0000000000022319

AUTHOR

Ludger Grote

showing 32 related works from this author

Recommendations for the management of patients with obstructive sleep apnoea and hypertension.

2013

This article is aimed at addressing the current state-of-the-art in epidemiology, pathophysiology, diagnostic procedures and treatment options for appropriate management of obstructive sleep apnoea (OSA) in cardiovascular (in particular hypertensive) patients, as well as for the management of cardiovascular diseases (in particular arterial hypertension) in OSA patients. The present document is the result of work performed by a panel of experts participating in the European Union COST (Cooperation in Scientific and Technological research) Action B26 on OSA, with the endorsement of the European Respiratory Society and the European Society of Hypertension. In particular, these recommendations …

Pulmonary and Respiratory MedicineAdultMalemedicine.medical_specialtySleep apnoea COSTMEDLINEArterial hypertension continuous positive airway pressure treatment guidelines hypertension treatment obstructive sleep apnoeaCardiologyMyocardial IschemiaBlood PressureSettore MED/10 - Malattie Dell'Apparato Respiratoriota3111Renin-Angiotensin SystemRisk FactorsEpidemiologymedicinemedia_common.cataloged_instanceHumansIn patientObesityEuropean unionIntensive care medicineStrokeLife StyleSocieties Medicalmedia_commonAgedta3126InflammationSleep Apnea Obstructivebusiness.industryRespirationSleep apneaMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREMiddle Agedmedicine.diseaseObesityEuropeStrokeBlood pressureHypertensionFemaleEndothelium VascularbusinessThe European respiratory journal
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Mild obstructive sleep apnea increases hypertension risk, challenging traditional severity classification

2020

STUDY OBJECTIVES: The association of mild obstructive sleep apnea (OSA) with important clinical outcomes remains unclear. We aimed to investigate the association between mild OSA and systemic arterial hypertension (SAH) in the European Sleep Apnea Database cohort. METHODS: In a multicenter sample of 4,732 participants, we analyzed the risk of mild OSA (subclassified into 2 groups: mild(AHI 5-<11/h) (apnea-hypopnea index [AHI], 5 to <11 events/h) and mild(AHI 11-<15/h) (AHI, ≥11 to <15 events/h) compared with nonapneic snorers for prevalent SAH after adjustment for relevant confounding factors including sex, age, smoking, obesity, daytime sleepiness, dyslipidemia, chronic obstructive pulmona…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyEuropean Sleep Apnea Database Mild obstructive sleep apnea Systemic arterial hypertensionPolysomnographyDisorders of Excessive SomnolenceSettore MED/10 - Malattie Dell'Apparato RespiratorioHypertension risk03 medical and health sciences0302 clinical medicinestomatognathic systemRisk FactorsInternal medicinesystemic arterial hypertensionmedicineHumansEuropean Sleep Apnea DatabaseSleep Apnea ObstructiveSystemic arterial hypertensionbusiness.industrymedicine.diseaseScientific InvestigationsClinical neurologyrespiratory tract diseasesnervous system diseasesObstructive sleep apneamild obstructive sleep apneaDiabetes Mellitus Type 2NeurologyHypertensionNeurology (clinical)Human medicinebusiness030217 neurology & neurosurgery
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Clinical presentation of patients with suspected obstructive sleep apnea and self-reported physician-diagnosed asthma in the ESADA cohort.

2018

Obstructive sleep apnea (OSA) and asthma are often associated and several studies suggest a bidirectional relationship between asthma and OSA. This study analyzed the characteristics of patients with suspected OSA from the European Sleep Apnea Database according to presence/absence of physician-diagnosed asthma. Cross-sectional data in 16,236 patients (29.1% female) referred for suspected OSA were analyzed according to occurrence of physician-diagnosed asthma for anthropometrics, OSA severity and sleepiness. Sleep structure was assessed in patients studied by polysomnography (i.e. 48% of the sample). The prevalence of physician-diagnosed asthma in the entire cohort was 4.8% (7.9% in women, …

AdultMaleobesitymedicine.medical_specialtyCognitive NeurosciencePolysomnographyPopulationPolysomnographySettore MED/10 - Malattie Dell'Apparato Respiratoriota3111Cohort Studies03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineobstructive sleep apnea ; asthma ; ESADA cohortInternal medicineEpidemiologygenderMedicineHumansProspective StudieseducationPhysician's RoleAsthmaAgededucation.field_of_studySleep Apnea Obstructivemedicine.diagnostic_testbusiness.industryta1184sleep-disordered breathingSleep apneaGeneral MedicineMiddle Agedmedicine.diseaseObesityAsthmarespiratory tract diseasesObstructive sleep apneaEuropeCross-Sectional Studies030228 respiratory systemCohortepidemiologyFemaleSelf Reportbusiness030217 neurology & neurosurgeryJournal of sleep research
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Positive Airway Pressure Treatment Reduces Glycated Hemoglobin (HbA1c) Levels in Obstructive Sleep Apnea Patients: Longitudinal Data from the Esada

