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RESEARCH PRODUCT
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences1
Edward KongPascal TimshelPascal TimshelDanielle PosthumaTõnu EskoMaël LebretonKathleen Mullan HarrisPhilipp KoellingerPhilipp KoellingerMurray B. SteinAbraham A. PalmerUrs FischbacherRobert J. UrsanoErdogan TaskesenPeter EibichPeter EibichPeter EibichPaul R. H. J. TimmersAnke R. HammerschlagAnn H. CaplinJian YangSandra Sanchez-roigePeter K. JoshiMatthias SutterMatthias SutterPierre FontanillasChia-yen ChenChia-yen ChenAlbert HofmanAlbert HofmanPatrick TurleyPatrick TurleyPatrick TurleyDavid A. HindsFutao ZhangDavid CesariniChristina M. LillLaura BuzduganVille KarhunenAbdel AbdellaouiS. Fleur W. MeddensS. Fleur W. MeddensHenning TiemeierChristian L. ZundGert G. WagnerGert G. WagnerRichard Karlsson LinnérRichard Karlsson LinnérLars BertramLars BertramDavid W. ClarkRoy ThurikAndré G. UitterlindenMaciej TrzaskowskiMohammad Arfan IkramDavid LaibsonCornelius A. RietveldArcadi NavarroArcadi NavarroErnst FehrYang WuMatthew B. McqueenRonald C. KesslerMagnus JohannessonPatrick J. F. GroenenGregor HaslerJames F. WilsonJames F. WilsonDaniel SchunkStephen P. TinoPietro BiroliMark Alan FontanaMark Alan FontanaJuan R. GonzálezMeena KumariGerardus A. MeddensJonathan P. BeauchampMichelle N. MeyerJason D. BoardmanJames J. LeeCarlos Morcillo-suarezAaron KleinmanMinna MännikköAndrew ConlinAdam AutonTune H. PersTune H. PersMichel G. NivardRonald De VlamingRonald De VlamingJon WhiteRobert KarlssonDaniel J. BenjaminDaniel J. BenjaminDaniel J. BenjaminMaarten KooymanJacob GrattenAysu OkbayRemy Z. LevinMelissa C. SmartHarriet De WitConor C. DolanFrank J. A. Van RooijPatrik K. E. MagnussonSonia JainRauli SventoKlaus M. SchmidtDorret I. BoomsmaGerard MuntanéJames MackillopRobbee WedowYanchun Baosubject
Genetics0303 health sciencesGabaergic neurotransmissionSingle-nucleotide polymorphismGenome-wide association studyBiologyPhenotype03 medical and health sciences0302 clinical medicineSNPGene030217 neurology & neurosurgery030304 developmental biologyGenetic associationdescription
AbstractHumans vary substantially in their willingness to take risks. In a combined sample of over one million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. We identified 611 approximately independent genetic loci associated with at least one of our phenotypes, including 124 with general risk tolerance. We report evidence of substantial shared genetic influences across general risk tolerance and risky behaviors: 72 of the 124 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is moderately to strongly genetically correlated (to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near general-risk-tolerance-associated SNPs are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We find no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-02-08 |