0000000000023633

AUTHOR

Leonardo Antonicelli

showing 9 related works from this author

The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in It…

2022

Early life conditions are associated with lung function and the development of respiratory and non-respiratory illnesses. The relationship with birthweight (BW), however, is conflicting. We examined associations of self-reported BW with lung function and the development of respiratory and also non-respiratory diseases within the GEIRD (Gene–Environment Interaction in Respiratory Diseases) project, an Italian multi-centre, multi-case control study involving cases of COPD, asthma, allergic rhinitis and controls. Multinomial logistic regression was performed with case/control status as response variable; BW as main determinant; and adjusting for sex, age and smoking status. Of the 2287 p…

MaleAdultrespiratory healthadult health; birthweight; early life; lung volumes; respiratory diseases; respiratory healthrespiratory diseasesHealth Toxicology and Mutagenesisadult healthPublic Health Environmental and Occupational Healthrespiratory health.Settore MED/10 - Malattie Dell'Apparato RespiratorioRespiration Disordersrespiratory diseaseItalybirthweightCase-Control StudiesHumansBirth Weightearly lifeFemaleSelf Reportlung volumelung volumesLungInternational Journal of Environmental Research and Public Health
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Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases

2019

Background and objectives Cardiovascular and respiratory diseases can frequently coexist. Understanding their link may improve disease management. We aimed at assessing the associations of chronic bronchitis (CB), asthma and rhinitis with cardiovascular diseases and risk factors in the general population. Methods We used data collected in the Gene Environment Interactions in Respiratory Diseases study, an Italian multicentre, multicase-control study. Among 2463 participants (age 21–86, female 50%) who underwent standardized interviews, skin prick and lung function tests, we identified 254 cases of CB without airflow obstruction, 418 cases of asthma without CB, 959 cases of rhinitis alone, a…

MaleLUNG-DISEASEChronic bronchitisPulmonologyEpidemiologyBlood PressureCardiovascular Medicine030204 cardiovascular system & hematologyVascular Medicine[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tractCohort StudiesPulmonary Disease Chronic Obstructive0302 clinical medicineRisk FactorsMedicine and Health SciencesOdds Ratiochronic bronchitiLungRhinitisAged 80 and overeducation.field_of_studyAlcohol ConsumptionMultidisciplinaryQRHeartMiddle AgedCardiovascular diseaseCBRespiratory Function Tests3. Good healthPREVALENCE[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemBronchitis ChronicALLERGIC RHINITISINTERMITTENT CLAUDICATIONCardiovascular DiseasesHypertensionBronchitisMedicinechronic bronchitisFemaleAnatomymedicine.symptomResearch ArticleAdultmedicine.medical_specialtySciencePopulationbody mass indexSettore MED/10 - Malattie Dell'Apparato RespiratorioDIAGNOSISelderlychronic obstructive pulmonary diseaseYoung Adult03 medical and health sciencesHeart disorderBMI[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemInternal medicineConfidence IntervalsmedicineHumansCOPDCORONARY-HEART-DISEASEBronchitiseducationNutritionAgedAsthmaCORONARY-HEART-DISEASE; ALLERGIC RHINITIS; INTERMITTENT CLAUDICATION; MYOCARDIAL-INFARCTION; MUCUS HYPERSECRETION; CIGARETTE-SMOKING; LUNG-DISEASE; DIAGNOSIS; ATHEROSCLEROSIS; PREVALENCEbusiness.industryBiology and Life SciencesOdds ratioRhinologyasthmamedicine.diseaseIntermittent claudicationDietOtorhinolaryngology030228 respiratory systemMYOCARDIAL-INFARCTIONATHEROSCLEROSISMUCUS HYPERSECRETION[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologieMedical Risk FactorsCase-Control StudiesRelative riskNasal DiseasesCardiovascular Anatomy[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieCIGARETTE-SMOKINGbusinessBMI body mass index; CB chronic bronchitis; COPD chronic obstructive pulmonary disease;
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Late-asthma onset and associated factors

2016

Although asthma is usually considered to originate in childhood, adult-onset is being increasingly reported. Aim: to assess factors associated to early- (<18 yrs) and late-onset (≥18 yrs) asthma. Methods: Data from a web-based Italian severe/uncontrolled asthma (SUA) registry (released in 2014), including 577 SUA subjects from 6 clinical and epidemiological Italian centres (Pisa1, Perugia, Ancona, Verona, Palermo, Pisa2). Results: 77.5% of SUA subjects had a late-onset asthma. Among subjects with early-onset asthma there were higher frequencies of allergic asthma (92.1 vs 76.4%), asthma familiarity (52.8 vs 42.8%), seasonal symptoms (51.3 vs 27.6%), active smoking habits (8.5 vs 4.4%) and u…

medicine.medical_specialtyPediatricsbusiness.industryOccupational riskOverweightmedicine.diseaseLower riskObesityrespiratory tract diseasesAtopyEpidemiologymedicinemedicine.symptombusinessOccupational asthmaAsthma6.1 Epidemiology
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Depression is associated with poor control of symptoms in asthma and rhinitis: A population-based study

