0000000000033477
AUTHOR
G. Petrisor
Designing Medical Devices Based on Silicon Polymeric Material with Controlled Release of Local Anesthetics
The drug delivery systems that are the object of this article take the form of a polymer matrix made of silicone containing a drug. These devices can be used as patches for local dermal applications releasing the drug in a controlled manner. The model active agent, lidocaine hydrochloride was chosen from the range of local anesthetics. When the drug is restricted to the surface, it is released more rapidly than when it is allowed to spread evenly throughout the silicon structure. When hydrophilic polymers such as PVA and HEC are mixed in with the lidocaine hydrochloride and deposited on the surface of the polymer matrix, we observed that the burst effect was eliminated without modifying the…
In VitroRelease of Local Anaesthetic and Anti-Inflammatory Drugs from Crosslinked Collagen Based Device
The drug delivery systems that are the object of this article take the form of a hydrophilic matrix (collagen or crosslinked collagen) containing a drug. These devices can be used as The model active agents, were chosen from the range of local anaesthetics (lidocaine hydrochloride), anti-inflammatory (diclofenac sodium salt) and antioxydant (caffeic acid). Whatever the drug affinity for water, in the first time of the experiments, the release appears to be systematically delayed when the matrix is crosslinked. For lidocaine hydrochloride based systems, as the amount of drug increases in the matrix, the high gap concentration between the matrix and the buffer solution promote the diffusion a…