2019

European-Respiratory-Society (ERS) International Congress -- SEP 28-OCT 02, 2019 -- Madrid, SPAIN

medicine.medical_specialtyLongitudinal dataGastroenterologyComorbidities03 medical and health sciencesHba1c levelchemistry.chemical_compound0302 clinical medicineDiabetes mellitusInternal medicinePositive airway pressuremedicine030212 general & internal medicinebusiness.industryType 2 Diabetes MellitusSleep apneaSystemic effectmedicine.diseaserespiratory tract diseasesObstructive sleep apnea030228 respiratory systemApnea–hypopnea indexchemistryCardiologyGlycated hemoglobinbusinessBody mass indexTurkish Thoracic Journal
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Sleep laboratories reopening and COVID-19 : a European perspective

2021

The clinical activities regarding sleep disordered breathing (SDB) have been sharply interrupted during the initial phase of the COVID-19 epidemic throughout Europe. In the last months, activities have gradually restarted, according to epidemiological phase of COVID-19 and National recommendations. The recent increase in cases throughout Europe obliges to reconsider management strategies of SDB accordingly. Diagnosis of SDB and initiation of treatment pose some specific problems to be addressed to preserve safety of the patients and health personnel. This perspective document by a group of European sleep experts aims at summarising some different approaches followed in Europe and United Sta…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyTelemedicineMEDLINESettore MED/10 - Malattie Dell'Apparato Respiratoriohealth personnelPhase (combat)Sleep medicine03 medical and health sciences0302 clinical medicineSleep Apnea SyndromesEpidemiologyPositive airway pressuremedicinePulmonary MedicineHumansIntensive care medicinebusiness.industrySafety precautionPerspective (graphical)COVID-19[SDV] Life Sciences [q-bio]Europe030228 respiratory systemPerspectiveSleep (system call)patienttelemedicineHuman medicinebusinessLaboratories030217 neurology & neurosurgeryThe European respiratory journal
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Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea : data from t…

2020

Background and aim: Obstructive sleep apnea (OSA) is an independent risk factor for dyslipidemia. The current study examined the effects of positive airway pressure (PAP) treatment on lipid status in the European Sleep Apnea Database (ESADA). Methods: The prospective cohort study enrolled 1564 OSA subjects (74% male, mean age 54 ± 11y, body mass index (BMI) 32.7 ± 6.6 kg/m2 and apnea-hypopnea index (AHI) 40.3 ± 24.4 n/h) undergoing PAP therapy for at least three months (mean 377.6 ± 419.5 days). Baseline and follow-up total cholesterol (TC) from nine centers were analyzed. Repeated measures and logistic regression tests (adjusted for age, sex, weight changes, lipid lowering medication, PAP …

cardiovascular riskAdultMalemedicine.medical_specialtySettore MED/10 - Malattie Dell'Apparato RespiratorioPositive airway pressure03 medical and health sciences0302 clinical medicineInternal medicinePositive airway pressuremedicineCardiovascular risk Cholesterol Hypoxia Sleep apneaHumanspositive airway pressureProspective StudiesRisk factorProspective cohort studyHypoxiaAgedSleep Apnea ObstructiveFramingham Risk ScoreContinuous Positive Airway Pressurebusiness.industryhypoxiaSleep apneaSleep apneacholesterolGeneral MedicineMiddle Agedmedicine.diseasesleep apneaCardiovascular riskObstructive sleep apneaCardiovascular risk ; Cholesterol ; Hypoxia ; Positive airway pressure ; Sleep apnea.Cholesterol030228 respiratory systemPatient ComplianceFemaleHuman medicinebusinessBody mass index030217 neurology & neurosurgeryDyslipidemiaSleep medicine
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Variability in recording and scoring of respiratory events during sleep in Europe: a need for uniform standards.

2015

Abstract: Uniform standards for the recording and scoring of respiratory events during sleep are lacking in Europe, although many centres follow the published recommendations of the American Academy of Sleep Medicine. The aim of this study was to assess the practice for the diagnosis of sleep-disordered breathing throughout Europe. A specially developed questionnaire was sent to representatives of the 31 national sleep societies in the Assembly of National Sleep Societies of the European Sleep Research Society, and a total of 29 countries completed the questionnaire. Polysomnography was considered the primary diagnostic method for sleep apnea diagnosis in 10 (34.5%), whereas polygraphy was …

medicine.medical_specialtyPediatricsCognitive NeurosciencePolysomnographyAlternative medicinePolysomnographySleep medicine03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineSleep Apnea SyndromesSurveys and QuestionnairesmedicineHumansSocieties MedicalSleep Medicine Specialtymedicine.diagnostic_testbusiness.industryRespirationApneaSleep apneaGeneral Medicinemedicine.diseaseObstructive sleep apneaEurope030228 respiratory systemFamily medicineHuman medicineSleep (system call)medicine.symptombusinessSleepHypopnea030217 neurology & neurosurgeryJournal of sleep research
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Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA coho…

2018

The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1, 415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m2, apnea–hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analyse…