2019

Abstract Background Although many studies have highlighted the link between asthma/rhinitis and depression, it is still unclear which characteristics of these diseases are associated with the risk of depression. We aimed to explore the relationship between depression and asthma or rhinitis in a representative sample of the Italian general population. Methods The data were collected in GEIRD, an Italian multicenter, population-based, multicase-control study. 2227 participants (age 21–86 years, female 50%) underwent standardized interviews, skin prick and lung function tests, and were divided into cases of current asthma (n = 528), rhinitis without asthma (n = 972), and controls (n = 727). Tw…

AdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyActivities of daily livingPopulationSettore MED/10 - Malattie Dell'Apparato RespiratorioPulmonary function testingAtopyYoung Adult03 medical and health sciences0302 clinical medicineAsthma controlInternal medicinemedicineHumans030212 general & internal medicineMedical prescriptioneducationAgedRhinitisAsthmaAged 80 and overeducation.field_of_studyAtopyDepressionbusiness.industryAnhedoniaGeneral populationMiddle Agedmedicine.diseaseAsthmaPatient Health QuestionnaireItaly030228 respiratory systemAsthma control; Atopy; Depression; General population; Rhinitis controlRhinitis controlFemalemedicine.symptombusinessRespiratory Medicine
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Real-world experience with dupilumab in severe asthma: One-year data from an italian named patient program

2021

Raffaele Campisi,1 Claudia Crimi,1 Santi Nolasco,2 Bianca Begh&amp;egrave;,3 Leonardo Antonicelli,4 Gabriella Guarnieri,5 Nicola Scichilone,6 Morena Porto,2 Luigi Macchia,7 Giulia Scioscia,8 Maria Pia Foschino Barbaro,8 Alberto Papi,9 Nunzio Crimi1,2 1Respiratory Medicine Unit, A.O.U. Policlinico &amp;ldquo;G. Rodolico -San Marco&amp;rdquo;, Catania, Italy; 2Department of Clinical and Experimental Medicine, Section of Respiratory Diseases, University of Catania, Catania, Italy; 3Respiratory Medicine Unit, Department of Medicine, University of Modena and Reggio Emilia, Modena, Italy; 4Allergy Unit, Department of Internal Medicine, Ancona University Hospital, Ancona, Italy; 5Department of Car…

severe asthmaPulmonary and Respiratory MedicineSevere asthmareal-worldmedicine.medical_specialtyTreatment responseSevere asthmaSocio-culturaleDupilumab Named Patient Program Oral corticosteroids Real-world Severe asthmaHypereosinophiliaDupilumaboral corticosteroidsSettore MED/10 - Malattie Dell'Apparato Respiratoriolaw.inventionNamed Patient Program dupilumab oral corticosteroids real-world severe asthma03 medical and health sciences0302 clinical medicineRandomized controlled triallawdupilumabInternal medicineOral corticosteroidsJournal of Asthma and AllergymedicineImmunology and Allergy0601 history and archaeologyOriginal Research060102 archaeologybusiness.industryRetrospective cohort study06 humanities and the artsRC581-607Named Patient ProgramEosinophilDupilumabmedicine.anatomical_structureReal-world030228 respiratory systemCohortImmunologic diseases. Allergymedicine.symptombusinessDupilumab; Named Patient Program; Oral corticosteroids; Real-world; Severe asthma
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Gastritis and gastroesophageal reflux disease are strongly associated with non-allergic nasal disorders

2021

AbstractBackgroundGastroesophageal reflux disease (GERD) has been reported to be significantly associated with chronic rhinosinusitis, but the strength of the association is still debated.AimsTo evaluate the strength of the association between gastritis/GERD and non-allergic rhinitis (NAR)/allergic rhinitis (AR)/sinusitis.MethodsWe investigated 2887 subjects aged 20–84 years, who underwent a clinical visit in seven Italian centres (Ancona, Palermo, Pavia, Terni, Sassari, Torino, Verona) within the study on Gene Environment Interactions in Respiratory Diseases, a population-based multicase-control study between 2008 and 2014. Subjects were asked if they had doctor-diagnosed “gastritis or sto…

