0000000000017550

AUTHOR

Karin Danielsson

showing 3 related works from this author

Epstein-Barr virus is not detected in mucosal lichen planus

2018

Background Lichen planus (LP) is a chronic inflammatory, immunological, mucocutaneous disease can affect skin, genital and oral mucosa. Oral lichen planus (OLP) is the most common noninfectious, chronic inflammatory oral disease affecting 1-2% of the general adult population. World Health Organization (WHO) classifies OLP as a potentially malignant disorder. Epstein Barr virus or human herpesvirus-4, is a member of the herpes virus family and one of the most ubiquitous viruses known to human, infecting approximately 90% of the world’s adult population. The virus often infects B lymphocytes resulting in a wide spectrum of mucocutaneous and systemic diseases, ranging from mild lesions to aggr…

AdultMaleHerpesvirus 4 Humanmedicine.medical_specialtyMucocutaneous zonemedicine.disease_causeYoung Adult03 medical and health sciences0302 clinical medicinestomatognathic systemmedicineHumansSex organOral mucosaskin and connective tissue diseasesGeneral DentistryAgedAged 80 and overOral Medicine and PathologyMucous Membraneintegumentary systembusiness.industryResearchLichen Planusfood and beveragesMucous membrane030206 dentistryMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseEpstein–Barr virusDermatologystomatognathic diseasesmedicine.anatomical_structureOtorhinolaryngology030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASFemaleSurgeryOral lichen planusbusinessMedicina Oral Patología Oral y Cirugia Bucal
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Increased expression of p16 in both oral and genital lichen planus.

2018

Background Lichen Planus, LP, is an inflammatory disease of possible autoimmune origin affecting mainly oral and genital mucosa and skin. According to the WHO oral LP is considered a potentially malignant disorders. The p16 tumour suppressor protein can act as an inhibitor of cyclin dependent kinases 4 and 6 and thus down regulate cell cycle progression. Since the discovery of p16 several studies have evaluated its expression in various forms of human cancers. The aim of this study was to evaluate and compare the expression of p16 in oral and genital LP and corresponding healthy mucosa. Material and Methods A total of 76 cases of oral LP (OLP), 34 cases of genital LP (GLP), 12 cases of heal…

AdultMalemedicine.medical_specialtyDisease03 medical and health sciences0302 clinical medicinestomatognathic systemMedicineHumansSex organskin and connective tissue diseasesGeneral DentistryCyclin-Dependent Kinase Inhibitor p16AgedAged 80 and overOral Medicine and Pathologyintegumentary systembusiness.industryResearchLichen Planus030206 dentistryMiddle Aged:CIENCIAS MÉDICAS [UNESCO]Dermatologystomatognathic diseasesOtorhinolaryngology030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASSurgeryFemaleGenital Diseases MalebusinessGenital Diseases FemaleGenital lichen planusLichen Planus OralMedicina oral, patologia oral y cirugia bucal
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Difficulties detecting miRNA-203 in human whole saliva by the use of PCR

2014

Objectives: Oral Lichen Planus (OLP) is a chronic disease of the oral mucosa, and according to the WHO also a pre malignant condition. Micro-RNAs are short non coding RNAs capable of regulating mRNA expression. MiRNA:scan be detected in tissue, blood and human whole saliva (HWS) and recently we have shown miR-203 to be up-regulated in tissue from OLP lesions. Study Design: In order to see whether mRNA as well as miR-203 could be detected also in HWS, saliva from healthy controls and patients with OLP were analysed using two different PCR methods. Results: Results showed low mRNA and miRNA levels in general in HWS samples, making it hard to generate conclusive results. Conclusions: In order …

SalivaPathologymedicine.medical_specialtyOdontologíaPolymerase Chain Reactionlaw.inventionstomatognathic systemlawmicroRNAHumansMedicineWhole salivaOral mucosaSalivaGeneral DentistryPolymerase chain reactionMessenger RNAOral Medicine and Pathologybusiness.industryResearchRNA:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseCiencias de la saludMicroRNAsstomatognathic diseasesmedicine.anatomical_structureOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASImmunologySurgeryOral lichen planusbusinessLichen Planus OralMedicina Oral Patología Oral y Cirugia Bucal
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