Data AnalysisMaleTime FactorsExcessive daytime sleepinessWeight Gainexcessive daytime sleepineBody Mass IndexCohort StudiesBehavioral Neuroscience0302 clinical medicinePositive airway pressureMedicineLongitudinal StudiesProspective Studiesobstructive sleep apneaSleep Apnea ObstructiveContinuous Positive Airway PressureEpworth Sleepiness ScaleSleep apneaGeneral MedicineMiddle Agedweight ; central obesity ; positive airway pressure ; obstructive sleep apnea ; ESADA cohortEuropeObesity AbdominalCardiologyFemaleWaist Circumferencemedicine.symptomAdultmedicine.medical_specialtyCognitive NeuroscienceSettore MED/10 - Malattie Dell'Apparato Respiratorio03 medical and health sciencesInternal medicineHumanspositive airway pressureAgedcentral obesitybusiness.industryBody Weightbody weight central obesity excessive daytime sleepiness obstructive sleep apnea positive airway pressureta3121medicine.diseaseObesityrespiratory tract diseasesObstructive sleep apnea030228 respiratory systemHuman medicinebusinessBody mass indexWeight gain030217 neurology & neurosurgery
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Clusters of sleep apnoea phenotypes: A large pan-European study from the European Sleep Apnoea Database (ESADA)

2021

Background and objective: To personalize OSA management, several studies have attempted to better capture disease heterogeneity by clustering methods. The aim of this study was to conduct a cluster analysis of 23 000 OSA patients at diagnosis using the multinational ESADA. Methods: Data from 34 centres contributing to ESADA were used. An LCA was applied to identify OSA phenotypes in this European population representing broad geographical variations. Many variables, including symptoms, comorbidities and polysomnographic data, were included. Prescribed medications were classified according to the ATC classification and this information was used for comorbidity confirmation. Results: Eight cl…

MalePulmonary and Respiratory MedicineDatabases FactualTreatment adherenceinternational databaseComorbidityDiseasecomputer.software_genre03 medical and health sciencesSleep Apnea Syndromes0302 clinical medicinePan europeanHumansMedicinecluster analysis ; international database ; personalized medicine ; phenotypes ; sleep apnoea.030212 general & internal medicineMedical prescriptionPrescribed medicationsComputingMilieux_MISCELLANEOUSSleep Apnea Obstructive[STAT.AP]Statistics [stat]/Applications [stat.AP]Databasebusiness.industryphenotypesEuropean populationpersonalized medicinemedicine.diseaseComorbidity3. Good healthPhenotype030228 respiratory systemFemalePersonalized medicinebusinesscomputersleep apnoea[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologycluster analysis
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THE EUROPEAN SLEEP APNOEA DATABASE (ESADA) -- Report from 22 European Sleep Laboratories

2011

The European Sleep Apnoea Database (ESADA) reflects a network of 22 sleep disorder centres in Europe enabled by a COST action B26 programme. This ongoing project aims to describe differences in standard clinical care of patients with obstructive sleep apnoea (OSA) and to establish a resource for genetic research in this disorder. Patients with suspected OSA are consecutively included and followed up according to local clinical standards. Anthropometrics, medical history, medication, daytime symptoms and sleep data (polysomnography or cardiorespiratory polygraphy) are recorded in a structured web-based report form. 5,103 patients (1,426 females, mean±SD age 51.8±12.6 yrs, 79.4% with apnoea/h…

Pulmonary and Respiratory MedicineAdultMalePediatricsmedicine.medical_specialtyAdolescentDatabases FactualCross-sectional studyPolysomnographyComorbidityCohort StudiesSleep Apnea SyndromesRisk FactorsSurveys and QuestionnairesmedicineHumansMedical historyRespiratory systemAgedSleep disordermedicine.diagnostic_testAnthropometryModels Geneticbusiness.industrycomorbidity European Sleep Apnoea Database genetic multicentre cohort obstructive sleep apnoea syndromeCardiorespiratory fitnessMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREAnthropometryMiddle Agedmedicine.diseaserespiratory tract diseasesObesity MorbidEuropeCohortFemaleHuman medicinebusiness
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Mild obstructive sleep apnoea (OSA) and arterial hypertension in the EuropeanSleep Apnoea Database (ESADA) cohort study.

2018

Background: Mild obstructive sleep apnoea (OSA) is highly prevalent, however its association with important clinical outcomes like arterial hypertension remains unknown. Aims and Objectives: To investigate the association between mild OSA and arterial hypertension in the European Sleep Apnoea Database (ESADA) cohort after adjusting for relevant confounding factors. Methods: A multicentric sample of 4974 adults from the ESADA cohort who showed simple snoring or mild OSA at cardiorespiratory polygraphy was studied. We compared the predictive value of mild OSA (AHI 5- Results: Arterial hypertension prevalence was 37% in mild OSA patients (n=2457) compared to 20% in non-apnoeic snorers (n=2517,…

medicine.medical_specialtybusiness.industryConfoundingCardiorespiratory fitnessPredictive valuenervous system diseasesrespiratory tract diseases03 medical and health sciences0302 clinical medicinestomatognathic system030228 respiratory systemHypertension prevalenceInternal medicineCohortCardiologyMedicine030212 general & internal medicinebusinessCohort studySleep and control of breathing
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Challenges and perspectives in obstructive sleep apnoea: Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Re…

