Familial hypobetalipoproteinemia: Analysis by next generation sequencing and identification of a novel frameshift mutation in the apoB gene

Measurement of W-pair production in $e^{+}e^{-}$ collisions at centre-of-mass energies from 183 to 209 GeV

The W + W- production cross section is measured from a data sample corresponding to a total integrated luminosity of 683 pb-1, collected by the ALEPH experiment at LEP at centre-of-mass energies from 183 to 209 GeV. Individual cross sections for the different topologies arising from W decays into leptons or hadrons, as well as the total W-pair cross section are given at eight centre-of-mass energies. The results are found to be in agreement with recently developed Standard Model calculations at the one percent level. The hadronic branching fraction of the W boson is measured to be B(W→qq¯) = 67.13 ± 0.37(stat.) ± 0.15(syst.)%, from which the CKM matrix element |\ensuremathVcs| is determined…

Rapid Identification by MALDITOF of Neisseria elongata Subspecies nitroreducens in an Endocarditis Case

Abstract Background: Neisseria elongata subspecies nitroreducens is considered to be an important pathogen responsible for infective endocarditis, even if it is infrequently reported. We report the first case of endocarditis in Italy due to N. elongata subsp. nitroreducens. Case presentation: The infection occurs in a 40-year-old male affected by Marfan syndrome with a prosthetic aortic valve. The patient had had a fever for a week which had been resistant to antibiotic therapy. Conclusion: we propose a correct and rapid identification of Neisseria elongata subspecies nitroreducens by mass spectrometry directly from the positive blood culture. The rapidly identification obtained by MALDI-TO…

Metabolic disturbances and risk of cancer in the 25 years follow-up of the “Ventimiglia Heart Study” epidemiological project

Carotid plaque detection improves the predictve value of CHA2DS2-VASc score in patients with non-valvular atrial fibrilation: The ARAPACIS Study

Abstract Background and aims Vascular disease (VD), as assessed by history of myocardial infarction or peripheral artery disease or aortic plaque, increases stroke risk in atrial fibrillation (AF), and is a component of risk assessment using the CHA 2 DS 2 -VASc score. We investigated if systemic atherosclerosis as detected by ultrasound carotid plaque (CP) could improve the predictive value of the CHA 2 DS 2 -VASc score. Methods We analysed data from the ARAPACIS study, an observational study including 2027 Italian patients with non-valvular AF, in whom CP was detected using Doppler Ultrasonography. Results VD was reported in 351 (17.3%) patients while CP was detected in 16.6% patients. Ad…

Mutation in candidate genes account for a small minority of hypobetalipoproteinemias and NGS analysis support polygenicity in mutation-negative patients

Search for neutral Higgs bosons decaying into four taus at LEP2

A search for the production and non-standard decay of a Higgs boson, h, into four taus through intermediate pseudoscalars, a, is conducted on 683 pb-1 of data collected by the ALEPH experiment at centre-of-mass energies from 183 to 209 GeV. No excess of events above background is observed, and exclusion limits are placed on the combined production cross section times branching ratio, β2 = σ(e+e -→Zh)/σSM(e+e-→Zh) ×B(h→aa)×B(a→τ+τ-) 2. For mh 1 is excluded at the 95% confidence level.

L'aztreonam Nelle Infezioni Delle Vie Urinarie

Measurement of Z-pair production in e(+)e(-) collisions and constraints on anomalous neutral gauge couplings

The ZZ production cross section is measured from a data sample corresponding to a total integrated luminosity of 452 pb−1, collected by the ALEPH experiment at LEP at centre-of-mass energies from 192 to 209 GeV. Individual cross sections, extracted at six centre-of-mass energies, are found to be in agreement with Standard Model calculations. The results are used to set limits on anomalous neutral gauge couplings. The ZZ production cross section is measured from a data sample corresponding to a total integrated luminosity of 452 pb−1 , collected by the ALEPH experiment at LEP at centre-of-mass energies from 192 to 209 GeV. Individual cross sections, extracted at six centre-of-mass energies, …

