0000000000025107
AUTHOR
A. Marquina-vila
Detección del virus del papiloma humano en muestras de cáncer cutáneo no melanoma y piel sana perilesional en pacientes trasplantados renales y pacientes inmunocompetentes
Antecedentes La influencia del virus del papiloma humano (VPH) en el desarrollo de carcinoma cutaneo no melanoma es un tema controvertido. VPH-s es el genero mas frecuente relacionado con el desarrollo de cancer de piel. Objetivos Analizar la prevalencia y espectro de los tipos de VPH presentes en piel tumoral y piel sana perilesional en pacientes inmunodeprimidos y pacientes inmunocompetentes, asi como evaluar la influencia de diferentes factores clinicos en la prevalencia del VPH en cancer de piel. Metodos Se determino la presencia de VPH en 120 muestras mediante PCR nested y posterior secuenciacion. Se tomo biopsia de piel de 30 pacientes trasplantados renales y de 30 pacientes inmunocom…
La técnica del ganglio centinela en pacientes con melanoma
Resumen Introduccion y objetivos Actualmente existe un aumento mundial de la incidencia de melanoma. Su pronostico depende entre otros factores de la existencia de metastasis en los ganglios linfaticos regionales. La realizacion de la biopsia del ganglio centinela persigue la identificacion de metastasis ganglionares subclinicas como factor pronostico de la enfermedad. El presente estudio tiene por objetivo estudiar las diferencias entre los pacientes con melanoma, positivos y negativos a la biopsia del ganglio centinela, y analizar el impacto de esta tecnica en su pronostico. Material y metodos Se realizo biopsia del ganglio centinela a los pacientes con melanomas de espesor Breslow ≥1 mm …
Carcinoma epidermoide cutáneo: definición de sus características clínico-patológicas y factores de riesgo asociados en un estudio observacional de 118 pacientes
Resumen Introduccion y objetivo En la ultima edicion del manual de la American Joint Committee on Cancer (AJCC) se modifico la estadificacion para el carcinoma epidermoide cutaneo (CEC), introduciendo caracteristicas tumorales de alto riesgo que definen el estadio tumoral (T), con el proposito de identificar aquellos tumores con mayor riesgo de metastasis. Nuestro objetivo fue definir las caracteristicas asociadas al CEC que cumplia criterios de alto riesgo definidos por la AJCC para ser estadio T2. Pacientes y metodo Estudio observacional analitico tipo casos-casos de 18 meses donde se han incluido pacientes con diagnostico de CEC. Se recogieron datos clinicos, antropometricos y tumorales.…
Detection of Human Papillomavirus in Nonmelanoma Skin Cancer Lesions and Healthy Perilesional Skin in Kidney Transplant Recipients and Immunocompetent Patients
Abstract Background The influence of human papillomavirus (HPV) on the development of nonmelanoma skin cancer (NMSC) is a topic of debate. HPV types from the beta genus (HPV-β) have been most frequently associated with the development of skin cancer. Objectives To analyze the prevalence and range of HPV types in NMSC lesions and healthy perilesional skin in immunodepressed and immunocompetent patients and to evaluate the influence of various clinical factors on the prevalence of HPV in skin cancer. Methods Nested polymerase chain reaction and sequencing were used to detect HPV in 120 NMSC samples obtained by biopsy from 30 kidney transplant recipients and 30 immunocompetent patients. In all…
Serum 25-hydroxyvitamin D levels in patients with cutaneous lupus erythematosus in a Mediterranean region
Low vitamin D levels have been found in patients with autoimmune diseases, including type I diabetes, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus. The main source of vitamin D is exposure to sunlight, but the same solar radiation is known to exacerbate lupus erythematosus. We investigated the prevalence of vitamin D insufficiency in patients with cutaneous lupus erythematosus (CLE). We designed a cross-sectional study including 55 patients with CLE to measure their serum 25-hydroxyvitamin D (25(OH)D) by chemiluminescence immunoassay and compare it with a control group consisting of 37 healthy sex and age-matched subjects recruited from the patients' relatives a…
Sentinel Lymph Node Biopsy in Patients With Melanoma
Abstract Introduction and objectives The incidence of melanoma is currently increasing worldwide. One of the factors influencing disease prognosis is the presence of regional lymph node metastases. Sentinel lymph node biopsy attempts to identify subclinical lymph node metastasis as a prognostic factor in the disease. The aim of this study was to analyze differences between patients with melanoma for whom positive or negative results were obtained in sentinel lymph node biopsy and to assess the impact of the technique on disease prognosis. Material and methods Sentinel lymph node biopsy was carried out in patients with melanoma of the following characteristics: Breslow thickness ≥1mm, Breslo…
Vitamin D and cutaneous lupus erythematosus: effect of vitamin D replacement on disease severity.
Background The main vitamin D source is exposure to ultraviolet radiation, which aggravates cutaneous lupus erythematosus (CLE). Objectives The aims of this study were to identify variables associated with lower serum 25-hydroxyvitamin D [25(OH)D] levels in CLE patients and assess the effect of vitamin D restoration on disease severity. Methods Vitamin D status in 60 CLE patients and 117 apparently healthy subjects was compared. We recommended oral vitamin D3 to 27 CLE patients. After one year of treatment, changes in disease severity were assessed and compared to 25 untreated CLE patients. Disease severity was measured by the Cutaneous Lupus Erythematosus Disease Area and Severity Index (C…
Papel de los nuevos agentes inmunosupresores en el cáncer cutáneo no melanoma en pacientes trasplantados renales
Resumen Introduccion El cancer de piel no melanoma (CCNM) es la neoplasia maligna que se presenta con mas frecuencia despues de un trasplante de organo solido. La etiologia del CCNM tras el trasplante es multifactorial. Objetivos Analizar la relacion entre los nuevos agentes inmunosupresores y la aparicion de CCNM en pacientes trasplantados renales. Metodo Estudio observacional. Se examinaron una combinacion de datos retrospectivos y prospectivos. Incluimos en el estudio 289 pacientes que habian recibido trasplante renal desde enero de 1996 hasta diciembre de 2010 en el Hospital Universitario Doctor Peset de Valencia. Resultados Tras una mediana de seguimiento de 72 meses 73 pacientes (25,2…
The Role of New Immunosuppressive Drugs in Nonmelanoma Skin Cancer in Renal Transplant Recipients
Abstract Introduction Nonmelanoma skin cancer (NMSC) is the most common malignancy in patients who have received a solid organ transplant. Multiple factors are involved in the onset of posttransplant NMSC. Objectives To analyze the relationship between new immunosuppressive drugs and the onset of NMSC in renal transplant recipients. Method This was a combined retrospective and prospective observational study in which we studied 289 patients who received a kidney transplant between January 1996 and December 2010 at Hospital Universitario Doctor Peset in Valencia, Spain. Results Seventy-three patients (25.2%) developed 162 NMSCs over a median follow-up of 72 months. There were no statisticall…
Squamous Cell Carcinoma: Clinical and Pathological Features and Associated Risk Factors in an Observational Study of 118 Patients
Background and objective: In the latest edition of its cancer staging manual, the American JointCommittee on Cancer (AJCC) revised the criteria for staging squamous cell carcinoma (SCC) by introducing high-risk tumor features to define tumor stage (T) and help to identify tumors with a higher risk of metastasis. The aim of this study was to investigate the characteristics associated with SCC meeting the high-risk criteria defined by the AJCC for T2 lesions. Patients and method: We performed a case-case observational study in which patients with SCC were included over a period of 18 months. We collected clinical, anthropometric, and tumor data, and analyzed these using PASW Statistics (SPSS)…