O in aqueous/acetic acid MeOH solution occurs via the new 'dimer of dimers' Mn-III complex [Mn2O(O2CMe)(3)(H2O)(phen)(2)](BF4) . MeOH possesing an unprecedent [Mn-4(mu-O)(2)(mu-O2Me)(4) (mu-(OH2O2CMe)-O-...)(2)] core.

ManganeseAqueous solutionStereochemistryCarboxylato complexesDimerchemistry.chemical_elementCrystal structureManganeseInorganic Chemistrychemistry.chemical_compoundAcetic acidN ligandsO ligandschemistryBiological significanceFISICA APLICADACrystal structuresMaterials ChemistryPhysical and Theoretical ChemistryCluster compounds
researchProduct