Molecular epidemiology of KPC-producing Klebsiella pneumoniae from invasive infections in Italy: Increasing diversity with predominance of the ST512 clade II sublineage

Objectives The spread of carbapenem-resistant Enterobacteriaceae (CRE) represents one of the most worrisome problems for clinical medicine worldwide. In Italy, the Antibiotic-Resistance-Istituto Superiore di Sanita surveillance network, in collaboration with the Committee for Antimicrobial Agents of the Italian Society of Clinical Microbiologists, promoted a study to investigate the carbapenem-resistance mechanisms, clonal relatedness and capsular typing of a recent collection of carbapenem-resistant Klebsiella pneumoniae (CR-KP). Methods A total of 17 laboratories distributed across Italy collected all consecutive non-replicate CR-KP isolated from invasive infections during two different s…

Factors leading to dissemination of cutaneous anthrax: an international ID-IRI study

Background: Although anthrax is a rare zoonotic infection, it still causes significant mortality and morbidity. In this multicenter study, which is the largest anthrax case series ever reported, we aimed to describe the factors leading to dissemination of cutaneous anthrax.Methods: Adult patients with cutaneous anthrax from 16 referral centers were pooled. The study had a retrospective design, and included patients treated between January 1, 1990 and December 1, 2019. Probable, and confirmed cases based upon CDC anthrax 2018 case definition were included in the study. A descriptive statistical analysis was performed for all variables.Results: A total of 141 cutaneous anthrax patients were i…

Antibiotic resistance profiles in Helicobacter pylori strains isolated in Sicily (Italy)

Biofilm production in Staphylococcus epidermidis strains, isolated from the skin of hospitalized patients: genetic and phenotypic characteristics.

A major virulence factor of Staphylococcus epidermidis is its ability to form biofilms, permitting it to adhere to a surface and, in turn, to form a mucoid layer on polymer surfaces. Multiple factors have been found to influence bacterial attachment. Currently, this bacterium is commonly associated with hospital infections as a consequence of its ability to colonize, albeit accidentally, medical devices. This study investigated the genetic and phenotypic formation of biofilm in 105 S. epidermidis strains isolated from the skin of hospitalized patients. Fifty-eight of these patients were positive for the mecA gene (MRSE) and 47 were found to be negative (MSSE). Genetic characterizations were…

Body composition of individuals with polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is one of the principle forms of hyperandrogenism that affects women of reproductive age. Few studies have evaluated the body composition of patients with PCOS being based mainly on an evaluation of the quantity and distribution of the fat mass. Objectives: to evaluate the body composition of patients affected by PCOS and to establish the hormonal factors that determine possible differences in body composition compared with healthy women. Methods: 110 Caucasian women affected by clinical hyperandrogenism and/or irregular menstrual periods were included in the study; the control group was made up of 90 healthy Caucasian women, of reproductive age, without hyp…

Branching Ratios and Spectral Functions of $\tau$ Decays: final ALEPH measurements and physics implications

The full LEP-1 data set collected with the ALEPH detector at the $Z$ pole during 1991-1995 is analysed in order to measure the $\tau$ decay branching fractions. Extensive systematic studies are performed, in order to match the large statistics of the data sample corresponding to over 300 000 measured and identified $\tau$ decays. Branching fractions are obtained for the two leptonic channels and eleven hadronic channels defined by their respective numbers of charged particles and $\pi^0$'s. Using previously published ALEPH results on final states with charged and neutral kaons, corrections are applied to the hadronic channels to derive branching ratios for exclusive final states without kao…

Absolute Lower Limits on the Masses of Selectrons and Sneutrinos in the MSSM

The results of searches for selectrons, charginos and neutralinos performed with the data collected by the ALEPH detector at LEP at centre-of-mass energies up to 209 GeV are interpreted in the framework of the Minimal Supersymmetric extension of the Standard Model with R-parity conservation. Under the assumptions of gaugino and sfermion mass unification and no sfermion mixing, an absolute lower limit of 73 GeV/c2 is set on the mass of the lighter selectron at the 95% confidence level. Similarly, limits on the masses of the heavier selectron and of the sneutrino are set at 107 and 84 GeV/c2, respectively. Additional constraints are derived from the results of the searches for Higgs bosons. T…

