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RESEARCH PRODUCT

Epstein-Barr virus is not detected in mucosal lichen planus

Karin DanielssonMajid EbrahimiElisabet NylanderMats Sjöström

subject

AdultMaleHerpesvirus 4 Humanmedicine.medical_specialtyMucocutaneous zonemedicine.disease_causeYoung Adult03 medical and health sciences0302 clinical medicinestomatognathic systemmedicineHumansSex organOral mucosaskin and connective tissue diseasesGeneral DentistryAgedAged 80 and overOral Medicine and PathologyMucous Membraneintegumentary systembusiness.industryResearchLichen Planusfood and beveragesMucous membrane030206 dentistryMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseEpstein–Barr virusDermatologystomatognathic diseasesmedicine.anatomical_structureOtorhinolaryngology030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASFemaleSurgeryOral lichen planusbusiness

description

Background Lichen planus (LP) is a chronic inflammatory, immunological, mucocutaneous disease can affect skin, genital and oral mucosa. Oral lichen planus (OLP) is the most common noninfectious, chronic inflammatory oral disease affecting 1-2% of the general adult population. World Health Organization (WHO) classifies OLP as a potentially malignant disorder. Epstein Barr virus or human herpesvirus-4, is a member of the herpes virus family and one of the most ubiquitous viruses known to human, infecting approximately 90% of the world’s adult population. The virus often infects B lymphocytes resulting in a wide spectrum of mucocutaneous and systemic diseases, ranging from mild lesions to aggressive malignancies. The aim of this study was to investigate expression of the EBV encoded RNAs EBER1 and EBER2 in oral and genital lichen planus and compare results with normal tissues in situ hybridization which is considered the golden standard for detection of EBER. Material and Methods A total of 68 biopsies, 25 oral LP, 26 genital LP, 10 oral controls and finally 7 genital controls were analysed using situ hybridization. Results All samples had RNA as shown by the control slide, whereas no case contained neither EBER1 nor EBER2. Conclusions Based on results from our study EBV is not involved in aetiology of lichen planus. Key words:Mucosal lichen planus, Epstein - Barr virus.

yearjournalcountryeditionlanguage
2018-09-01Medicina Oral Patología Oral y Cirugia Bucal
https://doi.org/10.4317/medoral.22617