2018

Obstructive sleep apnoea (OSA) is a major challenge for physicians and healthcare systems throughout the world. The high prevalence and the impact on daily life of OSA oblige clinicians to offer effective and acceptable treatment options. However, recent evidence has raised questions about the benefits of positive airway pressure therapy in ameliorating comorbidities.An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5 years, discussed the current challenges in the field, and proposed topics for future research on epidemiology, phenotyping, underlying mechanisms, prognostic implications and optimal treatment of pat…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyMEDLINEPolysomnographySettore MED/10 - Malattie Dell'Apparato Respiratoriosleepinesslaw.invention03 medical and health sciences0302 clinical medicineQuality of life (healthcare)Randomized controlled trialstomatognathic systemlawPositive airway pressureEpidemiologyMedicineIntensive care medicinesleep apnea: obstructivemedicine.diagnostic_testbusiness.industrySleep apneamedicine.diseaseComorbiditynervous system diseasesrespiratory tract diseasesdiagnosi030228 respiratory systemHuman medicinebusiness030217 neurology & neurosurgerysleep apnea phenotyping mechanisms
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Impact of temperature on obstructive sleep apnoea in three different climate zones of Europe: Data from the European Sleep Apnoea Database (ESADA)

2021

Recent studies indicate that ambient temperature may modulate obstructive sleep apnoea (OSA) severity. However, study results are contradictory warranting more investigation in this field. We analysed 19,293 patients of the European Sleep Apnoea Database (ESADA) cohort with restriction to the three predominant climate zones according to the Koppen-Geiger climate classification: Cfb (warm temperature, fully humid, warm summer), Csa (warm temperature, summer dry, hot summer), and Dfb (snow, fully humid, warm summer). Average outside temperature values were obtained and several hierarchical regression analyses were performed to investigate the impact of temperature on the apnea-hypopnea index …

Cognitive NeuroscienceSettore MED/10 - Malattie Dell'Apparato RespiratorioEnvironmentcomputer.software_genreBody Mass IndexCohort Studies03 medical and health sciencesBehavioral NeuroscienceSleep Apnea SyndromeSleep Apnea Syndromes0302 clinical medicineEnvironmental temperaturestomatognathic systemHumansMedicineOxygen saturation (medicine)Climate zonesSleep Apnea ObstructiveOxygen desaturationDatabasebusiness.industryTemperatureSleep Apnea Obstructive.General MedicineSleep in non-human animalsSleep-related breathing disordersnervous system diseasesrespiratory tract diseasesClinical neurologysleep&#8208030228 respiratory systemClimate zonerelated breathing disorderssleep-related breathing disorderHuman medicineCohort StudiebusinessBody mass indexcomputer030217 neurology & neurosurgeryHumanJournal of Sleep Research
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Severity Of Sleep Disordered Breathing Is An Independent Predictor Of Glycemic Health: The European Sleep Cohort (ESADA) Study

2012

medicine.medical_specialtybusiness.industryCohortSleep disordered breathingPhysical therapymedicineIndependent predictorbusinessSleep in non-human animalsGlycemicD18. SLEEP DISORDERED BREATHING AND METABOLIC FUNCTION: HOW UNSWEET IT IS
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Prevalence of physician-diagnosed asthma in patients with suspected obstructive sleep apnea syndrome: A cross-sectional analysis of the ESADA database

2015

It has been reported that bronchial asthma is often associated with obstructive sleep apnea (OSA) and daytime sleepiness. We analyzed the prevalence of physician-diagnosed asthma in 4929 subjects with suspected obstructive sleep apnea (OSA) in the European Sleep Apnea database (ESADA) Cohort. Patients were studied by respiratory polygraphy (PG: n=1624, 66.6% males) or full polysomnography (PSG: n=3305, 70.4% males), and the clinical characteristics of asthmatic (A) and non-asthmatic (non-A) patients were analyzed according to OSA severity. Significance was at p 2 , p=0.0004) and showed more severe daytime sleepiness (Epworth score: 10.4±5.6 vs 9.5±5.3, p=0.0015) and a trend for worse noctur…

medicine.medical_specialtymedicine.diagnostic_testbusiness.industryCross-sectional studySleep apneaPolysomnographymedicine.diseaserespiratory tract diseasesObstructive sleep apneaInternal medicineCohortmedicinePhysical therapyAsthmatic patientIn patientbusinessAsthma4.2 Sleep and Control of Breathing
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Regional differences in characteristics of patients referred to European sleep centers. Results from the European Sleep Apnea Database (ESADA)

2012

SLEEP APNEASettore MED/10 - Malattie Dell'Apparato Respiratorio
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Blood pressure reduction following treatment with positive airway pressure in sleep apnea: data from the European Sleep Apnea Database