Identification Of P.Leu167Del Apoe Gene Mutation By Next Generation Sequencing In A Large Hypercholesterolemic Family

Constraints on anomalous QGC's in $e^{+}e^{-}$ interactions from 183 to 209 GeV

The acoplanar photon pairs produced in the reaction e+ e- --> nu nubar gamma gamma are analysed in the 700 inverse nanobarns of data collected by the ALEPH detector at centre-of-mass energies between 183 and 209 GeV. No deviation from the Standard Model predictions is seen in any of the distributions examined. The resulting 95% C.L. limits set on the anomalous QGC's, az_0, az_c, aw_0 and aw_c, are -0.012 GeV**-2 < az_0/Lambda**2 < +0.019 GeV**-2, -0.041 GeV**-2 < az_c/Lambda**2 < +0.044 GeV**-2, -0.060 GeV**-2 < aw_0/Lambda**2 < +0.055 GeV**-2, -0.099 GeV**-2 < aw_c/Lambda**2 < +0.093 GeV**-2, where Lambda is the energy scale of the new Physics responsible for the anomalous couplings.

Inclusive production of the η and ω mesons in Z decays, and the muonic branching ratio of the ω

AbstractThe inclusive production of the η and ω(782) mesons is measured in the π+π−π0 decay mode in hadronic Z decays and compared to model predictions. The analysis is based on 4 million hadronic Z decays recorded by the ALEPH detector between 1991 and 1995. The η production rate for xp=pmeson/pbeam>0.10 is found to be 0.355±0.011stat±0.024sys per event, and the ω production rate for xp>0.05 is measured as 0.585±0.019stat±0.033sys per event. The branching ratio for ω→μ+μ− is investigated. A total of 18.1±5.9 events are observed, from which the muonic branching ratio is measured for the first time to be BR(ω→μ+μ−)=(9.0±2.9stat±1.1sys)×10−5.

Assessment of humoral and cell-mediated immunity against Bordetella pertussis in adolescent, adult, and senior subjects in Italy

SUMMARYHumoral and cell-mediated immunity (CMI) againstB. pertussiswas assessed in a sample of adolescent, adult and senior subjects distributed in five different geographical areas in Italy. Most (99·1%) subjects had IgG anti-pertussis toxin (PT) antibodies exceeding the minimum detection level [⩾2 ELISA units (EU)/ml]. There were no significant differences between the genders; 6·2% samples recorded titres ⩾100 EU/ml. CMI was positive [stimulation index (SI) ⩾5] against PT in 39·0% of all samples. This study suggests thatB. pertussiscontinues to circulate in age groups that have been previously considered to be uninvolved in the circulation of this pathogen and that adolescent and adult pe…

REVISITING ANTHROPOZOONOSES IN THE MEDITERRANEAN BASIN. A SINGLE-CENTRE PERSPECTIVE. A SOUTHERN ITALIAN EXPERIENCE

Zoonoses, often better defined with the term anthropozoonoses, are diseases that can be transmitted to humans either by direct contact with animals or through arthropod vector intervention. Microbial interaction between humans and animals constitutes an important public health challenge, particularly in the Mediterranean basin. The main reasons this challenge is still relevant today include the phenomenon of migration, of both humans and animals, and climate change, which tend to alter the geographical distribution of zoonosis or the zoonotic agent, as well as the distribution range of potential vectors. The Mediterranean area seems to be affected by plentiful and widely distributed zoonose…

Helicobacter pylori and epstein–barr co-infection in gastric disease

The incidence of gastrointestinal diseases and in particular gastric cancer (GC) is high worldwide. Over the last few years, numerous studies have speculated that Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV) can be correlated with gastric cancerogenesis. Virulence factors of H. pylori can contribute to the variability of clinical outcomes: among the most important virulence factors is the pathogenicity island (CagPAI), vacA and oipA gene. EBV infection usually persists in B cells and induces an inflammatory reaction in cooperation with H. pylori. In Sicily, H. pylori and EBV infections are particularly prevalent, and to our knowledge no study has addressed this yet. The aim …

Infezioni Delle Vie Urinarie: Germi responsabili e chemioresistenza negli anni 1978–1983

The seroepidemiology of Bordetella pertussis infection in Western Europe.