MaleNon-allergic rhinitisGastroesophageal reflux diseaseGastroenterologyAllergic rhinitis0302 clinical medicinePrevalenceNon-allergic rhiniti030223 otorhinolaryngologySinusitisRhinitisAged 80 and overeducation.field_of_studyMiddle AgedGastrititItalyGastritisGastroesophageal RefluxFemalePublic HealthGastritismedicine.symptomResearch ArticleAdultPulmonary and Respiratory Medicinemedicine.medical_specialtyPopulationGastrititsSettore MED/10 - Malattie Dell'Apparato RespiratorioNOHiatal herniaGastritits Gastroesophageal refux disease Allergic rhinitis Non-allergic rhinitis SinusitisYoung Adult03 medical and health sciencesAllergic rhinitis; Gastritits; Gastroesophageal reflux disease; Non-allergic rhinitis; SinusitisInternal medicineAllergic rhinitimedicineHumansGastroesophageal refux diseaseSinusitiseducationAgedlcsh:RC705-779business.industrylcsh:Diseases of the respiratory systemmedicine.diseaseRhinitis AllergicSinusitidigestive system diseases030228 respiratory systemRelative riskChronic DiseaseGERDAllergic rhinitis; Gastritits; Gastroesophageal reflux disease; Non-allergic rhinitis; Sinusitis Public HealthNon-allergic rhinitisbusinessEsophagitis
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Relationship status and respiratory diseases: an analysis on a general population sample

2021

Background: Very few studies have examined whether marital/relationship status affects respiratory diseases. Objective: Assess the association of relationship status (Rstatus: domestic partnership/civil union/marriage, cohabitation with non-partners, being single) with current (CA) and past asthma (PA), allergic (AR) and non-allergic rhinitis (NAR), and chronic bronchitis (CB). Methods: Data were collected in the frame of GEIRD, a population-based, multicase-control survey. Among 2531 subjects (age 21–86, female 50%) who underwent standardized interviews, skin prick and lung function tests, 575 cases of CA, 268 cases of PA, 968 cases of AR, 462 cases of NAR, 265 cases of CB without airflow …

Chronic bronchitisCohabitationbusiness.industryConfoundingMedicineDomestic partnershipbusinessmedicine.diseaseLogistic regressionDemographyMultinomial logistic regressionPulmonary function testingAsthmaEpidemiology
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Asthma after consumption of snails in house-dust-mite-allergic patients: a case of IgE cross-reactivity

1996

A group of 28 patients from Italy was studied who had asthma after consumption of snail. All patients also had asthma and/or rhinitis caused by house-dust mite. RAST analyses confirmed the combined sensitization to snail and mite. In a few sera, IgE antibodies reactive with other foods of invertebrate origin (mussel and shrimp) were detected. RAST inhibition showed that most IgE antibodies against snail were cross-reactive with house-dust mite. In contrast, the mite RAST was not significantly inhibited by snail. This indicates that house-dust mite was the sensitizing agent. Immunoblot analyses revealed multiple bands in snail extract recognized by IgE. In contrast to what has been described…

House dust miteAllergyintegumentary systembiologymedicine.diagnostic_testRadioallergosorbent testfungiImmunologySnailImmunoglobulin Ebiology.organism_classificationmedicine.disease_causemedicine.diseaseCross-reactivityrespiratory tract diseasesAllergenimmune system diseasesbiology.animalparasitic diseasesImmunologybiology.proteinmedicineMiteImmunology and AllergyAllergy
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Long-term residential exposure to air pollution and risk of chronic respiratory diseases in Italy: The BIGEPI study

2023

: Long-term exposure to air pollution has adverse respiratory health effects. We investigated the cross-sectional relationship between residential exposure to air pollutants and the risk of suffering from chronic respiratory diseases in some Italian cities. In the BIGEPI project, we harmonised questionnaire data from two population-based studies conducted in 2007-2014. By combining self-reported diagnoses, symptoms and medication use, we identified cases of rhinitis (n = 965), asthma (n = 328), chronic bronchitis/chronic obstructive pulmonary disease (CB/COPD, n = 469), and controls (n = 2380) belonging to 13 cohorts from 8 Italian cities (Pavia, Turin, Verona, Terni, Pisa, Ancona, Palermo,…

Public healthEnvironmental EngineeringPublic health.EpidemiologySettore MED/10 - Malattie Dell'Apparato RespiratorioPollutionAsthmaAir quality; Asthma; Chronic bronchitis; Epidemiology; Public health; RhinitisChronic bronchitiChronic bronchitisAir qualityEnvironmental ChemistryWaste Management and DisposalRhinitis
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