0000000000018640

AUTHOR

Hans-joachim Kuss

showing 3 related works from this author

Therapeutic drug monitoring of tricyclic antidepressants: how does it work under clinical conditions?

2003

Therapeutic drug monitoring (TDM) of tricyclic antidepressants (TCA) is established in the treatment of depression to optimize outcome and safety. However, there are few reports on TDM under naturalistic clinical conditions. In the present study, we investigated a TDM group (TDM) and a randomly assigned parallel group without TDM (no-TDM) while on TCA treatment. Serum levels were analyzed in both cohorts, but feedback and dose recommendation were only provided for the TDM group. Serum levels of TCA were assessed by high-performance liquid chromatography (HPLC). The outcome was measured weekly using the Hamilton Depression Rating Scale (HAMD), the Clinical Global Impressions Scale (CGI), and…

Malemedicine.medical_specialtyAmitriptylinePharmacologyAntidepressive Agents Tricycliclaw.inventionTherapeutic indexRandomized controlled triallawInternal medicineHamdMedicineHumansPharmacology (medical)Amitriptylinechemistry.chemical_classificationPsychiatric Status Rating ScalesDepressive Disordermedicine.diagnostic_testbusiness.industryGeneral MedicineMiddle AgedDoxepinClinical trialPsychiatry and Mental healthTreatment OutcomechemistryTherapeutic drug monitoringFemaleDoxepinDrug Monitoringbusinessmedicine.drugTricyclicPharmacopsychiatry
researchProduct

SPCCTDM, a Catalogue for Analysis of Therapeutic Drug Monitoring Related Contents

2013

Therapeutic drug monitoring (TDM) has consistently been shown to be useful for optimization of drug therapy. For the first time, a method has been developed for the text analysis of TDM in SPCs in that a catalogue SPC-ContentTDM (SPCCTDM) provides a codification of the content of TDM in SPCs. It consists of six structure-related items (dose, adverse drug reactions, drug interactions, overdose, pregnancy/breast feeding, and pharmacokinetics) according to implicit or explicit references to TDM in paragraphs of the SPC, and four theory-guided items according to the information about ranges of plasma concentrations and a recommendation of TDM in the SPC. The catalogue is regarded as valid for t…

medicine.medical_specialtymedicine.diagnostic_testTherapeutic drug monitoringbusiness.industrymedicineIntensive care medicinebusiness
researchProduct

SPCCTDM, a Catalogue for Analysis of Therapeutic Drug Monitoring Related Contents in the Drug Prescription Information

2010

Therapeutic drug monitoring (TDM) has consistently been shown to be useful for optimization of drug therapy. For the first time, a method has been developed for the text analysis of TDM in SPCs in that a catalogue SPC-ContentTDM (SPCCTDM) provides a codification of the content of TDM in SPCs. It consists of six structure-related items (dose, adverse drug reactions, drug interactions, overdose, pregnancy/breast feeding, and pharmacokinetics) according to implicit or explicit references to TDM in paragraphs of the SPC, and four theory-guided items according to the information about ranges of plasma concentrations and a recommendation of TDM in the SPC. The catalogue is regarded as valid for t…

Drugmedicine.medical_specialtymedicine.diagnostic_testbusiness.industrymedia_common.quotation_subjectcomputer.software_genreTherapeutic drug monitoringPlasma concentrationmedicineMedical physicsData miningDrug reactionMedical prescriptionbusinesscomputerBreast feedingmedia_commonInternational Journal of Knowledge Discovery in Bioinformatics
researchProduct