High titres of pertussis toxin (PT) antibody have been shown to be predictive of recent infection with Bordetella pertussis. The seroprevalence of standardized anti-PT antibody was determined in six Western European countries between 1994 and 1998 and related to historical surveillance and vaccine programme data. Standardized anti-PT titres were calculated for a series of whole-cell and acellular pertussis vaccine trials. For the serological surveys, high-titre sera (&gt;125 units/ml) were distributed throughout all age groups in both high- (&gt;90%) and low-coverage (&lt;90%) countries. High-titre sera were more likely in infants in countries using high-titre-producing vaccines in their pr…

Rapidly growing mycobacteria in TB/HIV co-infection: a report of two cases focusing on difficulties in diagnosis and management.

Recent reports indicate an increase in rates of infection and disease due to rapidly growing mycobacteria (RGM) in patients with pre-existing chronic lung disease. Studies have described difficulties in correctly identifying closely related species, even when proper methodologies are adopted, and several different gene targets have been proposed. We describe two cases of RGM infection in a 29-year-old HIV-1 positive Congolese man and a 19-year-old HIV-1 positive Liberian woman, respectively, both with bronchiectasis due to previous Mycobacterium tuberculosis (MTB) infection. Mycobacterium porcinum and Mycobacterium bolletii were identified in bronchoalveolar lavage fluid and sputum, respect…

MOLECULAR CHARACTERIZATION OF PATIENTS WITH AND WITHOUT CORONARY ARTERY DISEASE WITH "EXTREME LDL-C PHENOTYPES"

Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study

Chronic obstructive pulmonary disease (COPD) increases the risk of mortality in non-valvular atrial fibrillation (NVAF) patients. Data on the relationship of COPD to major cardiovascular events (MACE) in AF have not been defined. The aim of the study is to assess the predictive value of COPD on incident MACE in NVAF patients over a 3-year follow-up. In the Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) cohort, we evaluate the impact of COPD on the following clinical endpoints: MACE (including vascular death, fatal/non-fatal MI and stroke/TIA), cardiovascular (CV) death and all-cause mortality. Among 2027 NVAF patients, pati…

Search for Supersymmetric Particles in e+e- Collisions at sqrt(s) up to 202GeV and Mass Limit for the Lightest Neutralino

Searches for pair production of squarks, sleptons, charginos, and neutralinos are performed with the data collected by the ALEPH detector at LEP at centre-of-mass energies from 188.6 to 201.6 GeV. No evidence for any such signals is observed in a total integrated luminosity of about 410pb-1. The negative results of the searches are translated into exclusion domains in the space of the relevant MSSM parameters, which improve significantly on the constraints set previously. Under the assumptions of gaugino and sfermion mass unification, these results allow a 95% C.L. lower limit of 37GeV/c2 to be set on the mass of the lightest neutralino for any tan beta and sfermion mass. Additional constra…

Studies of QCD at $e^{+}e^{-}$ centre-of-mass energies between 91 and 209 GeV

The hadronic final states observed with the ALEPH detector at LEP in e(+)e(-) annihilation are analysed using 730 pb(-1) of data collected between 91 and 209 GeV in the framework of QCD. In particular event-shape variables and inclusive charged particle spectra are measured. The energy evolution of quantities derived from these measurements is compared to analytic QCD predictions. The mean charged particle multiplicity, the charged particle momentum spectrum and its peak position are compared to predictions of the modified-leading-logarithmic approximation. The strong coupling constant alpha(s) is determined from a fit of the QCD prediction to distributions of six event-shape variables at e…

VIRULENCE FACTORS AND ANTIMICROBIAL RESISTANCE OF ESCHERICHIA COLI ST131 IN COMMUNITY-ONSET HEALTHCARE-ASSOCIATED INFECTIONS IN SICILY, ITALY

