0000000000011978
AUTHOR
Jacques Bauer
showing 3 related works from this author
Cancer relapse under chemotherapy: why TLR2/4 receptor agonists can help.
2007
Liver or lung metastases usually relapse under chemotherapy. Such life-threatening condition urgently needs new, systemic anticancer compounds, with original and efficient mechanisms of action. In B16 melanoma mice treated with cyclophosphamide, D'Agostini et al. [D'Agostini, C., Pica, F., Febbraro, G., Grelli, S., Chiavaroli, C., Garaci, E., 2005. Antitumour effect of OM-174 and Cyclophosphamide on murine B16 melanoma in different experimental conditions. Int. Immunopharmacol. 5, 1205-1212.] recently found that OM-174, a chemically defined Toll-like receptor(TLR)2/4 agonist, reduces tumor progression and prolongs survival. Here we review 149 articles concerning molecular mechanisms of TLR2…
Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors.
2013
International audience; BACKGROUND: Lipids A, the lipophilic partial structure of lipopolysaccharides, induce regression of several tumor types in animal models. Rather than exerting direct cytotoxic effect, these compounds trigger the immune system which in turn stimulates secretion of cytokines, and activates the inducible nitric oxide synthase, as well as immune cell infiltration of tumors. OM-174 is an analogue of lipid A with dual action on toll-like receptors 2 and 4. In an experimental model of peritoneal carcinomatosis induced in BDIX rats by intraperitoneal injection of syngeneic PROb colon cancer cells, it induced a complete regression of tumors. The present phase I trial was cond…
Sur la structure, l'âge et l'origine des « brèches de Bosmendiette » (Pyrénées-Atlantiques)
2004
Resume Anterieurement attribuees a l'Albo-Aptien et considerees comme resultant du diapirisme des evaporites triasiques, les breches de Bosmendiette se seraient, pour certains auteurs recents, mises en place au Selandien (Paleocene), dans des canyons sous-marins etablis au sein d'un profond sillon, le long de la chaine des Pyrenees, du Roussillon jusqu'a l'Atlantique. Leur âge serait fonde sur la decouverte d'une riche microfaune pelagique de globigerinides. Nos recherches montrent qu'azoiques a leur base, pourvues de radiolaires et de rares foraminiferes benthiques au sommet, ces breches resultent en realite de la destruction de boucles de slumps affectant l'« Infralias ». Recouvertes en o…