0000000000538379

AUTHOR

R. Severini

showing 2 related works from this author

Assessment of humoral and cell-mediated immunity against Bordetella pertussis in adolescent, adult, and senior subjects in Italy

2008

SUMMARYHumoral and cell-mediated immunity (CMI) againstB. pertussiswas assessed in a sample of adolescent, adult and senior subjects distributed in five different geographical areas in Italy. Most (99·1%) subjects had IgG anti-pertussis toxin (PT) antibodies exceeding the minimum detection level [⩾2 ELISA units (EU)/ml]. There were no significant differences between the genders; 6·2% samples recorded titres ⩾100 EU/ml. CMI was positive [stimulation index (SI) ⩾5] against PT in 39·0% of all samples. This study suggests thatB. pertussiscontinues to circulate in age groups that have been previously considered to be uninvolved in the circulation of this pathogen and that adolescent and adult pe…

MaleSettore MED/07 - Microbiologia E Microbiologia ClinicaCellular immunityBordetella pertussisEpidemiologyWhooping CoughBordetella pertussisSeroepidemiologic StudiesEpidemiology80 and overLymphocytesAged 80 and overeducation.field_of_studybiologyadultBacterialMiddle AgedOriginal PapersAntibodies BacterialseniorInfectious DiseasesB. pertussis Humoral and cell-mediated immunity ELISAItalyFemaleAntibodyAdultmedicine.medical_specialtyBordetella pertussiAdolescent; Adult; Aged; Aged 80 and over; Antibodies Bacterial; Antitoxins; Bordetella pertussis; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G; Italy; Lymphocytes; Male; Middle Aged; Seroepidemiologic Studies; Whooping Cough; Epidemiology; Infectious DiseasesAdolescentPopulationEnzyme-Linked Immunosorbent AssayAntibodiesNOImmunitymedicineHumanseducationimmunità cellulo mediataAgedbusiness.industrybiology.organism_classificationadolescentImmunoglobulin GHumoral immunityImmunologyEtiologybiology.proteinimmunità umoraleAntitoxinsbusiness
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Prevalence of diphtheria toxin antibodies in human sera from a cross-section of the Italian population.

1999

Abstract A polycentric study was carried out between 1993 and 1995 in order to evaluate diphtheria immunity on a representative sample of population from different areas of Italy. To determine diphtheria antitoxin, sera from 5187 apparently healthy subjects, divided according to sex and age groups, were titrated using an ELISA indirect method. A basic protective titre of diphtheria antitoxin (>0.01 IU ml −1 ) was found in 4080 (78.6%) subjects. No statistically significant differences between males and females were observed. Our findings show that the proportion of susceptibles increases with age and a high proportion of adults no longer has diphtheria antitoxin at protective levels since t…

MaleCross-sectional studySerologySeroepidemiologic StudiesPrevalenceCluster AnalysisDiphtheria ToxinChildAged 80 and overeducation.field_of_studybiologyImmunoenzyme techniquesDiphtheriaMiddle AgedAntibodies BacterialInfectious DiseasesItalyChild PreschoolCross-sectional studiesMolecular MedicineFemaleAdults; Cross-sectional studies; Diphtheria; Diphtheria antitoxin; Immunoenzyme techniques; ItalyAntibodyAdultDiphtheria antitoxinAdolescentPopulationcomplex mixturesNOAge DistributionImmunitymedicineHumansAdultsSex DistributioneducationAgedDiphtheria toxinGeneral VeterinaryGeneral Immunology and Microbiologybusiness.industryDiphtheriaPublic Health Environmental and Occupational HealthInfantmedicine.diseaseDiphtheria; Diphtheria antitoxin; Cross-sectional studies; Immunoenzyme techniques; Adults; ItalyImmunologyHumoral immunitybiology.proteinbusiness
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