Escherichia coli ST131 is an emerging resistant agent recently called “superbug” in England. This strain is responsible of community-acquired urinary tract infections and nowadays showing increasing resistance to antibiotics like fluoroquinolones and cephalosporins. Survey of virulent bacterial clone is relevant to control its spreading in community. We aim to assess the circulation of resistant clones Escherichia coli ST131 outside of the hospital to prompt control of outbreak in our geographical area. We selected 105 E. coli resistant isolates from community-acquired urinary infections and performed a multiplex PCR to evaluate if they belonged to the ST131 type. We investigated their set …

Whooping cough, twenty years from acellular vaccines introduction

Clinical pertussis resulting from infection with B. pertussis is a significant medical and public health problem, despite the huge success of vaccination that has greatly reduced its incidence. The whole cell vaccine had an undeniable success over the last 50 years, but its acceptance was strongly inhibited by fear, only partially justified, of severe side effects, but also, in the Western world, by the difficulty to enter in combination with other vaccines: today multi-vaccine formulations are essential to maintain a high vaccination coverage. The advent of acellular vaccines was greeted with enthusiasm by the public health world: in the Nineties, several controlled vaccine trials were car…

Lipoprotein(a) and aortic valve stenosis: A casual or causal association?

Abstract Aims This review aims to provide an update of available methods for imaging calcification activity and potential therapeutic options. Data Synthesis: Aortic valve calcification represents the most common heart valve condition requiring treatment among adults in Western societies. No medical therapies are proven to be effective in treating symptoms or reducing disease progression. Therefore, surgical or transcatheter aortic valve replacement remains the only available treatment option. Elevated circulating concentrations of lipoprotein(a) is strongly associated with degenerative aortic stenosis. This relationship was first observed in prospective observational studies, and the causa…

Genotyping of Legionella pneumophila serogroup 1 strains isolated in Northern Sicily, Italy.

During a three-year period, from April 2002 to May 2005, one hundred-forty-seven samples, taken from technical systems of water distribution at point of use, were repeatedly collected at six different sites in Northern Sicily and assayed for the presence of Legionella pneumophila serogroup 1 and serogroups 2 to 14. At the first samplings, the water distribution systems of all the sites were heavily contaminated, and disinfection treatments by the superheat and flush method were therefore performed. Treatments were always successful against L. pneumophila sg.1, but only in a few cases against all other serogroups. Eighty-six strains of L. pneumophila sg. 1, isolated from 26 of these samples,…

Randomized Comparative Trial with Ceftizoxime and Cefotaxime in Urinary Tract Infections

Ceftizoxime, a new, semisynthetic, beta-lactamase-resistant cephalosporin, is not metabolized in man and is excreted almost entirely as the original active compound in the urine. The efficacy and safety of ceftizoxime were assessed in 80 patients with acute and chronic urinary infections, with and without associated pathological conditions, in comparison with cefotaxime. Two dosage schedules, 1 g or 0.5 g every 12 h, i.v. or i.m. for 10 days, were adopted according to the severity of each case and to separate randomization tables for each schedule; causal agents were all sensitive to both drugs in vitro. The overall results were excellent. Safety was excellent in almost all cases. In this t…

Collider aspects of flavour physics at high Q

This chapter of the 'Flavor in the era of LHC' workshop report discusses flavor-related issues in the production and decays of heavy states at the LHC at high momentum transfer Q, both from the experimental and the theoretical perspective. We review top quark physics, and discuss the flavor aspects of several extensions of the standard model, such as supersymmetry, little Higgs models or models with extra dimensions. This includes discovery aspects, as well as the measurement of several properties of these heavy states. We also present publicly available computational tools related to this topic. © Springer-Verlag / Società Italiana di Fisica 2008.

