0000000000021772

AUTHOR

I. Jaunalksne

showing 3 related works from this author

Tumour necrosis factor   in rheumatoid arthritis and osteoarthritis patients in blood serum and synovial fluid

2010

Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown cause which affects the ability of elderly people to work. There is strong evidence to suggest that inflammatory mediators such as tumour necrosis factor α (TNFα) and interleukin 1 (IL1) have a critical role in the pathogenesis of RA. Biological treatment blocks pathological pathways in the actions of these proinflammatory cytokines. The aim of this study was …

musculoskeletal diseasesAutoimmune diseasebusiness.industryImmunologyInterleukinmedicine.diseaseGeneral Biochemistry Genetics and Molecular BiologyProinflammatory cytokinePathogenesisBlood serumRheumatologyRheumatoid arthritisImmunologymedicineImmunology and AllergySynovial fluidTumor necrosis factor alphabusinessAnnals of the Rheumatic Diseases
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Analysis of the Immune Status in Latvian Chernobyl Clean-up Workers with Nononcological Thyroid Diseases

2001

The aim of the present work was to characterize the immune status of 385 individuals who participated in the 1986–90 clean-up work of the after effects of the Chernobyl nuclear power plant explosion. Fifty-nine Chernobyl clean-up workers developed the most common thyroid diseases; euthyroid nodular and diffuse goiter; 47 healthy blood donors were taken as controls. The levels of immunoglobulins (IgA, IgG and IgM), the numbers of peripheral blood leukocytes, lymphocytes, monocytes, T lymphocytes and their subpopulations (CD3+, CD4+, CD8+), B lymphocytes (CD19+), natural killer (NK) cells (CD16+), classical and alternative pathway activity of complement (CH50, APH50), the C3 split product C3d…

endocrine systemmedicine.medical_specialtyGoiterbiologybusiness.industryImmunologyThyroidGeneral MedicineCD16medicine.diseasemedicine.anatomical_structureEndocrinologyImmune systemInternal medicineImmunologyAlternative complement pathwaybiology.proteinMedicineEuthyroidAntibodybusinessCD8Scandinavian Journal of Immunology
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Cerebrospinal fluid T-regulatory cells recognize Borrelia burgdorferi NAPA in chronic Lyme borreliosis.

2013

The NapA protein of B. burgdorferi is essential for the persistence of spirochetes in ticks. One of the most intriguing aspects of NapA is its potential to interfere with the host immune system. Here, we investigated the role of the acquired immune responses induced by NapA in the cerebrospinal fluids (CSF) of patients with chronic Lyme borreliosis. We evaluated the cytokine profile induced in microglia cells and CSF T cells following NapA stimulation. We report here that NapA induced a regulatory T (Treg) response in the CSF of patients with chronic Lyme borreliosis and it is able to expand this suppressive response by promoting the production of TGF-β and IL-10 by microglia cells. Collect…

AdultMaleT regChemokineT-LymphocytesT cells; T reg; Borrelia; Lyme; Adult; Bacterial Proteins; Cerebrospinal Fluid; Chemokines CXC; Chronic Disease; Female; Humans; Interleukin-10; Lyme Disease; Male; Microglia; Middle Aged; T-Lymphocytes Regulatory; Transforming Growth Factor betaImmunologyT cellsT-Lymphocytes RegulatoryImmune systemLyme diseaseBacterial ProteinsTransforming Growth Factor betaImmunology and AllergyMedicineHumansBorrelia burgdorferiCerebrospinal FluidPharmacologyNAPACXCLyme DiseasebiologyMicrogliabusiness.industryBorreliaTransforming growth factor betaMiddle Agedbiology.organism_classificationmedicine.diseaseRegulatoryInterleukin-10Interleukin 10medicine.anatomical_structureImmunologyChronic Diseasebiology.proteinLymeFemaleMicrogliaChemokinesbusinessChemokines CXC
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