The “mode” of lymphocyte extravasation through HEV of Peyer's patches and its role in normal homing and inflammation

The mode of lymphocyte transendothelial migration in the postcapillary high endothelial venules (HEVs) of Peyer's patches during normal homing and acute inflammation in the guinea pig was studied. It is common opinion that the lymphocyte transendothelial passage from the blood stream into the extravasal lymphoid tissue calls for a multistep process of endothelial and lymphocyte molecules favoring tethering, rolling, activation, arrest and its firm adhesion to the endothelial luminal surface. Ultrastructural serial pictures and the three-dimensional reconstruction of HEVs with lymphocytes during different moments of their transmigration through the endothelial wall enabled us to demonstrate …

FINE STRUCTURE OF THE ABSORBING LYMPHATIC VESSEL AND INTRAVASATION MODALITY OF THE CANCER CELL

The topografic distribution and the fine structure of the tumor-associated absorbing lymphatic vessel in the B16 Melanoma and T84 adenocarcinoma subcutaneous tumor mass of nude mice and in adenocarcinoma mouse prostate in transgenic mice were studied to demonstrate the modality of the cancer cell transendothelial migration and the role of the lymphatic pathway in the metastatic diffusion. Furthermore, the structural characteristics of the lymphatic vascular system canalisation, that allow to discriminate between the vessels with high absorbent capacity, distinctive of the mucous and submucous network and vessels with lymph flow and conduction function (precollectors, pre- and postlymph noda…

On the lymphocyte transendothelial migration at the level of absorbing lymphatic vessel of thymus-dependent lymphoid areas of Peyer's patches

Seasonal features of lymphocyte extravasation through bthe lymph nodal HEVS

On the absorbent peripheral lymphatic vessel (ALPA) vessel in some experimental toumors

Chronic administration of green tea extract to TRAMP mice induces the collapse of Golgi apparatus in prostate secretory cells and results in alterations of protein post-translational processing.

Considering its long latency, prostate cancer (PCa) represents an ideal target for chemoprevention strategies. Green tea extract (GTE) has been proved to be one of the most promising natural substances capable of inhibiting PCa progression in animal models (transgenic adenocarcinoma of mouse prostate), as well as in humans. However, the cellular targets of the GTE action are mostly unknown. The main objective of this work was to investigate whether the endoplasmic reticulum (ER) and the Golgi apparatus (GA), known to be actively involved in sensing stress stimuli and initiating and propagating cell death signalling, may represent the subcellular targets of GTE action. To this end, 42 TRAMP …

New route of lymphocyte diapedesis through High endothelial venules (HEVs) in peripheral and mucosa-associated lymphoid tissue