0000000000026229

AUTHOR

Antonella Ballacchino

showing 6 related works from this author

Notch-1 decreased expression contributes to leptin receptor downregulation in nasal epithelium from allergic turbinates

2019

Abstract BACKGROUND: Allergic rhinitis is characterized by a remodeling of nasal epithelium. Since the Notch and TGF-β signaling pathways are known to be involved in cell differentiation and remodeling processes and leptin adipokine has already been identified as a marker for homeostasis in human bronchial and nasal epithelial cells of asthmatics, roles played by these pathways have been investigated for chronic allergic rhinitis. METHODS: The leptin/leptin receptor expression has been investigated in a study with 40 biopsies from allergic (AR, n = 18) and non-allergic (C, n = 22) inferior turbinates, using immunohistochemistry, immunofluorescence staining and RT-PCR. In addition, extracts …

0301 basic medicineAdultLeptinMalemedicine.medical_specialtyBiopsyPrimary Cell CultureAdipokineTurbinatesCell LineTransforming Growth Factor beta103 medical and health sciences0302 clinical medicineDownregulation and upregulationInternal medicinemedicineHomeostasisHumansRNA MessengerReceptor Notch1610 Medicine & healthReceptorMolecular BiologyNotch 1Leptin receptorChemistryLeptindigestive oral and skin physiologyEpithelial CellsMiddle AgedRhinitis AllergicAllergic rhinitis Epithelium Leptin NotchEpitheliumNasal Mucosa030104 developmental biologyEndocrinologymedicine.anatomical_structureGene Expression Regulation030220 oncology & carcinogenesisCase-Control StudiesMolecular MedicineReceptors LeptinFemaleSignal transductionSignal Transduction
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Fluticasone furoate maintains epithelial homeostasis via leptin/leptin receptor pathway in nasal cells

2014

Leptin is involved in the lung epithelial homeostasis. Its role in the nasal tract is largely unknown. Allergic rhinitis (AR) is induced by the allergen exposure leading to consequential structural abnormalities in the nasal epithelium. Topical corticosteroids are recommended as first-line therapy in AR. Parietaria pollen is one of the most important allergenic sources in the southern Europe. In vitro, in human nasal epithelial cell line RPMI 2650, we aimed to determine whether allergen stimulation acts on leptin/leptin receptor pathway and how fluticasone furoate (FF) influences this pathway. The effects of the major allergen recombinant Par j 1 (rPar j 1), of FF, of leptin, and of TGF-b1 …

LeptinSTAT3 Transcription Factormedicine.medical_specialtyAllergic rhinitis Epithelium Fluticasone furoate Leptin rPar j 1Clinical BiochemistryStimulationSettore MED/10 - Malattie Dell'Apparato RespiratorioBiologymedicine.disease_causeSettore BIO/09 - FisiologiaFluticasone propionateCell LineTransforming Growth Factor beta1AllergenWestern blotAllergic rhinitis Epithelium Fluticasone furoate Leptin rPar j 1Internal medicinemedicineHomeostasisHumansMolecular BiologyCell ProliferationPlant ProteinsLeptin receptormedicine.diagnostic_testCell growthLeptindigestive oral and skin physiologyCell BiologyGeneral MedicineAllergensRhinitis AllergicEpitheliumRecombinant ProteinsAndrostadienesNasal MucosaProtein TransportEndocrinologymedicine.anatomical_structureReceptors Leptinhormones hormone substitutes and hormone antagonistsmedicine.drugSignal Transduction
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Impairment of leptin/leptin receptor pathway in nasal epithelium from allergic turbinates

2016

BACKGROUND: Allergic rhinitis (AR) is characterized by a remodeling of nasal epithelium. Leptin adipokine has been already identified as a marker of homeostasis in human bronchial epithelial of asthmatics. TGF-β is a multi-functional cytokine and conflicting findings exist regarding its role in the remodeling responses of the upper airways in allergic rhinitis. OBJECTIVE: We sought to investigate ex-vivo the expression of leptin/leptin receptor pathway and TGF-β in human nasal epithelium. METHODS: 41 biopsies of inferior turbinates obtained from allergic patients with AR (A, n = 20) and from healthy control subjects (C, n = 21) were analyzed for leptin/leptin receptor and for TGF-β 1, 2, 3 …

medicine.medical_specialtyLeptin receptorbusiness.industryLeptinmedicine.medical_treatmentdigestive oral and skin physiologyAdipokineEpitheliummedicine.anatomical_structureEndocrinologyCytokineInternal medicineImmunologyMedicineImmunohistochemistrybusinessReceptorhormones hormone substitutes and hormone antagonistsHomeostasis3.2 Airway Cell Biology and Immunopathology
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Audiologic profile of OSAS and simple snoring patients: the effect of chronic nocturnal intermittent hypoxia on auditory function