Final results of the searches for neutral Higgs bosons in e+e- collisions at sqrt(s) up to 209GeV

The final results of the ALEPH search for the Standard Model Higgs boson at LEP, with data collected in the year 2000 at centre-of-mass energies up to 209 GeV, are presented. The changes with respect to the preceding publication are described and a complete study of systematic effects is reported. The findings of this final analysis confirm the preliminary results published in November 2000 shortly after the closing down of the LEP collider: a significant excess of events is observed, consistent with the production of a $115 \Gcs$ Standard Model Higgs boson. The final results of the searches for the neutral Higgs bosons of the MSSM are also reported, in terms of limits on $\mh$, $\mA$ and $…

Deuteron and anti-deuteron production in e+e− collisions at the Z resonance

Deuteron and anti-deuteron production in Z decays has been observed in the ALEPH experiment at LEP. The production rate of anti-deuterons is measured to be 5.9+-1.8+-0.5 10^-6 per hadronic Z decay in the anti-deuteron momentum range 0.62 to 1.03 GeV/c. The coalescence parameter B_2, which characterizes the likelihood of anti-deuteron production, is measured to be 0.0033+-0.0013 GeV^2 in Z dedays. These measurements indicate that the production of anti-deuterons is suppressed in e+e- collisions compared to pp and photoproduction collisions.

Heterogenous forms of dyslipidemiain women with polycystic ovary syndrome

Forms of dyslipidemia are very common in individuals affected by polycystic ovary syndrome (PCOS), but in addition to plasmatic lipids, it is necessary to evaluate the alterations in the atherogenic lipoproteins (Lp) and apolipoproteins (apo). In our study we measured the concentrations of apoB, Lp(a) and low density lipoproteins (LDL) in 42 patients with PCOS (age: 28 +/- 7 years, body mass index: 27 +/- 5 kg/m-) and 37 healthy women (of the same age and body mass index). Methods: values of Lp(a) >30 mg/dl were considered high, whereas for apoB, values >100 g/l were considered high. Results: the patients with PCOS showed an increase in triglycerides (p=0.0011) and low levels of high densit…

Bose-Einstein correlations in W-pair decays with an event-mixing technique

Bose-Einstein correlations in W-pair decays are studied using data collected by the ALEPH detector at LEP at e(+)e(-) centre-of-mass energies from 183 to 209 GeV. The analysis is based on the comparison of WW --> q (q) over barq (q) over bar events to "mixed" events constructed with the hadronic part of WW --> q (q) over bar lv events. The data are in agreement with the hypothesis that Bose-Einstein correlations are present only for pions from the same W decay. The JETSET model with Bose-Einstein correlations between pions from different W bosons is disfavoured. (C) 2004 Elsevier B.V. All rights reserved.

A NEW CASE OF LOUSE-BORNE RELAPSING FEVER IN SICILY: CASE REPORT AND MINI REVIEW

Body lice transport B. recurrentis from man to man and humans are the only host. The presence of lice in Italy and an increasing number of cases in migrants can contribute to the onset of autochthonous cases. In this paper, we report a new case of Louse-borne Relapsing Fever (LBRF) diagnosed among migrants in Sicily exactly one year after the first case was recorded. We reviewed all cases reported in Europe from February 2016 until now. Our study identified two new cases of LBRF in migrants arrived in Europe: one who came from Somalia and one from Mali. Here we report data on a new case in Sicily. The number of migrants and refugees to transit in Sicily has increased, and this has led to th…

Search for Higgs bosons decaying to WW in e(+)e(-) stope collisions at LEP

A search for Higgs bosons produced in association with a fermion pair, and decaying to WW, is performed with the data collected by the ALEPH detector at centre-of-mass energies ranging from 191 to 209 GeV. The data correspond to an integrated luminosity of 453.2 pb^-1. Thirteen exclusive selections are developed according to the different final state topologies. No statistically significant evidence for a Higgs boson decaying into a WW pair has been found. An upper limit is derived, as a function of the Higgs boson mass, on the product of the e+e- -&gt; Hff cross section and the H -&gt; WW branching ratio. The data on the search for H -&gt; WW are combined with previously published ALEPH re…

Prevalence Of Statin Intolerance In A Cohort Of Outpatients In A Lipid Clinic

Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real‐life setting: the PROSISA Study

