0000000000019383

AUTHOR

Marlies Wagner

showing 4 related works from this author

Multimodal quantitative MRI assessment of cortical damage in relapsing-remitting multiple sclerosis

2016

Purpose To investigate magnetization transfer ratio (MTR), T1 relaxation time, and proton density (PD) as indicators of gray matter damage in relapsing-remitting multiple sclerosis (RRMS), reflecting different aspects of microstructural damage and as imaging correlates of clinical disability. We aimed to determine which of these parameters may optimally quantify cortical damage, and serve as an imaging surrogate of clinical disability. In this study, cortical values of MTR, a surrogate for demyelination in MS, of PD, reflecting replacement of neural tissue by water, and of T1 , indicating a complex array of microstructural changes, were assessed in a group of RRMS patients in comparison to …

Pathologymedicine.medical_specialtyExpanded Disability Status Scalemedicine.diagnostic_testbusiness.industryMultiple sclerosisArea under the curveMagnetic resonance imagingmedicine.disease030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicinemedicine.anatomical_structureRelapsing remittingCerebral cortexmedicineRadiology Nuclear Medicine and imagingMagnetization transferNuclear medicinebusinessProton density030217 neurology & neurosurgeryJournal of Magnetic Resonance Imaging
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Flat Panel Computed Tomography Pooled Blood Volume and Infarct Prediction in Endovascular Stroke Treatment

2019

Background and Purpose— Patients with large-vessel stroke frequently need to be transferred to comprehensive stroke centers for endovascular treatment. An update of physiological perfusion parameters and stroke progression on arrival is desirable. We examined the reliability of preinterventional pooled blood volume (PBV)-maps acquired by flat-panel detector computed tomography (CT) in the interventional angiography suite. Methods— The volumes of preinterventional perfusion deficit in flat-panel detector CT-PBV source images were compared with final infarct volume on follow-up multislice-CT after endovascular treatment of 29 consecutive patients with occlusion of the middle cerebral artery …

Brain InfarctionMaleMechanical Thrombolysismedicine.medical_treatmentBlood volume030204 cardiovascular system & hematology03 medical and health sciencesPostoperative Complications0302 clinical medicinePredictive Value of Testsmedicine.arteryOcclusionmedicineCerebral Blood VolumeHumanscardiovascular diseasesStrokeAgedAdvanced and Specialized Nursingmedicine.diagnostic_testbusiness.industryCerebral infarctionEndovascular ProceduresThrombolysisMiddle Agedmedicine.diseaseCerebral AngiographyStrokeMiddle cerebral arteryAngiographyFemaleNeurology (clinical)Internal carotid arteryTomography X-Ray ComputedCardiology and Cardiovascular MedicinebusinessNuclear medicine030217 neurology & neurosurgeryFollow-Up StudiesStroke
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The Relationship between Gray Matter Quantitative MRI and Disability in Secondary Progressive Multiple Sclerosis

2016

Purpose: In secondary progressive Multiple Sclerosis (SPMS), global neurodegeneration as a driver of disability gains importance in comparison to focal inflammatory processes. However, clinical MRI does not visualize changes of tissue composition outside MS lesions. This quantitative MRI (qMRI) study investigated cortical and deep gray matter (GM) proton density (PD) values and T1 relaxation times to explore their potential to assess neuronal damage and its relationship to clinical disability in SPMS. Materials and Methods: 11 SPMS patients underwent quantitative T1 and PD mapping. Parameter values across the cerebral cortex and deep GM structures were compared with 11 healthy controls, and…

Central Nervous SystemMalePathologyPhysiologylcsh:MedicinePathology and Laboratory MedicineNervous SystemBrain mappingDiagnostic Radiology030218 nuclear medicine & medical imaging0302 clinical medicineThalamusMedicine and Health SciencesRelaxation TimeMedicineGray Matterlcsh:ScienceCerebrospinal FluidCerebral CortexMultidisciplinarymedicine.diagnostic_testRadiology and ImagingPhysicsPutamenNeurodegenerationBrainNeurodegenerative DiseasesMultiple Sclerosis Chronic ProgressiveMagnetic Resonance ImagingBody Fluidsmedicine.anatomical_structureNeurologyCerebral cortexPhysical SciencesFemaleAnatomyResearch ArticleAdultmedicine.medical_specialtyMultiple SclerosisImaging TechniquesImmunologyCentral nervous systemThalamusResearch and Analysis MethodsAutoimmune Diseases03 medical and health sciencesSigns and SymptomsDiagnostic MedicineIntellectual DisabilityHumansddc:610Relaxation (Physics)business.industryMultiple sclerosislcsh:RBiology and Life SciencesMagnetic resonance imagingmedicine.diseaseDemyelinating DisordersCase-Control StudiesLesionslcsh:QClinical ImmunologyClinical Medicinebusiness030217 neurology & neurosurgeryPLOS ONE
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A Paravermal Trans-Cerebellar Approach to the Posterior Fossa Tumor Causes Hypertrophic Olivary Degeneration by Dentate Nucleus Injury

2021

Background: In brain tumor surgery, injury to cerebellar connectivity pathways can induce a neurodegenerative disease called hypertrophic olivary degeneration (HOD), along with a disabling clinical syndrome. In children, cerebellar mutism syndrome (CMS) is another consequence of damage to cerebello&ndash

EpendymomaCancer Researchmedicine.medical_specialtyCerebellumcerebellumPosterior fossamedulloblastomalcsh:RC254-282ArticleHOD03 medical and health sciences0302 clinical medicineMedicineneurosurgeryMedulloblastomaPilocytic astrocytomabusiness.industryCMSOlivary degenerationmedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.anatomical_structureDentate nucleusOncology030220 oncology & carcinogenesisRadiologyNeurosurgerybusiness030217 neurology & neurosurgerycerebellar mutismCancers
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