6533b7d7fe1ef96bd1267a16
RESEARCH PRODUCT
Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases
Pietro PirinaPierpaolo MarchettiGiulia SquillaciotiElia PiccinnoGiuseppe VerlatoSalvatore BattagliaAmelia GrossoAlessandro MarconGiancarlo PesceMarcello FerrariLucia CazzolettiLeonardo Antonicellisubject
MaleLUNG-DISEASEChronic bronchitisPulmonologyEpidemiologyBlood PressureCardiovascular Medicine030204 cardiovascular system & hematologyVascular Medicine[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tractCohort StudiesPulmonary Disease Chronic Obstructive0302 clinical medicineRisk FactorsMedicine and Health SciencesOdds Ratiochronic bronchitiLungRhinitisAged 80 and overeducation.field_of_studyAlcohol ConsumptionMultidisciplinaryQRHeartMiddle AgedCardiovascular diseaseCBRespiratory Function Tests3. Good healthPREVALENCE[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemBronchitis ChronicALLERGIC RHINITISINTERMITTENT CLAUDICATIONCardiovascular DiseasesHypertensionBronchitisMedicinechronic bronchitisFemaleAnatomymedicine.symptomResearch ArticleAdultmedicine.medical_specialtySciencePopulationbody mass indexSettore MED/10 - Malattie Dell'Apparato RespiratorioDIAGNOSISelderlychronic obstructive pulmonary diseaseYoung Adult03 medical and health sciencesHeart disorderBMI[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemInternal medicineConfidence IntervalsmedicineHumansCOPDCORONARY-HEART-DISEASEBronchitiseducationNutritionAgedAsthmaCORONARY-HEART-DISEASE; ALLERGIC RHINITIS; INTERMITTENT CLAUDICATION; MYOCARDIAL-INFARCTION; MUCUS HYPERSECRETION; CIGARETTE-SMOKING; LUNG-DISEASE; DIAGNOSIS; ATHEROSCLEROSIS; PREVALENCEbusiness.industryBiology and Life SciencesOdds ratioRhinologyasthmamedicine.diseaseIntermittent claudicationDietOtorhinolaryngology030228 respiratory systemMYOCARDIAL-INFARCTIONATHEROSCLEROSISMUCUS HYPERSECRETION[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologieMedical Risk FactorsCase-Control StudiesRelative riskNasal DiseasesCardiovascular Anatomy[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieCIGARETTE-SMOKINGbusinessBMI body mass index; CB chronic bronchitis; COPD chronic obstructive pulmonary disease;description
Background and objectives Cardiovascular and respiratory diseases can frequently coexist. Understanding their link may improve disease management. We aimed at assessing the associations of chronic bronchitis (CB), asthma and rhinitis with cardiovascular diseases and risk factors in the general population. Methods We used data collected in the Gene Environment Interactions in Respiratory Diseases study, an Italian multicentre, multicase-control study. Among 2463 participants (age 21–86, female 50%) who underwent standardized interviews, skin prick and lung function tests, we identified 254 cases of CB without airflow obstruction, 418 cases of asthma without CB, 959 cases of rhinitis alone, and 832 controls. The associations of respiratory diseases with reported cardiovascular risk factors (lifestyles, hypertension, dyslipidaemia), heart disorders (myocardial infarction, coronary thrombosis, angina, aorta or heart surgery) and intermittent claudication were estimated through relative risk ratios (RRR) by multinomial logistic regression models. Results Compared to controls, CB cases were more likely to be heavy smokers, alcohol consumers, physically inactive, and to suffer from hypertension or dyslipidaemia; rhinitis cases were less obese but more likely to have hypertension. Asthma was significantly associated with current smoking. After adjusting for cardiovascular risk factors, heart disorders were associated with CB (RRR[95%CI]: 1.58[1.12–2.22]) and rhinitis (1.35[0.98–1.85]) and intermittent claudication was associated with CB (3.43[2.52–4.67]), asthma (1.51[1.04–2.21]) and rhinitis (2.03[1.34–3.07]). Conclusions CB, asthma and rhinitis were associated with cardiovascular risk factors and diseases. In particular, CB shared with cardiovascular diseases almost all risk factors and was strongly associated with a higher risk of heart disorders and intermittent claudication.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-11-07 |