An extended reconstruction of human gut microbiota metabolism for personalized nutrition

ABSTRACTUnderstanding how diet and gut microbiota interact in the context of human health is a key question in personalized nutrition. Genome-scale metabolic networks and constraint-based modeling approaches are promising to systematically address this complex question. However, when applied to nutritional questions, a major issue in existing reconstructions is the lack of information about degradation pathways of relevant nutrients in the diet that are metabolized by the gut microbiota. Here, we present AGREDA, an extended reconstruction of the human gut microbiota metabolism for personalized nutrition. AGREDA includes the degradation pathways of 231 nutrients present in the human diet and…