0000000000014446

AUTHOR

Gernot Riedel

showing 4 related works from this author

Activation of phospholipases C and D by the novel metabotropic glutamate receptor agonist tADA.

1997

Abstract In hippocampal slices taken from 8-day-old rats, trans-azetidine-2,4-dicarboxylic acid (tADA), a novel glutamatergic agonist acting preferentially at class I mGluR receptors, activates phosphoinositide and phosphatidylcholine hydrolysis with widely different potencies. Inositol phosphate formation was maximally increased at 10 μM tADA ( ec 50: 1.2 μM), while phospholipase D activation was observed at a tADA concentration of 1 mM. This is the first report of a tADA-induced phospholipase D activity. © 1997 Elsevier Science Ltd. All rights reserved.

Agonistmedicine.drug_classInositol PhosphatesPhospholipaseBiologyIn Vitro TechniquesReceptors Metabotropic GlutamateHippocampusRats Sprague-DawleyCellular and Molecular NeurosciencemedicineExcitatory Amino Acid AgonistsPhospholipase DPhospholipase D activityAnimalsInositol phosphatePharmacologychemistry.chemical_classificationPhospholipase CPhospholipase DRatsEnzyme ActivationMetabotropic receptorBiochemistrychemistryMetabotropic glutamate receptorType C PhospholipasesAzetidinecarboxylic AcidNeuropharmacology
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Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives

2021

Contains fulltext : 239279.pdf (Publisher’s version ) (Open Access) The reproducibility crisis (or replication crisis) in biomedical research is a particularly existential and under-addressed issue in the field of behavioral neuroscience, where, in spite of efforts to standardize testing and assay protocols, several known and unknown sources of confounding environmental factors add to variance. Human interference is a major contributor to variability both within and across laboratories, as well as novelty-induced anxiety. Attempts to reduce human interference and to measure more "natural" behaviors in subjects has led to the development of automated home-cage monitoring systems. These syste…

Computer scienceCognitive NeuroscienceBiophysicsStress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13]Neurosciences. Biological psychiatry. NeuropsychiatryReviewBehavioral neurosciencecomputer.software_genreField (computer science)neuroscienceBehavioral NeurosciencePhenoTypervideo-trackingAll institutes and research themes of the Radboud University Medical CenterEthoVision XTBiotelemetryReplication crisisCognitionVariance (accounting)Cognitive artificial intelligenceData sciencehome-cageNeuropsychology and Physiological PsychologyScripting languageVideo trackingrodent behaviorcomputerRC321-571Frontiers in Behavioral Neuroscience
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The Forebrain of the Blind Cave Fish <i>Astyanax hubbsi </i>(Characidae)

1997

This paper presents a survey of the cell groups in the telencephalon of the teleost Astyanax hubbsi, based on series of transverse sections stained with the Nissl-, Kluver-Barrera and Bodian procedure

geographyAstyanax hubbsigeography.geographical_feature_categorybiologyAnatomybiology.organism_classificationCharacidaeBehavioral Neurosciencesymbols.namesakeDevelopmental NeuroscienceCaveForebrainNissl bodysymbolsFish <Actinopterygii>Brain, Behavior and Evolution
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Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals

2018

Objective Within the last years, there has been growing awareness of the negative repercussions of unstandardized planning, conduct and reporting of preclinical and biomedical research. Several initiatives have set the aim of increasing validity and reliability in reporting of studies and publications, and publishers have formed similar groups. Additionally, several groups of experts across the biomedical spectrum have published experience and opinion-based guidelines and guidance on potential standardized reporting. While all these guidelines cover reporting of experiments, an important step prior to this should be rigours planning and conduction of studies. The aim of this systematic revi…

0301 basic medicineprotocols & guidelinesData managementValiditylcsh:MedicineEnglish languageRigour03 medical and health sciences0302 clinical medicineEQIPD WP3 study groupProtocol1506030212 general & internal medicineInternal validitydrug evaluation preclinicalProtocol (science)Medical education630 Agriculturebusiness.industrylcsh:RGeneral MedicineBMJOS030104 developmental biologySystematic reviewPsychologybusinessInclusion (education)BMJ Open Science
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