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RESEARCH PRODUCT
Assessment of humoral and cell-mediated immunity against Bordetella pertussis in adolescent, adult, and senior subjects in Italy
Giovanni GabuttiM. BergaminiP. BonanniGuido SignorinoD. FenoglioA. GiammancoL. SindoniC. ZottiV. BoddiF. BamfiR. SeveriniA. BechiniS. BoccaliniP. CrovariS. DitommasoM. GentileG. LanciP. DurandoL. SticchiA. RenzoniP. FulianoG. TripodiA. CavallaroG. PesaventoT. Silei SecchiniB. InnocentiR. SqueriV. La FauciS. CalimeriD. Lo GiudiceA. De DonnoM. QuattrocchiF. SanapoG. C. PasanisiS. TaorminaC. BonuraC. Calã A. Ferrerasubject
MaleSettore MED/07 - Microbiologia E Microbiologia ClinicaCellular immunityBordetella pertussisEpidemiologyWhooping CoughBordetella pertussisSeroepidemiologic StudiesEpidemiology80 and overLymphocytesAged 80 and overeducation.field_of_studybiologyadultBacterialMiddle AgedOriginal PapersAntibodies BacterialseniorInfectious DiseasesB. pertussis Humoral and cell-mediated immunity ELISAItalyFemaleAntibodyAdultmedicine.medical_specialtyBordetella pertussiAdolescent; Adult; Aged; Aged 80 and over; Antibodies Bacterial; Antitoxins; Bordetella pertussis; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G; Italy; Lymphocytes; Male; Middle Aged; Seroepidemiologic Studies; Whooping Cough; Epidemiology; Infectious DiseasesAdolescentPopulationEnzyme-Linked Immunosorbent AssayAntibodiesNOImmunitymedicineHumanseducationimmunità cellulo mediataAgedbusiness.industrybiology.organism_classificationadolescentImmunoglobulin GHumoral immunityImmunologyEtiologybiology.proteinimmunità umoraleAntitoxinsbusinessdescription
SUMMARYHumoral and cell-mediated immunity (CMI) againstB. pertussiswas assessed in a sample of adolescent, adult and senior subjects distributed in five different geographical areas in Italy. Most (99·1%) subjects had IgG anti-pertussis toxin (PT) antibodies exceeding the minimum detection level [⩾2 ELISA units (EU)/ml]. There were no significant differences between the genders; 6·2% samples recorded titres ⩾100 EU/ml. CMI was positive [stimulation index (SI) ⩾5] against PT in 39·0% of all samples. This study suggests thatB. pertussiscontinues to circulate in age groups that have been previously considered to be uninvolved in the circulation of this pathogen and that adolescent and adult pertussis boosters may be of value in these populations. Nevertheless, over the last 10 years, large increases in vaccination coverage rates have contributed to reduce the spread of the aetiological agent, especially in the immunized population.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-01-16 |