6533b851fe1ef96bd12aa135

RESEARCH PRODUCT

Obstructive sleep apnea is an independent predictor for dyslipidemia: Data from the European Sleep Apnea Database (ESADA)

Ding ZouFerran BarbéAthanasia PatakaOzen K. BasogluJan HednerCanan GunduzPavel SliwinskyLudger GroteRichard StaatsHolger HeinMaria R. Bonsignore

subject

medicine.diagnostic_testTriglycerideDatabasebusiness.industrynutritional and metabolic diseasesSleep apneamedicine.diseaseIndependent predictorcomputer.software_genrerespiratory tract diseasesObstructive sleep apneachemistry.chemical_compoundchemistryTotal cholesterolHyperlipidemiamedicineLipid profilebusinesscomputerDyslipidemia

description

Background and aim: Obstructive sleep apnea (OSA) and dyslipidemia are both independently well-recognized risk factors for cardiovascular disease. Previous data are inconclusive regarding the relationship between OSA and dyslipidemia. The aim of the present study was to investigate the association between OSA and dyslipidemia in ESADA (European Sleep Apnea Database). Methods: The cross-sectional analysis included 8592 patients (age 50.1±12.7 years, 69.1% male, BMI 30.8±6.6 kg/m2, mean AHI 25.7±25.9 n/h) from the ESADA. The independent relationship between measures of OSA (AHI, ODI, mean and lowest saturation) and lipid profile (total cholesterol [TC], HDL-cholesterol [HDL-C] (n=3289) and fasting triglyceride [TG] (n=4612)) was determined by means of General Linear Model analysis. Patients with known hyperlipidemia and/or lipid-lowering medication were excluded. Results: TC had a strong linear association with ODI (mean±SE [mg/dl] 180.33±2.46, 184.59±2.42, 185.44±2.42 and 185.73±2.44; p Conclusion: OSA has an independent association with dyslipidemia, but the effect size is limited.

yearjournalcountryeditionlanguage
2017-09-01Sleep and Control of Breathing
https://doi.org/10.1183/1393003.congress-2017.oa3208