0000000000022437
AUTHOR
Maria Carmen Gomez-cabrera
Role of Free Radicals and Antioxidant Signaling in Skeletal Muscle Health and Pathology
Skeletal muscle contraction, growth, differentiation and adaptation are governed by complicated biological mechanisms still being studied intensively. Generation of reactive oxygen and nitrogen species (RS) is one of the most prominent events during contractile activity that could influence muscle function and health. While RS generation is known to cause oxidative stress, activate certain pathogenic pathways and aging, they also serve as useful signaling molecules to regulate gene expression of proteins and enzymes that play a vital role in the normal muscle function and defense against detrimental effects of RS. The purpose of the present review is two-fold: first, to provide an overview …
Endocrinology of Aging From a Muscle Function Point of View: Results From the Toledo Study for Healthy Aging.
Aging is a process that involves a reduction in muscle strength and anabolic hormone concentrations, which impacts significantly on health.To study the hormone/total strength (H/TS) ratio as a proxy of anabolic insensitivity status in elders, and its relationship with disability, hospitalization, and mortality risk.A total of 1462 persons aged ≥65 years from the Toledo Study of Healthy Aging participated in this study. Serum concentrations of insulin like growth factor 1, total and free testosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate, and 17β-estradiol were measured. Total maximal voluntary isometric strength was obtained (handgrip, shoulder, hip, and knee) using standa…
Prevalencia de sarcopenia en consultas de geriatría y residencias. Estudio ELLI
Resumen Introduccion Existen hasta ahora pocos estudios sistematicos con los nuevos criterios diagnosticos sobre la prevalencia de la sarcopenia en distintos niveles asistenciales geriatricos. Objetivo Conocer la prevalencia de sarcopenia, aplicando los criterios y el algoritmo diagnostico propuesto por el European Working Group on Sarcopenia in older People (EWGSOP), en personas mayores que acuden a consultas externas de geriatria y en aquellas que estan ingresadas en residencias. Material y metodos Estudio multicentrico nacional en 2 muestras de personas mayores: una formada por aquellas que acuden a consultas externas de geriatria hospitalarias, y la otra por aquellas que estan ingresada…