2020

Abstract Introduction Positive airway pressure (PAP) treatment modifies blood pressure (BP) in patients with obstructive sleep apnea (OSA). We aimed to explore which factors that influence the BP response to PAP therapy in the European Sleep Apnea Database (ESADA). Methods A total of 2662 OSA patients with PAP therapy ≥90 days were included in the analysis (74% male, age 55±11 years, body mass index 32.3±6.1 kg/m2, 47% hypertensives, apnea-hypopnea index 40±24 events/h, treatment duration 1.0±1.1 years, PAP compliance 5.2±1.9 h/day). Anthropometric data, co-medications and office BP were assessed at baseline and follow-up visit. Results Systolic and diastolic BP were modestly reduced after …

medicine.medical_specialtybusiness.industrymedicine.medical_treatmentSleep apneamedicine.diseaseObstructive sleep apneaBlood pressureSleep apnea syndromesWeight lossInternal medicinePositive airway pressuremedicineCardiologymedicine.symptomCardiology and Cardiovascular MedicinebusinessReduction (orthopedic surgery)European Heart Journal
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Obstructive sleep apnea is an independent predictor for dyslipidemia: Data from the European Sleep Apnea Database (ESADA)

2017

Background and aim: Obstructive sleep apnea (OSA) and dyslipidemia are both independently well-recognized risk factors for cardiovascular disease. Previous data are inconclusive regarding the relationship between OSA and dyslipidemia. The aim of the present study was to investigate the association between OSA and dyslipidemia in ESADA (European Sleep Apnea Database). Methods: The cross-sectional analysis included 8592 patients (age 50.1±12.7 years, 69.1% male, BMI 30.8±6.6 kg/m2, mean AHI 25.7±25.9 n/h) from the ESADA. The independent relationship between measures of OSA (AHI, ODI, mean and lowest saturation) and lipid profile (total cholesterol [TC], HDL-cholesterol [HDL-C] (n=3289) and fa…

medicine.diagnostic_testTriglycerideDatabasebusiness.industrynutritional and metabolic diseasesSleep apneamedicine.diseaseIndependent predictorcomputer.software_genrerespiratory tract diseasesObstructive sleep apneachemistry.chemical_compoundchemistryTotal cholesterolHyperlipidemiamedicineLipid profilebusinesscomputerDyslipidemiaSleep and Control of Breathing
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Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study

2019

[No abstract available]

MaleobesityLetterDatabases FactualDownload[SDV]Life Sciences [q-bio]cigarette smokingPolysomnographycancer riskdisease burdenapnea hypopnea indexsleep disordered breathingstudy design0302 clinical medicinepolysomnographyRisk FactorsNothingcancer diagnosisNeoplasmsmiddle agedgenderPrevalence030212 general & internal medicineSleep studyobstructive sleep apneaSleep Apnea Obstructiveeducation.field_of_studyanthropometryquantitative analysismedicine.diagnostic_testadultrisk assessmentclinical trialcohort analysisprostate cancerpulse oximetry[SDV] Life Sciences [q-bio]Europenot availablecomorbidityagedfemalewaist hip ratiocolon cancerpriority journalrisk factorfactual databasedisease severitycerebrovascular accidentPulmonary and Respiratory Medicinemedicine.medical_specialtyalcohol consumptionintermittent hypoxiaPopulationMEDLINElymphomaSettore MED/10 - Malattie Dell'Apparato Respiratoriomalignant neoplasmcancer growth03 medical and health sciencesmelanomamedicinecancercross-sectional studyHumanscontrolled studyhumaneducationCancer prevalencehypoxiabusiness.industrystatistical modelConflict of interestpredictionmajor clinical studybody massoxygen saturationlung cancermulticenter studyCross-Sectional StudiesLogistic Modelsage030228 respiratory systemdisease severity assessmentFamily medicineoxygen desaturation indexhead and neck cancerHuman medicinebusinessneoplasmEuropean Respiratory Journal
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Comment to the Editorial by KS Park and EW Kang “Is only fixed positive airway pressure a robust tool for kidney protection in patients with obstruct…

2019

We thank doctors Park and Kang for their editorial that well summarized our article. Our common belief is that one of the possible consequences of untreated obstructive sleep apnea (OSA) is an accelerated deterioration of kidney function, and that more knowledge would be necessary on the possible protective effects of OSA treatments. To our knowledge, so far the only OSA therapy whose effects on renal function have been tested is continuous positive airway pressure (CPAP), and most , although not all studies, have demonstrated its benefits. Our own study, while confirming benefits of fixed CPAP, has demonstrated little effect of auto-adjusting CPAP (APAP). This finding may be of relevance a…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyLetterestimated glomerular filtration ratekidney diseaseRenal functionPolysomnographySettore MED/10 - Malattie Dell'Apparato Respiratoriosleep disordered breathingpolysomnographyrenal protectionPositive airway pressureMedicineIn patienthumansleepIntensive care medicinekidney functionLetter to the EditorPositive end-expiratory pressureKidneymedicine.diagnostic_testbusiness.industryobstructive sleep apnea ; kidney protection ; fixed positive airway pressuremedicine.diseaseoxygen saturationrespiratory tract diseasesObstructive sleep apneaNot availablemedicine.anatomical_structureEditorialpositive end expiratory pressureHuman medicinebusinesschronic obstructive lung diseaseKidney disease
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Evaluation of a multicomponent grading system for obstructive sleep apnoea: the Baveno classification

