Acute hepatotoxicity induced by quetiapine fumarate in larval zebrafish

Effects of side chains of oxatub[4]arene on its conformational interconversion, molecular recognition and macroscopic self-assembly.

A series of oxatub[4]arenes with different alkyl side chains have been synthesized. The conformational interconversion, molecular recognition and macroscopic self-assembly behaviour of oxatub[4]arene derivatives were investigated. The difference in side chains slightly changes the binding affinities, but results in different self-assembly morphologies at the solid state.

Redox-Responsive Host-Guest Chemistry of a Flexible Cage with Naphthalene Walls

“Naphthocage”, a naphthalene-based organic cage, reveals very strong binding (up to 1010 M–1) to aromatic (di)cationic guests, i.e., the tetrathiafulvalene mono- and dication and methyl viologen. Intercalation of the guests between two naphthalene walls is mediated by C–H···O, C–H···π, and cation···π interactions. The guests can be switched into and out of the cage by redox processes with high binding selectivity. Oxidation of the flexible cage itself in the absence of a guest leads to a stable radical cation with the oxidized naphthalene intercalated between and stabilized by the other two. Encapsulated guest cations are released from the cavity upon cage oxidation, paving the way to futur…

Redox-Responsive Host–Guest Chemistry of a Flexible Cage with Naphthalene Walls

"Naphthocage", a naphthalene-based organic cage, reveals very strong binding (up to 1010 M-1) to aromatic (di)cationic guests, i.e., the tetrathiafulvalene mono- and dication and methyl viologen. Intercalation of the guests between two naphthalene walls is mediated by C-H···O, C-H···π, and cation···π interactions. The guests can be switched into and out of the cage by redox processes with high binding selectivity. Oxidation of the flexible cage itself in the absence of a guest leads to a stable radical cation with the oxidized naphthalene intercalated between and stabilized by the other two. Encapsulated guest cations are released from the cavity upon cage oxidation, paving the way to futur…

Guest-Induced Folding and Self-Assembly of Conformationally Adaptive Macrocycles into Nanosheets and Nanotubes

A conformationally adaptive macrocycle is presented, namely zorb[4]arene, which exists in multiple conformations in the uncomplexed state. The binding cavity of zorb[4]arene is concealed, either due to a collapsed conformation or by self-inclusion. The zorb[4]arene with long alkyl chains manifests itself with surprisingly low melting point and thus exist as an oil at room temperature. Binding of a guest molecule induces the folding and conformational rigidity of zorb[4]arene and leads to well-defined three-dimensional structures, which can further self-assemble into nanosheets or nanotubes upon solvent evaporation, depending on guest molecules and the conformations they can induce.

CCDC 1577176: Experimental Crystal Structure Determination

Related Article: Liu-Pan Yang, Fei Jia, Fangfang Pan, Zhi-Sheng Pan, Kari Rissanen, Wei Jiang|2017|Chem.Commun.|53|12572|doi:10.1039/C7CC07630D

CCDC 1957981: Experimental Crystal Structure Determination

Related Article: Fei Jia, Hendrik V. Schröder, Liu-Pan Yang, Carolina von Essen, Sebastian Sobottka, Biprajit Sarkar, Kari Rissanen, Wei Jiang, Christoph A. Schalley|2020|J.Am.Chem.Soc.|142|3306|doi:10.1021/jacs.9b11685

CCDC 1482002: Experimental Crystal Structure Determination

Related Article: Liu-Pan Yang, Fei Jia, Qing-Hai Zhou, Fangfang Pan, Jiao-Nan Sun, Kari Rissanen, Lung Wa Chung, Wei Jiang|2017|Chem.-Eur.J.|23|1516|doi:10.1002/chem.201605701

CCDC 1482001: Experimental Crystal Structure Determination

Related Article: Liu-Pan Yang, Fei Jia, Qing-Hai Zhou, Fangfang Pan, Jiao-Nan Sun, Kari Rissanen, Lung Wa Chung, Wei Jiang|2017|Chem.-Eur.J.|23|1516|doi:10.1002/chem.201605701