0000000000017867

AUTHOR

Isabel Alonso-muriel

showing 3 related works from this author

Plasma levels of soluble vascular endothelial growth factor receptor-1 may determine the onset of early and late ovarian hyperstimulation syndrome

2006

BACKGROUND Ovarian hyperstimulation syndrome (OHSS) is a life-threatening condition associated with ovarian stimulation. Its pathophysiology is unknown and its treatment continues to be empirical. Early (E)- and late (L)-OHSS occur in women at risk, though not in all cases. Vascular endothelial growth factor (VEGF) is related to increased vascular permeability in OHSS. We analysed the dynamics of the VEGF system in E- and L-OHSS. METHODS A prospective cohort of women undergoing IVF-ICSI treatment were divided into groups. E-OHSS: Nonpregnant patients classified as women not at risk (group 1) (n = 11) and patients at risk who did not (group 2) (n = 18) and did (group 3) (n = 8) develop sever…

AdultOvulationVascular Endothelial Growth Factor Amedicine.medical_specialtyTime Factorsmedia_common.quotation_subjectOvarian hyperstimulation syndromeVascular permeabilityOvaryFertilization in VitroBiologyCohort StudiesOvarian Hyperstimulation Syndromechemistry.chemical_compoundInternal medicineBlood plasmamedicineHumansalpha-MacroglobulinsSperm Injections IntracytoplasmicProspective cohort studyOvulationmedia_commonVascular Endothelial Growth Factor Receptor-1OvaryRehabilitationObstetrics and Gynecologymedicine.diseaseVascular endothelial growth factorEndocrinologymedicine.anatomical_structureReproductive MedicinechemistryOocytesFemaleSoluble fms-like tyrosine kinase-1Human Reproduction
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Low-dose dopamine agonist administration blocks vascular endothelial growth factor (VEGF)-mediated vascular hyperpermeability without altering VEGF r…

2006

No specific treatment is available for ovarian hyperstimulation syndrome (OHSS), the most important complication in infertile women treated with gonadotropins. OHSS is caused by increased vascular permeability (VP) through ovarian hypersecretion of vascular endothelial growth factor (VEGF)activating VEGF receptor 2 (VEGFR-2). We previously demonstrated in an OHSS rodent model that increased VP was prevented by inactivating VEGFR-2 with a receptor antagonist(SU5416).However,duetoitstoxicity(thromboembolism) and disruption of VEGFR-2-dependent angiogenic processes critical for pregnancy, this kind of compound cannot be used clinically to prevent OHSS. Dopamine receptor 2 (Dp-r2) agonists, use…

AgonistVascular Endothelial Growth Factor Amedicine.medical_specialtyCabergolinemedicine.drug_classAngiogenesisOvarian hyperstimulation syndromeNeovascularization PhysiologicBiologyDopamine agonistCapillary Permeabilitychemistry.chemical_compoundOvarian Hyperstimulation SyndromeEndocrinologyCorpus LuteumInternal medicineCabergolinemedicineAnimalsRNA MessengerErgolinesPhosphorylationRats WistarReceptors Dopamine D2Kinase insert domain receptorReceptor antagonistmedicine.diseaseVascular Endothelial Growth Factor Receptor-2RatsVascular endothelial growth factorDisease Models AnimalEndocrinologychemistryDopamine AgonistsFemalemedicine.drugEndocrinology
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Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women und…

2007

Background Ovarian hyperstimulation syndrome (OHSS) is a result of ovarian overexpression of vascular endothelial growth factor (VEGF) and its receptor 2 (VEGFR2). VEGF/VEGFR2 binding disrupts cellular junctions and increases vascular permeability (VP), a characteristic of OHSS, but enhances angiogenesis, which is a fundamental step in implantation. In animals, the dopamine agonist Cabergoline (Cb2) prevents VP without affecting angiogenesis. In humans, Cb2 averts OHSS, but a possible detrimental effect on angiogenesis and implantation has not been explored. A pilot study was designed to analyze whether or not Cb2 administration, as a procedure for preventing OHSS, affects the outcome of as…

Adultmedicine.medical_specialtyCabergolinePregnancy RateReproductive Techniques AssistedOvarian hyperstimulation syndromePilot ProjectsBiologyDopamine agonistAndrologyOvarian Hyperstimulation Syndromechemistry.chemical_compoundPregnancyCabergolineInternal medicinemedicineHumansEmbryo ImplantationErgolinesOvarian follicleRetrospective StudiesPregnancyRehabilitationObstetrics and Gynecologymedicine.diseaseVascular endothelial growth factorPregnancy ratemedicine.anatomical_structureEndocrinologyReproductive MedicinechemistryDopamine AgonistsGestationFemalemedicine.drugHuman Reproduction
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