Aim: Statin-associated muscle symptoms (SAMS) are a major determinant of poor treatment adherence and/or discontinuation, but a definitive diagnosis of SAMS is challenging. The PROSISA study was an observational retrospective study aimed to assess the prevalence of reported SAMS in a cohort of dyslipidaemic patients. Methods: Demographic/anamnestic data, biochemical values and occurrence of SAMS were collected by 23 Italian Lipid Clinics. Adjusted logistic regression was performed to estimate odds ratio (OR) and 95% confidence intervals for association between probability of reporting SAMS and several factors. Results: Analyses were carried out on 16 717 statin-treated patients (mean ± SD, …

Monocyte to lymphocyte blood ratio in tuberculosis and HIV patients: Comparative analysis, preliminary data

Recent data confirmed the hypothesis suggested by historical studies that the ratio of peripheral blood monocytes to lymphocytes (M/L) is associated with the risk of tuberculosis (TB) disease. We retrospectively analyzed the electronic health records of tuberculosis and HIV-positive patients who had followed day-care programs at the AIDS Center of the University of Palermo, Italy. 261 patients were recruited and divided into 6 groups as follows: healthy control group (HCG: 47 pts), latent HIV negative infected TB group (LIG, 43 pts), active HIV negative tuberculosis (TAG: 61 pts), treated tuberculosis HIV negative (TTG: 44 pts), HIV drug-naive patients tested TST and QFT-IT-negative with ne…

Production of Ds** mesons in hadronic Z decays

The production rates of the orbitally excited Ds** mesons, Ds1 and Ds2*, are measured with the 4.1 million hadronic Z decays recorded by the ALEPH detector during 1991--1995. The Ds** mesons are reconstructed in the decay modes Ds1+ -&gt; D*+ K0, Ds1+ -&gt; D*0 K+ and Ds2*+ -&gt; D0 K+. The production rate of the Ds1 is measured to be n(Z-&gt;Ds1+-)=(0.52+-0.09+-0.06)%, under the assumption that the two considered decay modes of the Ds1 saturate the branching ratio. The production rate of the Ds2* is determined to be n(Z-&gt;Ds2*+-)=(0.83+-0.29+0.07-0.13)%, assuming that the branching fraction of the decay Ds2*+ -&gt; D0 K+ is 45%. The production rates in Z-&gt;cc and Z-&gt;bbar decays are …

Search for neutral MSSM Higgs bosons at LEP

The four LEP collaborations, ALEPH, DELPHI, L3 and OPAL, have searched for the neutral Higgs bosons which are predicted by the Minimal Supersymmetric Standard Model (MSSM). The data of the four collaborations are statistically combined and examined for their consistency with the background hypothesis and with a possible Higgs boson signal. The combined LEP data show no significant excess of events which would indicate the production of Higgs bosons. The search results are used to set upper bounds on the cross-sections of various Higgs-like event topologies. The results are interpreted within the MSSM in a number of "benchmark" models, including CP-conserving and CP-violating scenarios. Thes…

Leptonic decays of the D-s meson

The purely leptonic decays Ds -&gt; tau nu and Ds -&gt; mu nu are studied in a sample of four million hadronic Z decays collected with the ALEPH detector at the LEP e+e- collider from 1991 to 1995. The branching fractions are extracted from a combination of two analyses, one optimized to select Ds -&gt; tau nu decays with tau -&gt; e nu nubar or mu nu nubar, and the other optimized for Ds-&gt; mu nu decays. The results are used to evaluate the Ds decay constant, within the Standard Model: fDs = [285 +- 19(stat) +- 40 (syst)] MeV

Sherris - Microbiologia Medica

Il testo di Sherris “Medical Microbiology”, giunto oggi alla sua sesta edizione, continua a rappresentare, a livello internazionale, un testo cardine per lo studio della Microbiologiamedica sia nel Corso di Medicina e Chirurgia sia nell’ambito della formazionespecialistica. La prima edizione di questo testo venne pubblicata nel 1976 da John C. Sherris, Professore Emerito di Microbiologia, noto per gli studi sulle resistenze batteriche agli antibioticied il rapido evolversi delle Scienze Mediche ed in particolare della Microbiologia ha resonecessari numerosi aggiornamenti che hanno portato alla attuale sesta edizione. Abbiamo partecipato con entusiasmo alla prima edizione italiana e con altr…