0000000000023225

AUTHOR

Minna Männikkö

showing 2 related works from this author

Polygenic Risk Scores and Physical Activity

2020

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MaleMultifactorial InheritanceEpidemiologyheritabilityNorthern finlandDISEASEhidden heritability0302 clinical medicineRisk FactorsMISSING HERITABILITYAccelerometryMedicineOrthopedics and Sports Medicine315 Sport and fitness sciencesgeneskrooniset tauditFinlandAged 80 and overeducation.field_of_studyFramingham Risk ScoreBIRTH COHORTexerciseHERITABILITYObjective measurementriskitekijätMiddle Aged3. Good healthComputingMethodologies_DOCUMENTANDTEXTPROCESSINGFemaleHEALTHgeenitutkimusBirth cohortfyysinen aktiivisuusAdultSingle variableAdolescentGenotypePopulationPhysical activityEXERCISEPhysical Therapy Sports Therapy and RehabilitationFitness TrackersGENOTYPE IMPUTATIONPolymorphism Single Nucleotideperinnöllinen alttiusYoung Adult03 medical and health sciencesHumansGENOME-WIDE ASSOCIATIONgeneeducationperinnöllisyysAgedgeenitbusiness.industryHIDDEN HERITABILITY030229 sport sciencesGENEperimäPolygenic risk scoreSelf ReportbusinessGenome-Wide Association StudyDemographyMedicine & Science in Sports & Exercise
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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic inf…

2018

AbstractHumans vary substantially in their willingness to take risks. In a combined sample of over one million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. We identified 611 approximately independent genetic loci associated with at least one of our phenotypes, including 124 with general risk tolerance. We report evidence of substantial shared genetic influences across general risk tolerance and risky behaviors: 72 of the 124 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is moderately to stro…

Genetics0303 health sciencesGabaergic neurotransmissionSingle-nucleotide polymorphismGenome-wide association studyBiologyPhenotype03 medical and health sciences0302 clinical medicineSNPGene030217 neurology & neurosurgery030304 developmental biologyGenetic association
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