2021

New findings on pathophysiology, epidemiology, and outcome have raised concerns on the relevance of the apnoea–hypopnoea index (AHI) in the classification of obstructive sleep apnoea (OSA) severity. Recently, a multicomponent grading system decision integrating symptomatology and comorbidities (Baveno classification), was proposed to characterise OSA and to guide therapeutic decisions. We evaluated whether this system reflects the OSA population, whether it translates into differences in outcomes, and whether the addition of AHI improves the scheme. A total of 14 499 OSA patients from the European Sleep Apnoea Database cohort were analysed. The groups were homogeneously distributed and were…

Pulmonary and Respiratory Medicinemedicine.medical_specialty5RulesPopulationMEDLINElcsh:Medicine03 medical and health sciencesPrevalent0302 clinical medicinestomatognathic systemHypopneaInternal medicineEpidemiologymedicineResistant Hypertensioneducationeducation.field_of_studybusiness.industrylcsh:ROriginal Articlesnervous system diseasesrespiratory tract diseases[SDV] Life Sciences [q-bio]Blood pressure030228 respiratory systemPositive Airway PressureCohortHuman medicineTreatment decision makingSleepbusiness030217 neurology & neurosurgeryERJ Open Research
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Obstructive sleep apnoea in adult patients post-tonsillectomy

2021

Background: The impact of removing the upper airway lymphoid tissue and in particular, tonsillectomy, in adults with OSA has not been demonstrated in large populations. Aims: To compare the severity of OSA and the prevalence of cardiovascular, metabolic and respiratory co-morbidities between patients with OSA who had undergone previous tonsillectomy and those who had not. Methods: The 19,711 participants in this study came from the European sleep apnea database (ESADA) which comprises data from unselected adult patients aged 18–80 years with a history of symptoms suggestive of OSA referred to sleep centers throughout Europe. Results: There were no differences between the two groups in terms…

AdultPediatricsmedicine.medical_specialtymedicine.medical_treatment[SDV]Life Sciences [q-bio]ESADALymphoid tissue overgrowthSettore MED/10 - Malattie Dell'Apparato Respiratorio03 medical and health sciencesSleep apnoea0302 clinical medicinemedicineHumansMass indexRespiratory systemTonsillectomySleep Apnea ObstructiveAdult patientsbusiness.industrySleep apneaGeneral MedicineESADA ; Lymphoid tissue overgrowth ; Sleep apnoea ; Tonsillectomy.medicine.diseaseSleep in non-human animalsrespiratory tract diseasesTonsillectomy[SDV] Life Sciences [q-bio]Europe030228 respiratory systemDiabetes Mellitus Type 2Lower prevalenceTonsillectomy.AirwaybusinessSleep030217 neurology & neurosurgery
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Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA

2018

Abstract: BACKGROUND: The impact of treating OSA on renal function decline is controversial. Previous studies usually included small samples and did not consider specific effects of different CPAP modalities. The aim of this study was to evaluate the respective influence of fixed and autoadjusting CPAP modes on estimated glomerular filtration rate (eGFR) in a large sample of patients derived from the prospective European Sleep Apnea Database cohort. METHODS: In patients of the European Sleep Apnea Database, eGFR prior to and after follow-up was calculated by using the Chronic Kidney Disease-Epidemiology Collaboration equation. Three study groups were investigated: untreated patients (n = 14…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyUrologyRenal functionSettore MED/10 - Malattie Dell'Apparato RespiratorioEgfr declineCritical Care and Intensive Care MedicineOSA03 medical and health sciences0302 clinical medicinePositive airway pressuremedicineautomatic CPAPIn patientKidneyglomerular filtration ratetherapybusiness.industrySleep apneafixed CPAPta3121medicine.diseaserespiratory tract diseasesLarge samplemedicine.anatomical_structure030228 respiratory systemCohortHuman medicinebusinessCardiology and Cardiovascular Medicine030217 neurology & neurosurgery
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Excessive Daytime Sleepiness in Obstructive Sleep Apnea Patients Treated With Continuous Positive Airway Pressure: Data From the European Sleep Apnea…

2021

Excessive daytime sleepiness (EDS) is a symptom of obstructive sleep apnea (OSA) that resolves under treatment with continuous positive airway pressure (CPAP). In some patients, sleepiness persists despite CPAP treatment. We retrospectively analyzed data on subjective residual EDS, assessed as an Epworth Sleepiness Scale score (ESS) >10, in patients from the European Sleep Apnea Database (n = 4,853, mean age +/- SD 54.8 +/- 11.8 years, 26.1% females), at baseline and at the first visit (median follow-up: 5 months, interquartile range 3-13). An ESS > 10 occurred in 56% of patients at baseline and in 28.2% of patients at follow-up. Residual EDS was analyzed in 2,190 patients (age: 55.1 +/- 12…

sleep latencyResidual Sleepinessmedicine.medical_treatment[SDV]Life Sciences [q-bio]Excessive daytime sleepinessSettore MED/10 - Malattie Dell'Apparato Respiratoriocomputer.software_genreCpap adherence03 medical and health sciences0302 clinical medicineInterquartile rangeCpap Usemedicinefollow-upContinuous positive airway pressureObesityRC346-429ComputingMilieux_MISCELLANEOUSresidual sleepnessOriginal ResearchWake-Active NeuronsDatabasebusiness.industryresidual sleepineEpworth Sleepiness ScaleSleep apneaEpworth sleepness ScaleEpworth Sleepiness Scalemedicine.diseaseCPAP adherenceImportant Differencenervous system diseasesrespiratory tract diseasesScaleObstructive sleep apneaLifestyle factors030228 respiratory systemNeurologysleep durationHuman medicineNeurology. Diseases of the nervous systemNeurology (clinical)medicine.symptombusinesscomputer030217 neurology & neurosurgery
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Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database