2016

The objective of this work was to study the effect of nocturnal intermittent hypoxia on auditory function of simple snoring patients and subjects affected by OSAS; we compared the audiologic profile with the severity of OSAS to detect early signs of cochlear damage. One hundred-sixty patients underwent overnight polysomnography, micro-otoscopy, multi-frequency audiometry, acufenometry, TEOAE recording and d-ROMs test. All subjects were divided in four groups, based on presence/absence of AHI (simple snoring without OSAS, mild OSAS, moderate OSAS, severe OSAS). Sixty (37.5 %) patients were not affected by OSAS, 58 (36.25 %) presented a mild OSAS, 18 (11.25 %) a moderate OSAS and 24 (15 %) a …

TinnituMaleOtoscopyPolysomnographyAudiologySeverity of Illness IndexTinnitus0302 clinical medicineHypoxia030223 otorhinolaryngologySleep Apnea Obstructivemedicine.diagnostic_testOtorhinolaryngology2734 Pathology and Forensic MedicineIntermittent hypoxiaGeneral MedicineMiddle AgedSettore MED/32 - AudiologiaSettore MED/31 - OtorinolaringoiatriaCardiologyFemaleNeurosurgerymedicine.symptomHearing loAdultMulti-frequency audiometrymedicine.medical_specialtyHearing lossPolysomnography03 medical and health sciencesAudiometrystomatognathic systemInternal medicineSeverity of illnessTEOAEotorhinolaryngologic diseasesmedicineHumansHearing Lossbusiness.industrySnoringHearing loss; Multi-frequency audiometry; OSAS; TEOAE; Tinnitus; Otorhinolaryngology2734 Pathology and Forensic MedicineOSASAuditory ThresholdHypoxia (medical)nervous system diseasesrespiratory tract diseases030228 respiratory systemOtorhinolaryngologyAudiometrybusinessTinnitusEuropean Archives of Oto-Rhino-Laryngology
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Speech perception outcomes after cochlear implantation in prelingually deaf infants: The Western Sicily experience

2013

Objectives: To describe audiometric characteristics and speech perception performances of prelingually deaf Sicilian children after cochlear implantation; to identify the influence of cochlear implant (CI) user and family's characteristics on speech recognition and intelligibility outcomes. Methods: Twenty-eight infants with a congenital or acquired hearing impairment and implanted before the 3rd year of life were studied; all children suffered from bilateral sensorineural hearing loss (SNHL) with evidence of lack of hearing aids benefit and no evidence of intellectual disability. The study of the main characteristics associated with CI user and family's profile was performed with a clinica…

MaleCochlear implant Deaf children Sensorineural hearing loss Speech perception Speech intelligibilitymedicine.medical_specialtySpeech perceptionHearing lossmedicine.medical_treatmentHearing Loss SensorineuralIntelligibility (communication)AudiologyDeafnessAudiometryCochlear implantSurveys and QuestionnairesIntellectual disabilityotorhinolaryngologic diseasesmedicineHumansSicilymedicine.diagnostic_testbusiness.industrySpeech IntelligibilityInfantGeneral Medicinemedicine.diseaseCochlear ImplantationCochlear ImplantsTreatment OutcomeOtorhinolaryngologyPediatrics Perinatology and Child HealthCohortSpeech PerceptionSensorineural hearing lossFemaleAudiometrymedicine.symptombusiness
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Increased expression of IL-19 in the epithelium of patients with chronic rhinosinusitis and nasal polyps.

2012

Background : Chronic rhinosinusitis (CRS) is an inflammation of the nose and of the paranasal sinuses. The involvement of the respiratory epithelium in the mechanisms of CRS is poorly understood. Aims : Among proteins expressed by nasal epithelial cells in CRS, IL-19 may have key functions. We here aimed to determine the expression and regulation of IL-19. Methods : Nasal biopsies from normal subjects (n = 12), subjects with CRS but without nasal polyps (NP) (CRSsNP, n = 12) and with CRS with NP (CRSwNP, n = 15) were collected. Human Asthma Gene Array and real-time PCR were used to evaluate gene expression, western blot analysis and immunohistochemistry for protein expression. Results for I…

AdultMalePathologymedicine.medical_specialtyAdolescentImmunologyGene ExpressionMucous membrane of noseYoung AdultInterleukin 20Nasal Polypsotorhinolaryngologic diseasesImmunology and AllergyMedicineHumansNasal polypsRNA MessengerSinusitisSinusitisAsthma inflammation nasal polyps rhinitisRhinitisbusiness.industryGene Expression ProfilingInterleukinsEpithelial CellsMiddle Agedmedicine.diseaseEpitheliumGene expression profilingNasal Mucosamedicine.anatomical_structureParanasal sinusesKi-67 AntigenImmunologyChronic DiseaseRespiratory epitheliumFemalebusinessAllergy
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