2018

Background and objective: Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 8592 patients without physician-diagnosed hyperlipidaemia or reported intake of a lipid-lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnoea–hypopnoea index (AHI): 25.7 ± 25.9 events/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profil…

MaleobesityDatabases Factualcholesterol dyslipidemia hypoxia obesity sleep apnoeaGastroenterologyCohort Studieschemistry.chemical_compound0302 clinical medicineRisk FactorsHypolipidemic AgentsOxygen saturation (medicine)Sleep Apnea Obstructivemedicine.diagnostic_testSleep apneaMiddle AgedEuropeQuartileCardiovascular DiseasesCohortFemalelipids (amino acids peptides and proteins)AdultPulmonary and Respiratory Medicinemedicine.medical_specialtySettore MED/10 - Malattie Dell'Apparato Respiratorio03 medical and health sciencesInternal medicinemedicineHumansTriglyceridesDyslipidemiashypoxiaCholesterolbusiness.industryCholesterol HDLdyslipidemiacholesterolCholesterol LDLta3121medicine.diseaseObesitynervous system diseasesrespiratory tract diseasesCross-Sectional Studies030228 respiratory systemchemistryLipid profilebusinesssleep apnoea030217 neurology & neurosurgeryDyslipidemiaRespirology
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Unique sleep-stage transitions determined by obstructive sleep apnea severity, age and gender

2019

In obstructive sleep apnea, patients' sleep is fragmented leading to excessive daytime sleepiness and co-morbidities like arterial hypertension. However, traditional metrics are not always directly correlated with daytime sleepiness, and the association between traditional sleep quality metrics like sleep duration and arterial hypertension is still ambiguous. In a development cohort, we analysed hypnograms from mild (n = 213), moderate (n = 235) and severe (n = 277) obstructive sleep apnea patients as well as healthy controls (n = 105) from the European Sleep Apnea Database. We assessed sleep by the analysis of two-step transitions depending on obstructive sleep apnea severity and anthropom…

AdultMalesleep-disordered breathing.medicine.medical_specialtysleepdisordered breathing[SDV]Life Sciences [q-bio]Cognitive Neurosciencesleep dynamicsExcessive daytime sleepinessSettore MED/10 - Malattie Dell'Apparato Respiratorio600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheitenpower-law distribution03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineInternal medicine616HumansMedicineexponential distributionsleep fragmentationStage (cooking)Retrospective StudiesSleep Apnea Obstructivebusiness.industryConfoundingsleep-disordered breathingAge FactorsGender IdentitySleep apneaGeneral MedicineMiddle AgedAnthropometrymedicine.diseaseSleep in non-human animals[SDV] Life Sciences [q-bio]Obstructive sleep apnea030228 respiratory systemsleep dynamicCohortCardiologyFemaleHuman medicinemedicine.symptomSleepbusiness030217 neurology & neurosurgery
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Reference values for mean overnight saturation in sleep apnoea – the European Sleep Apnoea Database (ESADA)

2020

Introduction: Normative values for mean overnight oxygen saturation during sleep in apnoea patients stratified for age, BMI, and sleep apnoea severity are lacking. Aim: To establish reference intervals for overnight mean saturation in a large sleep apnoea patient cohort. Methods: Mean overnight oxygen saturation was analysed in adult patients (n=23,220) from the European Sleep Apnoea Database (ESADA, 30 sleep centres, 18 European countries). Data were classified according to age, gender, BMI ( Results: Mean overnight saturation was 93.0% (95% confidence interval (CI) 92.9 to 93.1%). Age influenced the adjusted mean nocturnal saturation (93.6%, 93.2%, 92.9%, 92.5%, 92.2% and 91.9% for those …

medicine.medical_specialtyDatabasebusiness.industryConfoundingcomputer.software_genreApnoea / HypopneaSleep medicineSleep in non-human animalsConfidence intervalReference valuesparasitic diseasesCohortmedicinebusinessSaturation (chemistry)computerOxygen saturation (medicine)Sleep and control of breathing
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Mild OSA and arterial hypertension in the European Sleep Apnoea Database cohort study

2019

Background: Mild obstructive sleep apnoea (OSA) is highly prevalent; however its association with important clinical outcomes like arterial hypertension remains unknown. Aims: To investigate the association between mild OSA and hypertension in the European Sleep Apnoea Database (ESADA) cohort after adjusting for relevant confounding factors. Methods: A multicentric sample of 7995 adults from the ESADA cohort with simple snoring or mild OSA at PG or PSG was studied. We compared the predictive value of mild OSA (AHI 5- Results: Arterial hypertension prevalence was 37% in mild OSA  (n=1566) compared to 22% in non-apnoeic snorers (n=793, p Conclusion: Our results suppport the hypothesis that mi…

Databasebusiness.industryConfoundingcomputer.software_genreSleep in non-human animalsPredictive valuenervous system diseasesrespiratory tract diseasesstomatognathic systemHypertension prevalenceCohortMedicineRisk factorbusinesscomputerCohort studyObstructive Sleep Apnoea
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Hyperlipidemia Prevalence and Cholesterol Control in OSA: Data from European Sleep Apnea Database (ESADA)

2019

European-Respiratory-Society (ERS) International Congress -- SEP 28-OCT 02, 2019 -- Madrid, SPAIN

medicine.medical_specialtyCholesterolbusiness.industryConfoundingnutritional and metabolic diseasesSleep apneaDiseasemedicine.diseasenervous system diseasesrespiratory tract diseasesObstructive sleep apneachemistry.chemical_compoundstomatognathic systemchemistryInternal medicineCohortHyperlipidemiamedicineIn patientbusinessHypoxia
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Effects of sleep apnea and kidney dysfunction on objective sleep quality in nondialyzed patients with chronic kidney disease: an ESADA study

2020

Study Objectives: Patients with chronic kidney disease (CKD) often report poor sleep quality, but they commonly exhibit OSA. The aim of this study was to evaluate the influence of OSA severity and of estimated glomerular filtration rate impairment on objective sleep quality in nondialyzed patients with CKD, defined as an estimated glomerular filtration rate &lt;60 mL/min/1.73m2. Methods: Polysomnographic sleep characteristics were compared between patients with (n = 430) and without CKD (n = 6,639) in the European Sleep Apnea Database cohort. Comparisons were repeated in 375 patients with CKD and 375 control patients without CKD matched for sleep center, age, sex, and AHI, and in 310 matche…

Chronic kidney disease ; Estimated glomerular filtration rate ; Sleep apnea ; Sleep qualitysleep quality.Pulmonary and Respiratory Medicinemedicine.medical_specialtyRenal functionSettore MED/10 - Malattie Dell'Apparato RespiratorioKidneyurologic and male genital diseases03 medical and health sciencesSleep Apnea Syndromes0302 clinical medicinestomatognathic systemChronic kidney diseaseInternal medicineHumansMedicineEstimated glomerular filtration rateRenal Insufficiency ChronicSleep Apnea ObstructiveSleep qualitybusiness.industrySleep apneaKidney dysfunctionSleep apneaSleep qualitymedicine.diseaseScientific Investigationsfemale genital diseases and pregnancy complicationsnervous system diseasesrespiratory tract diseasesPoor sleep030228 respiratory systemNeurologyHuman medicineNeurology (clinical)Sleepbusiness030217 neurology & neurosurgeryKidney diseaseJournal of Clinical Sleep Medicine
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EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke.

2020

BACKGROUND Sleep disorders are highly prevalent in the general population and may be linked in a bidirectional fashion to stroke, which is one of the leading causes of morbidity and mortality. AIM Four major scientific societies established a task force of experts in neurology, stroke, respiratory medicine, sleep medicine and methodology to critically evaluate the evidence regarding potential links and the impact of therapy. MATERIALS AND METHODS Thirteen research questions were evaluated in a systematic literature search using a stepwise hierarchical approach: first, systematic reviews and meta-analyses; second, primary studies post-dating the systematic reviews/meta-analyses. A total of 4…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyPeriodic limb movement disorderNeurologymedicine.medical_treatmentinsomniaPopulationsleep apnea RLS insomnia strokerestless legs030204 cardiovascular system & hematologySettore MED/10 - Malattie Dell'Apparato RespiratorioSleep medicine03 medical and health sciencessleep disordered breathing0302 clinical medicineRestless Legs SyndromeSleep Initiation and Maintenance DisordersInsomniamedicinePrevalenceinsomnia outcome PLMS restless legs risk sleep disordered breathing sleep disorders strokeHumansContinuous positive airway pressure030212 general & internal medicineRisk factoreducationIntensive care medicinePLMSStrokeriskeducation.field_of_studySleep disorderSleep Apnea ObstructiveContinuous Positive Airway Pressurebusiness.industryMiddle Agedmedicine.diseasestrokeStrokeSystematic reviewNeurologyMeta-analysisoutcomesleep disordersNeurology (clinical)medicine.symptombusiness030217 neurology & neurosurgeryThe European respiratory journal
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Cardiometabolic impact and symptom profile of obstructivesleep apnea: does gender matter?

2019

European-Respiratory-Society (ERS) International Congress -- SEP 28-OCT 02, 2019 -- Madrid, SPAIN

medicine.medical_specialtybusiness.industryEpworth Sleepiness ScaleConfoundingSleep apneaApneaOdds ratiomedicine.diseaseApnoea / HypopneaObstructive sleep apneaInternal medicineCohortmedicineInsomniamedicine.symptombusiness
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